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Logo of compmedJournal Web siteSee also archive of Canadian Journal of Comparative MedicineNow Published as Canadian Journal of Veterinary ResearchFormerly published as Canadian Journal of Comparative Medicine and Veterinary Science. 1940 to 1968.
 
Can J Comp Med. Oct 1980; 44(4): 459–465.
PMCID: PMC1320106
Dietary induction of renal mineralization in dogs.
R E Schmidt, G B Hubbard, J L Booker, and C A Gleiser
Abstract
Ten dogs were fed diets high in phosphorus and low in calcium to induce secondary hyperparathyroidism, with ten dogs fed a standard diet as controls. At the end of the feeding period, all dogs were necropsied. Because of an apparent increase in mineral deposits in the kidneys of hyperparathyroid dogs, the amount and characteristics of these mineral deposits were compared. The dogs in the test groups had larger and more widely disseminated deposits. Five additional dogs were nephrectomized unilaterally, fed the test diet and euthanized at three-month intervals. In these dogs, the amount of renal mineral increased until six months after the start of the test diet, but dit not appreciably change between six and 15 months postdiet. When compared to controls, the test dog kidneys in this second experiment had a greater amount and wider distribution of renal mineralization and tubular dilatation.
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