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Ayurveda, the traditional Indian medicine (TIM) and traditional Chinese medicine (TCM) remain the most ancient yet living traditions. There has been increased global interest in traditional medicine. Efforts to monitor and regulate herbal drugs and traditional medicine are underway. China has been successful in promoting its therapies with more research and science-based approach, while Ayurveda still needs more extensive scientific research and evidence base. This review gives an overview of basic principles and commonalities of TIM and TCM and discusses key determinants of success, which these great traditions need to address to compete in global markets.
Ayurveda, the traditional Indian medicine (TIM) and traditional Chinese medicine (TCM) remain the most ancient yet living traditions. These are the two ‘great traditions’ with sound philosophical, experiential and experimental basis. Increased side effects, lack of curative treatment for several chronic diseases, high cost of new drugs, microbial resistance and emerging diseases are some reasons for renewed public interest in complementary and alternative medicines (1). It has been postulated that by 2010 at least two-thirds of the United States population will be using one or more of the alternative therapeutic approaches. Use of indigenous drugs of natural origin forms a major part of such therapies; more than 1500 herbals are sold as dietary supplements or ethnic traditional medicines (2). Pharmaceutical companies have renewed their strategies in favor of natural product drug development and discovery (3). For instance, in Europe, AnalytiCon Discovery has stressed on drug discovery based on natural product chemistry (4). In the Asia-Pacific region, MerLion Pharmaceuticals in Singapore has comprehensive structures and capabilities necessary for natural product-based drug discovery (5). China has successfully promoted its own therapies over the globe with a science-based approach. Growing popularity of TCM can be evidenced by the rapid increase in number of licensed Chinese medicine providers in the United States. The Chinese government has pledged to create several export-oriented TCM giants in the coming years (6). Continuous efforts in promotion of the indigenous therapies by China have put TCM in a commendable position. Global acceptance of Ayurveda is gearing up and there has been a steep rise in the demand for medicinal plants from India (7). The Pharmaceutical Research and Development Committee report of Ministry of Chemicals, Government of India also underscores the importance of traditional knowledge (8). The increasing use of traditional therapies demands more scientifically sound evidence for the principles behind therapies and for effectiveness of medicines. Recent advancements in the analytical and biological sciences, along with innovations in genomics and proteomics can play an important role in validation of these therapies. Western scientific community views traditional medicines cautiously and stress the concerns related to research, development and quality (9,10). This review delineates the challenges that TCM and TIM need to address to become more acceptable to the world community.
The global pharmaceutical market was worth US $550 billion in 2004 (11) and is expected to exceed US $900 billion by the year 2008. The herbal industry shares about US $62 billion with good growth potential. The World Bank reports trade in medicinal plants, botanical drug products and raw materials is growing at an annual growth rate between 5 and 15% (12). Within the European community, botanical medicine represents an important share of the pharmaceutical market (13); the nutraceutical sector is also growing rapidly. In 2001, US $17.8 billion was spent in the United States on dietary supplements, US $4.2 billion of it for botanical remedies (14). In India the value of botanicals related trade is about US $10 billion per annum with annual export of US $1.1 billion (15) while China's annual herbal drug production is worth US $48 billion with export of US $3.6 billion (16). Presently, the United States is the largest market for Indian botanical products accounting for about 50% of the total exports. Japan, Hong Kong, Korea and Singapore are the major importer of TCM taking 66% share of China's botanical drugs export (17).
Globally, there have been concerted efforts to monitor quality and regulate the growing business of herbal drugs and traditional medicine. Health authorities and governments of various nations have taken an active interest in providing standardized botanical medications. United States Congress has fuelled rapid growth in the nutraceutical market with passage of the Dietary Supplement Health and Education Act in 1994. US Food and Drug Administration (FDA) has recently published the International Conference on Harmonization guidance Common Technical Document addressing concerns related to quality of medicines that also includes herbals (18). The National Center for Complementary and Alternative Medicine has been inaugurated as the United States Federal Government's lead agency for scientific research in this arena of medicine. Its mission is to explore complementary and alternative healing practices in the context of rigorous science, support sophisticated research, train researchers, disseminate information to the public on the modalities that work and explain the scientific rationale underlying discoveries. The center is committed to explore and fund all such therapies for which there is sufficient preliminary data, compelling public health need and ethical justifications (19,20). World Health Organization (WHO) is keen regarding traditional medicine and has been active in creating strategies, guidelines and standards of botanical medicines (21). The global scenario illustrates vividly both promise and challenges presented by the traditional medicines. India needs to identify the extent to which Ayurvedic therapeutics is safe and effective so that it could get wide global acceptance.
