PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of westjmedLink to Publisher's site
 
West J Med. 1985 March; 142(3): 345–347.
PMCID: PMC1306024

Indomethacin Therapy for Hypertrophic Pulmonary Osteoarthropathy in Patients With Bronchogenic Carcinoma

Abstract

Hypertrophic pulmonary osteoarthropathy (HPO) is a disabling complication of lung cancer often requiring thoracotomy with vagotomy for control of pain. This condition was confirmed by scintigraphy in six consecutive patients with biopsy-proved lung cancer. All had characteristic bone and joint pain unresponsive to a variety of analgesics. Treatment with indomethacin gave dramatic relief of pain within 72 hours in all six. Consideration should be given to instituting a controlled trial to establish the efficacy of indomethacin for the treatment of HPO.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (719K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • HOLLING HE, BRODEY RS. Pulmonary hypertrophic osteoarthropathy. JAMA. 1961 Dec 9;178:977–982. [PubMed]
  • Lemen RJ, Gates AJ, Mathé AA, Waring WW, Hyman AL, Kadowitz PD. Relationships among digital clubbing, disease severity, and serum prostaglandins F2alpha and E concentrations in cystic fibrosis patients. Am Rev Respir Dis. 1978 Apr;117(4):639–646. [PubMed]
  • Chambers TJ. The cellular basis of bone resorption. Clin Orthop Relat Res. 1980 Sep;(151):283–293. [PubMed]
  • Dietrich JW, Goodson JM, Raisz LG. Stimulation of bone resorption by various prostaglandins in organ culture. Prostaglandins. 1975 Aug;10(2):231–240. [PubMed]
  • Sudmann E, Bang G. Indomethacin-induced inhibition of haversian remodelling in rabbits. Acta Orthop Scand. 1979 Dec;50(6 Pt 1):621–627. [PubMed]
  • Bo J, Sudmann E, Marton PF. Effect of indomethacin on fracture healing in rats. Acta Orthop Scand. 1976 Dec;47(6):588–599. [PubMed]
  • Nyman S, Schroeder HE, Lindhe J. Suppression of inflammation and bone resorption by indomethacin during experimental periodontitis in dogs. J Periodontol. 1979 Sep;50(9):450–461. [PubMed]
  • Schumacher HR., Jr Articular manifestations of hypertrophic pulmonary osteoarthropathy in bronchogenic carcinoma. Arthritis Rheum. 1976 May-Jun;19(3):629–636. [PubMed]
  • Evans WK. Reversal of hypertrophic osteoarthropathy after chemotherapy for bronchogenic carcinoma. J Rheumatol. 1980 Jan-Feb;7(1):93–97. [PubMed]
  • Rosenthall L, Kirsh J. Observations of radionuclide imaging in hypertrophic pulmonary osteoarthropathy. Radiology. 1976 Aug;120(2):359–362. [PubMed]
  • Segal AM, Mackenzie AH. Hypertrophic osteoarthropathy: a 10-year retrospective analysis. Semin Arthritis Rheum. 1982 Nov;12(2):220–232. [PubMed]
  • Donnelly B, Johnson PM. Detection of hypertrophic pulmonary osteoarthropathy of skeletal imaging with 99mTc-labeled diphosphonate. Radiology. 1975 Feb;114(2):389–391. [PubMed]
  • Ali A, Tetalman MR, Fordham EW, Turner DA, Chiles JT, Patel SL, Schmidt KD. Distribution of hypertrophic pulmonary osteoarthropathy. AJR Am J Roentgenol. 1980 Apr;134(4):771–780. [PubMed]
  • Freeman MH, Tonkin AK. Manifestations of hypertrophic pulmonary osteoarthropathy in patients with carcinoma of the lung. Demonstration by 99mTc-pyrophosphate bone scans. Radiology. 1976 Aug;120(2):363–365. [PubMed]
  • Rao GM, Guruprakash GH, Poulose KP, Bhaskar G. Improvement in hypertrophic pulmonary osteoarthropathy after radiotherapy to metastasis. AJR Am J Roentgenol. 1979 Nov;133(5):944–946. [PubMed]

Articles from The Western Journal of Medicine are provided here courtesy of BMJ Group