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Gut. 1993; 34(2 Suppl): S114–S118.
PMCID: PMC1374031

High dose interferon treatment in chronic hepatitis C.


One hundred and twenty six patients were enrolled in a study to assess the effect of different interferon alfa-2b treatment regimens on the rate of increase in alanine aminotransferase (ALT) activities after treatment. Results indicated that a high daily dosage of interferon (10 million units (MU)) given six times a week for two weeks followed by 12 weeks of thrice weekly dosing was more effective at producing sustained normal ALT values than either eight weeks of 10 MU interferon six times a week or four weeks of 10 MU six times a week followed by eight weeks of thrice weekly dosing. Multiple regression analysis of clinical parameters before treatment showed that the outcome was dependent upon treatment group (p < 0.001) and the initial hepatitis C virus (HCV)-RNA value (p < 0.05). Anti-HCV titre and liver histology had a considerable but not significant effect on the response to treatment. The most frequently observed side effect was flu like syndrome, which occurred in over 90% of patients. In addition, 21% of patients experienced some degree of hair loss. Treatment was stopped because of side effects in 11 of 126 (9%) patients, evenly distributed between the three groups.

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Selected References

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  • Hoofnagle JH, Mullen KD, Jones DB, Rustgi V, Di Bisceglie A, Peters M, Waggoner JG, Park Y, Jones EA. Treatment of chronic non-A,non-B hepatitis with recombinant human alpha interferon. A preliminary report. N Engl J Med. 1986 Dec 18;315(25):1575–1578. [PubMed]
  • Tinè F, Magrin S, Craxì A, Pagliaro L. Interferon for non-A, non-B chronic hepatitis. A meta-analysis of randomised clinical trials. J Hepatol. 1991 Sep;13(2):192–199. [PubMed]
  • von Wussow P, Freund M, Block B, Diedrich H, Poliwoda H, Deicher H. Clinical significance of anti-IFN-alpha antibody titres during interferon therapy. Lancet. 1987 Sep 12;2(8559):635–636. [PubMed]
  • Burman P, Tötterman TH, Oberg K, Karlsson FA. Thyroid autoimmunity in patients on long term therapy with leukocyte-derived interferon. J Clin Endocrinol Metab. 1986 Nov;63(5):1086–1090. [PubMed]
  • Silva MO, Reddy KR, Jeffers LJ, Hill M, Schiff ER. Interferon-induced chronic active hepatitis? Gastroenterology. 1991 Sep;101(3):840–842. [PubMed]
  • Kuo G, Choo QL, Alter HJ, Gitnick GL, Redeker AG, Purcell RH, Miyamura T, Dienstag JL, Alter MJ, Stevens CE, et al. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science. 1989 Apr 21;244(4902):362–364. [PubMed]
  • Van der Poel CL, Cuypers HT, Reesink HW, Weiner AJ, Quan S, Di Nello R, Van Boven JJ, Winkel I, Mulder-Folkerts D, Exel-Oehlers PJ, et al. Confirmation of hepatitis C virus infection by new four-antigen recombinant immunoblot assay. Lancet. 1991 Feb 9;337(8737):317–319. [PubMed]
  • Okamoto H, Okada S, Sugiyama Y, Tanaka T, Sugai Y, Akahane Y, Machida A, Mishiro S, Yoshizawa H, Miyakawa Y, et al. Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 5'-noncoding region. Jpn J Exp Med. 1990 Aug;60(4):215–222. [PubMed]
  • Di Bisceglie AM, Martin P, Kassianides C, Lisker-Melman M, Murray L, Waggoner J, Goodman Z, Banks SM, Hoofnagle JH. Recombinant interferon alfa therapy for chronic hepatitis C. A randomized, double-blind, placebo-controlled trial. N Engl J Med. 1989 Nov 30;321(22):1506–1510. [PubMed]
  • Marcellin P, Boyer N, Giostra E, Degott C, Courouce AM, Degos F, Coppere H, Cales P, Couzigou P, Benhamou JP. Recombinant human alpha-interferon in patients with chronic non-A, non-B hepatitis: a multicenter randomized controlled trial from France. Hepatology. 1991 Mar;13(3):393–397. [PubMed]

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