Ayurveda and TCM have many commonalities. The focus of both the systems is on the patient rather than disease. Both systems fundamentally aim to promote health and enhance the quality of life, with therapeutic strategies for treatment of specific diseases or symptoms in holistic fashion. Almost half of the botanical sources used as medicines have similarities; moreover, both systems have similar philosophies geared towards enabling classification of individuals, materials and diseases. TCM considers the human at the center of the universe as an antenna between celestial and earthly elements. Water, earth, metal, wood and fire are the five elements of the material world. The world is a single unit and its movement gives rise to yin and yang, the two main antithetic aspects. The actual meaning of the term yin and yang is ‘opposites’, such as the positive and the negative. However, Chinese believe that yin and yang is not absolute but relative. Consistent with the modern view of homeostasis, yin and yang are interchanged to meet the view that ‘yang declines and yin rises’ or ‘yang is raised to produce a decline of yin’. The four bodily humors (qi, blood, moisture and essence) and internal organ systems (zang fu) play an important role in balancing the yin and yang in human body. Proper formation, maintenance and circulation of these energies are essential for health. When the two energies fall out of harmony, disease develops. The physician takes into account this concept while treating patients. Drugs or herbs are used to correct this imbalance of yin–yang in the human body (22,23).
Ayurveda considers that the universe is made up of combinations of the five elements (pancha mahabhutas). These are akasha (ether), vayu (air), teja (fire), aap (water) and prithvi (earth). The five elements can be seen to exist in the material universe at all scales of life and in both organic and inorganic things. In biological system, such as humans, elements are coded into three forces, which govern all life processes. These three forces (kapha, pitta and vata) are known as the three doshas or simply the tridosha. Each of the doshas is composed of one or two elements. Vata is composed of space and air, Pitta of fire, and kapha of water and earth. Vata dosha has the mobility and quickness of space and air; pitta dosha the metabolic qualities of fire; kapha dosha the stability and solidity of water and earth. The tridosha regulates every physiological and psychological process in the living organism. The interplay among them determines the qualities and conditions of the individual. A harmonious state of the three doshas creates balance and health; an imbalance, which might be an excess (vriddhi) or deficiency (kshaya), manifests as a sign or symptom of disease (24,25) (Figs 1 and and22).
Consistency in composition and biological activity are essential requirements for the safe and effective use of therapeutic agents. Quality is the critical determinant of safety and efficacy of botanical medicines; however, botanical preparations rarely meet the standards of quality, which refers to procedures and markers for assessing and verifying the strength of botanical raw materials or extracts or formulations thereof (26). Chromatographic techniques and chemical marker assisted characterization of the botanicals does not ensure consistent biological activity or stability (27). Therefore, production of quality botanical medicines has become a challenge to regulatory authorities, scientific organizations and manufacturers. WHO (28), USFDA (29), European Scientific Cooperative on Phytomedicine (ESCOP) (30) have published standard sets of guidelines to address the concerns. Some of the progressive manufacturers follow them to provide standardized botanical medicine. In India, about 9000 licensed units manufacture traditional medicines with or without proper standardization (31). Indian manufacturers generally follow WHO guidelines for quality control. Adulteration of market samples remains a major problem in domestic and export markets of Indian herbal products. Chemical analysis of some antiarthritic medicines from Ayurveda has led to a finding that synthetic anti-inflammatory drugs like phenylbutazone, indomethacin and/or corticosteroids have been added (32). Heavy metals such as mercury, arsenic and lead contamination has also become a critical problem (33,34). Market botanicals are stored under undesirable conditions over the years and may have contamination or adulteration of other materials, which thereby adversely affect the efficacy and sometimes even add to toxicity. Lack of proper processing of the materials even by pharmaceutical firms contributes to decline of the herbal business. Availability of the desired genotype of plant in the required quantity, free from toxic contaminants and with desired therapeutic activity have also become a critical issue (35). China has successfully overcome such difficulties by modernizing its traditional medicine profession with government-sponsored Good Agricultural Policies (GAPs) and Good Manufacturing Practices (GMPs). GAPs stresses selection of the correct germplasm with high content of stable active components. The cultivation practices offer Standard Operating Procedures for use of fertilizers, irrigation systems and disease management allied with insects and pest prevention and cure. GAPs also establish standards for noxious and harmful contaminants like heavy metals, pesticide residues and microbes in plants. All manufactures of TCM are mandated to comply with guidelines laid down by China's State Drug Administration (SDA) by 2004 and farms producing raw ingredients must comply with SDA-imposed standards by 2007. As a result, 1470 companies have qualified for GMPs while 570 failed to meet the standards (36). For marketing of herbal medicine in China, special requirements such as quality dossier, safety and efficacy evaluation and specific labeling criteria are required. New herbal drugs must be approved according to the Drug Administration Laws.
