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Gut. 1993; 34(2 Suppl): S97–S98.
PMCID: PMC1374022

Low dose alpha interferon treatment in chronic hepatitis B virus infection.


Fifty eight patients with chronic viral hepatitis B (HBV) were randomised in a prospectively controlled trial. Thirty patients were treated with 3 million units (MU) of interferon alfa-2b subcutaneously thrice weekly for four months. Twenty eight controls received no treatment. The follow up period after treatment was six months. Twenty eight treated patients and 27 controls completed the protocol. One woman in the treatment group showed a complete response, and eight other treated patients (32%) showed a partial response. Three patients in the control group (11%) lost hepatitis B e antigen and HBV-DNA spontaneously. This finding is statistically significant (p < 0.05). The elimination of HBV markers from the serum was associated with a return to normal of serum aminotransferase activities. Reactivation of hepatitis was not observed after seroconversion.

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Selected References

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  • Hoofnagle JH, Peters M, Mullen KD, Jones DB, Rustgi V, Di Bisceglie A, Hallahan C, Park Y, Meschievitz C, Jones EA. Randomized, controlled trial of recombinant human alpha-interferon in patients with chronic hepatitis B. Gastroenterology. 1988 Nov;95(5):1318–1325. [PubMed]
  • Carreño V, Porres JC, Mora I, Gutiez J, Quiroga JA, Ramón y Cajal S, Oliva H, Compernolle C, Bartolomé J. A controlled study of treatment with recombinant interferon alpha in chronic hepatitis B virus infection: induction and maintenance schedules. Antiviral Res. 1987 Oct;8(3):125–137. [PubMed]
  • Lok AS, Lai CL, Wu PC. Interferon therapy of chronic hepatitis B virus infection in Chinese. J Hepatol. 1986;3 (Suppl 2):S209–S215. [PubMed]
  • Müller R, Klein H, Vido I, Niehoff G, Lautz HU, Gebel M, Schmidt FW. Antiviral treatment in chronic hepatitis B. Data of 5 prospectively controlled randomized trials. J Hepatol. 1986;3 (Suppl 2):S217–S223. [PubMed]

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