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Logo of compmedJournal Web siteSee also archive of Canadian Journal of Comparative MedicineNow Published as Canadian Journal of Veterinary ResearchFormerly published as Canadian Journal of Comparative Medicine and Veterinary Science. 1940 to 1968.
 
Can J Comp Med. Oct 1982; 46(4): 430–433.
PMCID: PMC1320311
Attempts to produce granulomatous colitis in Boxer dogs with a mycoplasma.
P S Bowe, H J Van Kruiningen, and S Rosendal
Abstract
Four of six Boxer dogs with granulomatous colitis had mycoplasmas in the colon and three in the draining lymph node as well. One isolate identical with Mycoplasma strain HRC-689 was inoculated into the colon of five Boxer dogs at eight weeks of age; four controls were inoculated with medium. Animals were killed at two week intervals and examined. The mycoplasma strain produced changes of the colon characterized by lymphocytic infiltration of mucosa, lymphocytic submucosal perivasculitis, and enlargement of colonic lymphoid nodules but granulomatous colitis did not occur. The experimental dogs developed antibodies, and dogs from a kennel with a high prevalence of colitis cases had high antibody titers against strain HRC-689.
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