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J R Soc Med. 2005 December; 98(12): 547–548.
PMCID: PMC1299341

Eliot Slater's myth of the non-existence of hysteria

Mrs T presents to the general neurology clinic on a busy Tuesday morning. She has a 1-year history of right-sided weakness, fatigue, back pain and sleep disturbance and is in a wheelchair. She has a large file full of other symptoms for which no convincing disease explanation has ever been found. Examination confirms inconsistent weakness with a positive Hoover's sign and symmetrical reflexes. Investigations including MRI brain scan are normal. The diagnosis is functional weakness, which might also be called conversion disorder or psychogenic weakness. In years gone by it would have been called ‘hysteria’.

Patients like Mrs T are quite common in neurological practice. A recent study from our group found that patients with weakness unexplained by disease may be as common as those with multiple sclerosis (MS). Furthermore, they are deserving patients with chronic disability and distress.1 But, hang on a minute, do they really exist at all? Was there not a classic paper by Slater that proved that they all received a neurological diagnosis in the end?

Eliot Slater (1904-1983) was founder of the Psychiatric Genetics Unit at the Institute of Psychiatry in 1959 and also held a post at the Institute of Neurology (1946-1959). The paper in question, ‘Diagnosis of “Hysteria”’, was published in the BMJ in 1965.2 It was a lecture transcript which described a follow up study of 112 patients with a diagnosis of ‘hysteria’ seen at the Institute of Neurology an average of nine years earlier.3 Despite its classic status, a cursory read reveals major flaws in its design and reporting. Slater conflates together patients who were truly mis-diagnosed (e.g. someone with ‘hysterical weakness’ who turned out to have an ‘atypical myopathy’) with those who merely had ‘co-morbidity’ (e.g. a patient with MS and ‘hysterical elaboration’ who at follow up had only MS). He did not report clearly what symptoms the patients had, or on what basis they were misdiagnosed. Even some of the apparent misdiagnoses seem to be of dubious relevance (for example, ‘cortical atrophy’). Yet, this was his clear and robust conclusion:

‘No evidence has yet been offered that the patients diagnosed as suffering from “hysteria” are in medically significant terms anything more than a random selection... The only thing that hysterical patients can be shown to have in common is that they are all patients. The malady of the wandering womb began as a myth, and a myth it yet survives. But like all unwarranted beliefs which still attract credence, it is dangerous. The diagnosis of “hysteria” is a disguise for ignorance and a fertile source of clinical error. It is in fact not only a delusion but a snare.’

So why does this paper matter? It matters because of the paper's huge impact on medical science and practice. Despite a fierce rebuke from the neurologist Sir Francis Walshe later that year in the BMJ,4 his conclusion that a diagnosis of hysteria is ‘not only a delusion but a snare’ has resonated down the decades. For the next 30 years, Slater's study turns up again and again in the literature as solid ‘evidence’ that patients with complaints regarded as ‘non-organic’ or evidence of ‘conversion disorder’ are just misdiagnosed cases of disease which will eventually emerge.

Why did it become a classic? Perhaps because it was a blessing for psychiatrists. The typical patient with conversion symptoms is rarely enthusiastic about seeing a psychiatrist. Slater's study provided a wonderful excuse to send the patient back to the neurologist with an opinion that there was ‘no psychiatric disorder’ and that the symptoms would probably turn out to be due to a disease. Neurologists, for their part, appeared to carry on diagnosing ‘hysteria’ but remained uninterested in the topic. Perhaps it became a classic because of the memorable eloquence of the conclusion. Whatever the reason, it was not the quality of the science.

The truth is that reported misdiagnosis rates for symptoms like these were around 15% before his study and have averaged only 4% in studies of patients since 1970, a rate no worse than for any other neurological or psychiatric condition.5 Slater made a valid point about the overly broad use of the word ‘hysteria’ at the time, but he also denied the existence of symptoms such as functional weakness and non-epileptic attacks. In doing so, he unwittingly stunted research and impeded the clinical care of these patients, a situation from which we are only now recovering. Perhaps above all it should remind us how easily we can be led to believe what is convenient and eloquently expressed, rather than what is scientifically true.


1. Stone J, Sharpe M, Deary I, Warlow C. Functional paresis: paradoxes in illness beliefs and disability in 107 subjects [Abstract]. J Neurol Neurosurg Psychiatry 2003;75: 518
2. Slater ET. Diagnosis of ‘hysteria’. BMJ 1965;i: 1395-9 [PMC free article] [PubMed]
3. Slater ET, Glithero E. A follow-up of patients diagnosed as suffering from “hysteria”. J Psychosom Res 1965;9: 9-13 [PubMed]
4. Walshe F. Diagnosis of hysteria. BMJ 1965;ii: 1451-4 [PMC free article] [PubMed]
5. Stone J, Smyth R, Carson A, et al. Systematic review of misdiagnosis of conversion symptoms and “hysteria”. doi:10.1136/bmj.38628.466898.55 (published 13 October 2005) [] accessed 18 October 2005 [PMC free article] [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press