PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of taosLink to Publisher's site
 
Trans Am Ophthalmol Soc. 2000; 98: 101–107.
PMCID: PMC1298216

Incidence of postoperative posterior capsular opacification following treatment with diclofenac 0.1% and ketorolac 0.5% ophthalmic solutions: 3-year randomized, double-masked, prospective clinical investigation.

Abstract

PURPOSE: Laboratory studies in experimental animals suggest that use of nonsteroidal anti-inflammatory drugs decreases the incidence of posterior capsular opacification (PCO) following cataract surgery. Recently the incidence of PCO following cataract surgery and intraocular lens implantation was reported to be no different following postoperative treatment with diclofenac sodium 0.1% (Voltaren, Ciba Vision) or with dexamethasone 0.1% (Maxidex, Alcon). We studied the incidence of PCO in patients following treatment with diclofenac 0.1% and ketorolac tromethamine 0.5% (Acular, Allergan) ophthalmic solutions 3 years after cataract surgery and implantation of a foldable silicone intraocular lens. METHODS: A total of 120 patients underwent phacoemulsification and implantation of a foldable silicone intracular lens. Patients were treated with either diclofenac 0.1% ophthalmic solution or 0.5% ketorolac ophthalmic solution 4 times daily for 30 days in a double-masked, randomized fashion during the postoperative period. Patients were examined 3 years following surgery by a masked observer who determined which patients received YAG capsulotomies and graded any existing PCO. RESULTS: Each treatment group had 12% YAG capsulotomies 3 years following surgery. Although PCO was present more often with diclofenac treatment (25/62) than with ketorolac treatment (16/58), this difference is not statistically significant (P = .142). Patients tolerated both treatments well without a difference in toxic effects or tolerability. CONCLUSIONS: This study did not demonstrate a difference in the ability of diclofenac or ketorolac ophthalmic solutions to prevent PCO following cataract extraction and implantation of an intraocular lens. Both treatment regimens were equally well tolerated.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.1M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Apple DJ, Solomon KD, Tetz MR, Assia EI, Holland EY, Legler UF, Tsai JC, Castaneda VE, Hoggatt JP, Kostick AM. Posterior capsule opacification. Surv Ophthalmol. 1992 Sep-Oct;37(2):73–116. [PubMed]
  • Nishi O, Nishi K, Fujiwara T, Shirasawa E. Effects of diclofenac sodium and indomethacin on proliferation and collagen synthesis of lens epithelial cells in vitro. J Cataract Refract Surg. 1995 Jul;21(4):461–465. [PubMed]
  • Flach AJ, Dolan BJ, Donahue ME, Faktorovich EG, Gonzalez GA. Comparative effects of ketorolac 0.5% or diclofenac 0.1% ophthalmic solutions on inflammation after cataract surgery. Ophthalmology. 1998 Sep;105(9):1775–1779. [PubMed]
  • Sellman TR, Lindstrom RL. Effect of a plano-convex posterior chamber lens on capsular opacification from Elschnig pearl formation. J Cataract Refract Surg. 1988 Jan;14(1):68–72. [PubMed]
  • Tetz MR, Auffarth GU, Sperker M, Blum M, Völcker HE. Photographic image analysis system of posterior capsule opacification. J Cataract Refract Surg. 1997 Dec;23(10):1515–1520. [PubMed]
  • Schaumberg DA, Dana MR, Christen WG, Glynn RJ. A systematic overview of the incidence of posterior capsule opacification. Ophthalmology. 1998 Jul;105(7):1213–1221. [PubMed]
  • Nishi O. Posterior capsule opacification. Part 1: Experimental investigations. J Cataract Refract Surg. 1999 Jan;25(1):106–117. [PubMed]
  • Pande MV, Ursell PG, Spalton DJ, Heath G, Kundaiker S. High-resolution digital retroillumination imaging of the posterior lens capsule after cataract surgery. J Cataract Refract Surg. 1997 Dec;23(10):1521–1527. [PubMed]

Articles from Transactions of the American Ophthalmological Society are provided here courtesy of American Ophthalmological Society