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J R Soc Med. 2003; 96(Suppl 43): 57–65.
PMCID: PMC1308789

Sequencing of the Pseudomonas aeruginosa and Burkholderia cepacia genomes and their applications in relation to cystic fibrosis.

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Selected References

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  • Govan JR, Deretic V. Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol Rev. 1996 Sep;60(3):539–574. [PMC free article] [PubMed]
  • Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, et al. Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959–964. [PubMed]
  • Jones Andrew M, Webb A Kevin, Govan John R W, Hart C Anthony, Walshaw Martin J. Pseudomonas aeruginosa cross-infection in cystic fibrosis. Lancet. 2002 Feb 9;359(9305):527–528. [PubMed]
  • Mahenthiralingam Eshwar, Baldwin Adam, Vandamme Peter. Burkholderia cepacia complex infection in patients with cystic fibrosis. J Med Microbiol. 2002 Jul;51(7):533–538. [PubMed]
  • Coenye T, Vandamme P, Govan JR, LiPuma JJ. Taxonomy and identification of the Burkholderia cepacia complex. J Clin Microbiol. 2001 Oct;39(10):3427–3436. [PMC free article] [PubMed]
  • Vandamme P, Holmes B, Vancanneyt M, Coenye T, Hoste B, Coopman R, Revets H, Lauwers S, Gillis M, Kersters K, et al. Occurrence of multiple genomovars of Burkholderia cepacia in cystic fibrosis patients and proposal of Burkholderia multivorans sp. nov. Int J Syst Bacteriol. 1997 Oct;47(4):1188–1200. [PubMed]
  • Mahenthiralingam E, Vandamme P, Campbell ME, Henry DA, Gravelle AM, Wong LT, Davidson AG, Wilcox PG, Nakielna B, Speert DP. Infection with Burkholderia cepacia complex genomovars in patients with cystic fibrosis: virulent transmissible strains of genomovar III can replace Burkholderia multivorans. Clin Infect Dis. 2001 Nov 1;33(9):1469–1475. [PubMed]
  • Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. 1995 Jul 28;269(5223):496–512. [PubMed]
  • Fraser CM, Eisen JA, Salzberg SL. Microbial genome sequencing. Nature. 2000 Aug 17;406(6797):799–803. [PubMed]
  • HOLLOWAY BW. Genetic recombination in Pseudomonas aeruginosa. J Gen Microbiol. 1955 Dec;13(3):572–581. [PubMed]
  • Bentley SD, Chater KF, Cerdeño-Tárraga A-M, Challis GL, Thomson NR, James KD, Harris DE, Quail MA, Kieser H, Harper D, et al. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature. 2002 May 9;417(6885):141–147. [PubMed]
  • Brinkman FS, Hancock RE, Stover CK. Sequencing solution: use volunteer annotators organized via Internet. Nature. 2000 Aug 31;406(6799):933–933. [PubMed]
  • Govan JR, Brown PH, Maddison J, Doherty CJ, Nelson JW, Dodd M, Greening AP, Webb AK. Evidence for transmission of Pseudomonas cepacia by social contact in cystic fibrosis. Lancet. 1993 Jul 3;342(8862):15–19. [PubMed]
  • Mahenthiralingam E, Coenye T, Chung JW, Speert DP, Govan JR, Taylor P, Vandamme P. Diagnostically and experimentally useful panel of strains from the Burkholderia cepacia complex. J Clin Microbiol. 2000 Feb;38(2):910–913. [PMC free article] [PubMed]
  • Martin DW, Mohr CD. Invasion and intracellular survival of Burkholderia cepacia. Infect Immun. 2000 Jan;68(1):24–29. [PMC free article] [PubMed]
  • Tomich Mladen, Herfst Christine A, Golden Joseph W, Mohr Christian D. Role of flagella in host cell invasion by Burkholderia cepacia. Infect Immun. 2002 Apr;70(4):1799–1806. [PMC free article] [PubMed]
  • Sokol PA, Darling P, Woods DE, Mahenthiralingam E, Kooi C. Role of ornibactin biosynthesis in the virulence of Burkholderia cepacia: characterization of pvdA, the gene encoding L-ornithine N(5)-oxygenase. Infect Immun. 1999 Sep;67(9):4443–4455. [PMC free article] [PubMed]
  • Lewenza S, Conway B, Greenberg EP, Sokol PA. Quorum sensing in Burkholderia cepacia: identification of the LuxRI homologs CepRI. J Bacteriol. 1999 Feb;181(3):748–756. [PMC free article] [PubMed]
  • Mohr CD, Tomich M, Herfst CA. Cellular aspects of Burkholderia cepacia infection. Microbes Infect. 2001 Apr;3(5):425–435. [PubMed]
  • Parke JL, Gurian-Sherman D. Diversity of the Burkholderia cepacia complex and implications for risk assessment of biological control strains. Annu Rev Phytopathol. 2001;39:225–258. [PubMed]
  • Lessie TG, Hendrickson W, Manning BD, Devereux R. Genomic complexity and plasticity of Burkholderia cepacia. FEMS Microbiol Lett. 1996 Nov 1;144(2-3):117–128. [PubMed]
  • Roy-Burman A, Savel RH, Racine S, Swanson BL, Revadigar NS, Fujimoto J, Sawa T, Frank DW, Wiener-Kronish JP. Type III protein secretion is associated with death in lower respiratory and systemic Pseudomonas aeruginosa infections. J Infect Dis. 2001 Jun 15;183(12):1767–1774. [PubMed]
  • Frank Dara W, Vallis Amy, Wiener-Kronish Jeanine P, Roy-Burman Arup, Spack Edward G, Mullaney Brian P, Megdoud Mehdi, Marks James D, Fritz Robert, Sawa Teiji. Generation and characterization of a protective monoclonal antibody to Pseudomonas aeruginosa PcrV. J Infect Dis. 2002 Jul 1;186(1):64–73. [PubMed]
  • Hensel M, Holden DW. Molecular genetic approaches for the study of virulence in both pathogenic bacteria and fungi. Microbiology. 1996 May;142(Pt 5):1049–1058. [PubMed]
  • McGall Glenn H, Christians Fred C. High-density genechip oligonucleotide probe arrays. Adv Biochem Eng Biotechnol. 2002;77:21–42. [PubMed]
  • Whiteley M, Bangera MG, Bumgarner RE, Parsek MR, Teitzel GM, Lory S, Greenberg EP. Gene expression in Pseudomonas aeruginosa biofilms. Nature. 2001 Oct 25;413(6858):860–864. [PubMed]
  • Liang X, Pham XQ, Olson MV, Lory S. Identification of a genomic island present in the majority of pathogenic isolates of Pseudomonas aeruginosa. J Bacteriol. 2001 Feb;183(3):843–853. [PMC free article] [PubMed]
  • Rosamond J, Allsop A. Harnessing the power of the genome in the search for new antibiotics. Science. 2000 Mar 17;287(5460):1973–1976. [PubMed]
  • Kline Toni, Andersen Niels H, Harwood Eric A, Bowman Jason, Malanda Andre, Endsley Stephanie, Erwin Alice L, Doyle Michael, Fong Susan, Harris Alex L, et al. Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC. J Med Chem. 2002 Jul 4;45(14):3112–3129. [PubMed]

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