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Recent surveys have highlighted sources of stress for UK general practitioners (GPs). Interventions to reduce stress in general practice have been introduced at both an individual and an organizational level, but there is little published evidence of their effectiveness. This paper systematically reviews the literature and reports that the research evidence from stress management programmes employed with other workforces is equivocal. Results so far suggest that relaxation and cognitive behavioural skills are helpful and that group methods are both more cost-effective and more beneficial than individual counselling. It is important for scientific, practical, and financial reasons that stress management programmes be properly evaluated. This paper suggests possible avenues for future interventions to alleviate stress.