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West J Med. 1985 March; 142(3): 345–347.
PMCID: PMC1306024

Indomethacin Therapy for Hypertrophic Pulmonary Osteoarthropathy in Patients With Bronchogenic Carcinoma


Hypertrophic pulmonary osteoarthropathy (HPO) is a disabling complication of lung cancer often requiring thoracotomy with vagotomy for control of pain. This condition was confirmed by scintigraphy in six consecutive patients with biopsy-proved lung cancer. All had characteristic bone and joint pain unresponsive to a variety of analgesics. Treatment with indomethacin gave dramatic relief of pain within 72 hours in all six. Consideration should be given to instituting a controlled trial to establish the efficacy of indomethacin for the treatment of HPO.

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