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Gut. 1991 January; 32(1): 80–84.
PMCID: PMC1379219

Steroid hormone abnormalities in women with severe idiopathic constipation.

Abstract

Patients with severe idiopathic constipation are almost exclusively women of reproductive age. To investigate the possibility of a sex hormone abnormality in this condition, we have compared a range of sex hormones during the follicular and luteal phases of the menstrual cycle in 23 healthy women (mean age 33 years) with those in 26 patients with severe idiopathic constipation (mean age 32 years, spontaneous bowel frequency less than one per week). In the patients there was a reduction in the follicular phase of progesterone (4.5 v 4 nmol/l, p = 0.006, median value, controls v patients), 17 hydroxyprogesterone (9.7 v 5.8 nmol/l, p = 0.01), cortisol (387 v 245 nmol/l, p = 0.008), testosterone (2.3 v 1.8 nmol/l, p less than 0.001), androstenedione (10.3 v 8.4 nmol/l, p = 0.02), and dehydroepiandrosterone sulphate (5.1 v 3.0 mumol/l, p = 0.03). In the luteal phase there was a reduction of oestradiol (483 v 350 pmol/l, p = 0.015), cortisol (322 v 242 nmol/l, p = 0.047), and testosterone (2.4 v 1.7 nmol/l, p = 0.003). The concentrations of sex hormone binding globulin, prolactin, luteinising hormone, and follicle stimulating hormone were not significantly different in either phase of the cycle. Women with severe idiopathic constipation have a consistent reduction in steroid hormones.

