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Gut. 1993; 34(2 Suppl): S130–S132.
PMCID: PMC1374038

Recombinant human interferon alfa-2b treatment for acute non-A, non-B hepatitis.


To assess the safety and possible efficacy of recombinant human interferon alfa-2b in preventing the development of chronic hepatitis, 24 adults (eight men, 16 women) with acute non-A, non-B (NANB) hepatitis were recruited to a pilot study. Half of the cases were parenterally transmitted and half were community acquired. Twelve patients received 3 million units (MU) interferon three times weekly subcutaneously for six weeks and the remaining 12 patients received no treatment. Anti-hepatitis C virus (HCV) was detected in 14 (58.3%) of the 24 patients. The alanine aminotransferase activity returned to normal in nine of 12 interferon alfa-2b treated patients and six of 12 controls by week 52. Interferon alfa-2b was well tolerated, even in jaundiced patients, who only complained of mild flu like syndrome during the first week of treatment. These data are consistent with the hypothesis that interferon alfa-2b may help prevent progression to chronic hepatitis (interferon alfa-2b 25% v controls 50%), particularly in anti-HCV negative cases (interferon alfa-2b none of six v controls two of four). A randomised, double blind placebo-controlled trial is required, however, to substantiate these results further.

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Selected References

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  • Berman M, Alter HJ, Ishak KG, Purcell RH, Jones EA. The chronic sequelae of non-A, non-B hepatitis. Ann Intern Med. 1979 Jul;91(1):1–6. [PubMed]
  • Sampliner RE, Woronow DI, Alter MJ, Smallwood LA, Tabor E, Deinhardt F, Roggendorf M, Gerety RJ. Community-acquired non-A, non-B hepatitis: clinical characteristics and chronicity. J Med Virol. 1984;13(2):125–130. [PubMed]
  • Nagata A, Kiyosawa K, Koike Y, Miura M, Gibo Y, Sodeyama T, Wada S, Akahane Y, Furuta S. Epidemiology of sporadic acute non-A, non-B hepatitis in Japan: a comparison with hepatitis A and B. Am J Gastroenterol. 1985 Apr;80(4):298–302. [PubMed]
  • Tassopoulos NC, Alikiotis M, Limotirakis F, Nicolakakis P, Mela H, Paralogou-Ioannides M. Acute sporadic non-A, non-B hepatitis in Greece. J Med Virol. 1988 Sep;26(1):71–77. [PubMed]
  • Tassopoulos NC, Hatzakis A, Delladetsima I, Koutelou MG, Todoulos A, Miriagou V. Role of hepatitis C virus in acute non-A, non-B hepatitis in Greece: a 5-year prospective study. Gastroenterology. 1992 Mar;102(3):969–972. [PubMed]
  • Di Bisceglie AM, Martin P, Kassianides C, Lisker-Melman M, Murray L, Waggoner J, Goodman Z, Banks SM, Hoofnagle JH. Recombinant interferon alfa therapy for chronic hepatitis C. A randomized, double-blind, placebo-controlled trial. N Engl J Med. 1989 Nov 30;321(22):1506–1510. [PubMed]
  • Davis GL, Balart LA, Schiff ER, Lindsay K, Bodenheimer HC, Jr, Perrillo RP, Carey W, Jacobson IM, Payne J, Dienstag JL, et al. Treatment of chronic hepatitis C with recombinant interferon alfa. A multicenter randomized, controlled trial. Hepatitis Interventional Therapy Group. N Engl J Med. 1989 Nov 30;321(22):1501–1506. [PubMed]
  • Van der Poel CL, Cuypers HT, Reesink HW, Weiner AJ, Quan S, Di Nello R, Van Boven JJ, Winkel I, Mulder-Folkerts D, Exel-Oehlers PJ, et al. Confirmation of hepatitis C virus infection by new four-antigen recombinant immunoblot assay. Lancet. 1991 Feb 9;337(8737):317–319. [PubMed]
  • Acute and chronic hepatitis revisited. Review by an international group. Lancet. 1977 Oct 29;2(8044):914–919. [PubMed]
  • Omata M, Yokosuka O, Takano S, Kato N, Hosoda K, Imazeki F, Tada M, Ito Y, Ohto M. Resolution of acute hepatitis C after therapy with natural beta interferon. Lancet. 1991 Oct 12;338(8772):914–915. [PubMed]

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