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Logo of compmedJournal Web siteSee also archive of Canadian Journal of Comparative MedicineNow Published as Canadian Journal of Veterinary ResearchFormerly published as Canadian Journal of Comparative Medicine and Veterinary Science. 1940 to 1968.
Can J Comp Med. 1980 July; 44(3): 338–345.
PMCID: PMC1320083

Sulfamethazine residues in uncooked edible tissues of port following recommended oral administration and withdrawal.


Commercial feed rations containing sulfamethazine at the level of 110 ppm were fed for a period of 65 days to market pigs in a study simulating normal farm practices. The levels of sulfamethazine at the end of medication were in excess of 10 ppm in liver and kidney and up to 2.6 ppm in muscle tissues. Concentrations of sulfamethazine in tissues from pigs after withdrawal of medicated feed depleted to 0.1 ppm within nine days. The rate of depletion was similar for all tissues. It was observed that storage of tissue samples at freezer temperature (-20 degrees C) for 30 days further reduces sulfamethazine levels by 3 to 20% of their original value.

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Selected References

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  • Bevill RF, Sharma RM, Meachum SH, Wozniak SC, Bourne DW, Dittert LW. Disposition of sulfonamides in food-producing animals: concentrations of sulfamethazine and its metabolites in plasma, urine, and tissues of lambs following intravenous administration. Am J Vet Res. 1977 Jul;38(7):973–977. [PubMed]
  • Cieri UR. Detection of sulfonamides in animal feeds. J Assoc Off Anal Chem. 1976 Jan;59(1):56–59. [PubMed]
  • Gyllenhaal O, Ehrsson H. Determination of sulphonamides by electron-capture gas chromatography. Preparation and properties of perfluoroacyl and pentafluorobenzyl derivatives. J Chromatogr. 1975 Apr 16;107(2):327–333. [PubMed]
  • Lehmann RP. Implementation of the recommendations contained in the report to the Commissioner concerning the use of antibiotics in animal feed. J Anim Sci. 1972 Dec;35(6):1340–1341. [PubMed]
  • Mutha SC, Brown TL, Chamberlain B, Lee CE. Sulfamethazine residue in calf tissues. J Agric Food Chem. 1977 May-Jun;25(3):556–558. [PubMed]
  • Nose N, Kobayashi S, Hirose A, Watanabe A. Gas-liquid chromatographic determination of sulphonamides. J Chromatogr. 1976 Jul 21;123(1):167–173. [PubMed]
  • Phillips WF, Trafton JE. A screening method for sulfonamides extracted from animal tissues. J Assoc Off Anal Chem. 1975 Jan;58(1):44–47. [PubMed]

Articles from Canadian Journal of Comparative Medicine are provided here courtesy of Canadian Veterinary Medical Association