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Selected References

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  • Preston DM, Lennard-Jones JE. Severe chronic constipation of young women: 'idiopathic slow transit constipation'. Gut. 1986 Jan;27(1):41–48. [PMC free article] [PubMed]
  • Read NW, Timms JM, Barfield LJ, Donnelly TC, Bannister JJ. Impairment of defecation in young women with severe constipation. Gastroenterology. 1986 Jan;90(1):53–60. [PubMed]
  • Shouler P, Keighley MR. Changes in colorectal function in severe idiopathic chronic constipation. Gastroenterology. 1986 Feb;90(2):414–420. [PubMed]
  • Reynolds JC, Ouyang A, Lee CA, Baker L, Sunshine AG, Cohen S. Chronic severe constipation. Prospective motility studies in 25 consecutive patients. Gastroenterology. 1987 Feb;92(2):414–420. [PubMed]
  • Kamm MA, McLean A, Farthing MJ, Lennard-Jones JE. Ultrasonography shows no abnormality of pelvic structures in women with severe idiopathic constipation. Gut. 1989 Sep;30(9):1241–1243. [PMC free article] [PubMed]
  • Watier A, Devroede G, Duranceau A, Abdel-Rahman M, Duguay C, Forand MD, Tétreault L, Arhan P, Lamarche J, Elhilali M. Constipation with colonic inertia. A manifestation of systemic disease? Dig Dis Sci. 1983 Nov;28(11):1025–1033. [PubMed]
  • Hinton JM, Lennard-Jones JE, Young AC. A ne method for studying gut transit times using radioopaque markers. Gut. 1969 Oct;10(10):842–847. [PMC free article] [PubMed]
  • Wathen NC, Perry L, Lilford RJ, Chard T. Interpretation of single progesterone measurement in diagnosis of anovulation and defective luteal phase: observations on analysis of the normal range. Br Med J (Clin Res Ed) 1984 Jan 7;288(6410):7–9. [PMC free article] [PubMed]
  • Cunnah D, Jessop DS, Besser GM, Rees LH. Measurement of circulating corticotrophin-releasing factor in man. J Endocrinol. 1987 Apr;113(1):123–131. [PubMed]
  • Wathen NC, Perry LA, Rubenstein E, Chard T. A relationship between sex hormone binding globulin and dehydroepiandrosterone sulfate in normally menstruating females. Gynecol Endocrinol. 1987 Mar;1(1):47–50. [PubMed]
  • el-Gamal BA, Landon J, Abuknesha RA, Gallacher G, Perry LA. The production and characterisation of antisera to 17-hydroxyprogesterone. J Steroid Biochem. 1987 Mar;26(3):375–382. [PubMed]
  • Holly JM, Smith CP, Dunger DB, Howell RJ, Chard T, Perry LA, Savage MO, Cianfarani S, Rees LH, Wass JA. Relationship between the pubertal fall in sex hormone binding globulin and insulin-like growth factor binding protein-I. A synchronized approach to pubertal development? Clin Endocrinol (Oxf) 1989 Sep;31(3):277–284. [PubMed]
  • Fattah DI, Chard T. Simplified method for measuring sex-hormone binding globulin. Clin Chem. 1981 Jul;27(7):1277–1279. [PubMed]
  • Adlercreutz H, Martin F, Järvenpä P, Fotsis T. Steroid absorption and enterohepatic recycling. Contraception. 1979 Sep;20(3):201–223. [PubMed]
  • Bannister JJ, Timms JM, Barfield LJ, Donnelly TC, Read NW. Physiological studies in young women with chronic constipation. Int J Colorectal Dis. 1986 Jul;1(3):175–182. [PubMed]
  • Stephen AM, Wiggins HS, Cummings JH. Effect of changing transit time on colonic microbial metabolism in man. Gut. 1987 May;28(5):601–609. [PMC free article] [PubMed]
  • Trolle D, Pedersen SN, Gaede P. Estriol concentrations in urine and serum in patients with various intestinal diseases. Acta Obstet Gynecol Scand. 1977;56(4):347–349. [PubMed]
  • Jänne OA, Laatikainen TJ, Vihko RK. Effect of reduction of the intestinal microflora on the excretion of neutral steroids in human faeces and urine. Eur J Biochem. 1971 May 11;20(1):120–123. [PubMed]
  • Hartiala K. Metabolism of hormones, drugs and other substances by the gut. Physiol Rev. 1973 Apr;53(2):496–534. [PubMed]
  • Farthing MJ, Vinson GP, Edwards CR, Dawson AM. Testosterone metabolism by the rat gastrointestinal tract, in vitro and in vivo. Gut. 1982 Mar;23(3):226–234. [PMC free article] [PubMed]
  • Van Thiel DH, Gavaler JS, Joshi SN, Sara RK, Stremple J. Heartburn of pregnancy. Gastroenterology. 1977 Apr;72(4 Pt 1):666–668. [PubMed]
  • Davison JS, Davison MC, Hay DM. Gastric emptying time in late pregnancy and labour. J Obstet Gynaecol Br Commonw. 1970 Jan;77(1):37–41. [PubMed]
  • Braverman DZ, Johnson ML, Kern F., Jr Effects of pregnancy and contraceptive steroids on gallbladder function. N Engl J Med. 1980 Feb 14;302(7):362–364. [PubMed]
  • Wald A, Van Thiel DH, Hoechstetter L, Gavaler JS, Egler KM, Verm R, Scott L, Lester R. Gastrointestinal transit: the effect of the menstrual cycle. Gastroenterology. 1981 Jun;80(6):1497–1500. [PubMed]
  • Wald A, Van Thiel DH, Hoechstetter L, Gavaler JS, Egler KM, Verm R, Scott L, Lester R. Effect of pregnancy on gastrointestinal transit. Dig Dis Sci. 1982 Nov;27(11):1015–1018. [PubMed]
  • Gill RC, Bowes KL, Kingma YJ. Effect of progesterone on canine colonic smooth muscle. Gastroenterology. 1985 Jun;88(6):1941–1947. [PubMed]
  • Bruce LA, Behsudi FM. Progesterone effects on three regional gastrointestinal tissues. Life Sci. 1979 Aug 27;25(9):729–734. [PubMed]
  • Turnbull GK, Thompson DG, Day S, Martin J, Walker E, Lennard-Jones JE. Relationships between symptoms, menstrual cycle and orocaecal transit in normal and constipated women. Gut. 1989 Jan;30(1):30–34. [PMC free article] [PubMed]
  • Kamm MA, Farthing MJ, Lennard-Jones JE. Bowel function and transit rate during the menstrual cycle. Gut. 1989 May;30(5):605–608. [PMC free article] [PubMed]
  • Schrøder HD. Anatomical and pathoanatomical studies on the spinal efferent systems innervating pelvic structures. 1. Organization of spinal nuclei in animals. 2. The nucleus X-pelvic motor system in man. J Auton Nerv Syst. 1985 Sep;14(1):23–48. [PubMed]
  • Breedlove SM, Arnold AP. Hormone accumulation in a sexually dimorphic motor nucleus of the rat spinal cord. Science. 1980 Oct 31;210(4469):564–566. [PubMed]

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