Similar integrated efforts are needed to raise the image of Ayurvedic medicines in the global business. Government of India has promulgated GMP regulations for traditional systems of medicines to improve the quality and standard of Ayurvedic, Siddha and Unani drugs in pharmacies. New rules delineating essential infrastructure, manpower and quality control requirements came into force from 2000 and form part of the Drugs and Cosmetics Act, 1940 (37). Licensing of Ayurvedic medicine is also governed under drug and cosmetics act, 1940. Ayurvedic Patent and Proprietary medicines need to contain only the ingredients mentioned in the recommended books as specified in the Act. For any new herbal medicine safety and efficacy data are mandatory. Depending on nature of herbs and market availability, different requirements exist for submission of clinical trial and safety data.
Standardization of herbal drugs is not just an analytical operation for identification and assay of active principles; rather, it comprises total information and controls to necessarily guarantee consistent composition of all herbals. A good example of this is a polyherbal formulation (Artrex®) designed for the treatment of arthritis that contains four botanicals. The formulation, standardized using modern scientific tools and with known markers, has been granted a US patent (38). Validated agro-industrial technologies should be applied for cultivation and processing of medicinal plants and manufacturing of herbal medicines. Indian herbal drug industry needs to ensure procurement of standardized authentic raw material free from toxic contaminants. Improving processing technologies, conducting all operations under GMP compliance and maintenance of in-process quality control for manufacturing quality herbal products also need evidence for therapeutic efficacy, safety and shelf life. Such approaches remain important in global promotion of Ayurveda.
In China and India formal training is an integral part of the national health program, which helps in ensuring quality standards in health care delivery. China became successful in integrating TCM in the national health care system. Science-based approaches were utilized and inculcated in the education of TCM with emphasis on research. Hospitals practicing TCM treat more than 200 million outpatients and almost 3 million inpatients annually. About 95% of general hospitals in China have traditional medicine departments (39).
Government of India also has expressed support and encouragement for the TIM. A separate department for Indian Systems of Medicine and Homeopathy (ISM&H) now known as AYUSH (Ayurveda, Yoga, Unani, Siddha, Homoeopathy) was established in March 1995 to promote indigenous systems. Priorities include education, standardization of drugs, enhancement of availability of raw materials, research and development, information, communication and larger involvement in the national system for delivering health care. The Central Council of Indian Medicine oversees teaching and training institutes while Central Council for Research in Ayurveda and Siddha deals with interdisciplinary research. Some TIM products are being added into family welfare programs of the government under the World Bank project. These medicines are mainly for common diseases like anemia, edema during pregnancy, postpartum problems such as pain, uterine and abdominal complications, difficulties with lactation, nutritional deficiencies and childhood diarrhea (40). The government has also established 10 new drug testing laboratories for TIM and is upgrading existing laboratories to provide documented high quality evidence to licensing authorities for the safety and quality of herbal medicines. This replaces the earlier ad hoc system of testing that was considered unreliable. In 2002, the Council for Scientific and Industrial Research has launched a research program under New Millennium Indian Technology Leadership Initiative scheme in Ayurveda identifying three disease areas such as arthritis, diabetes and hepatic disorders, which afflict large numbers of the Indian population.
Many additional concerns need to be addressed. The quality of education in many colleges needs to be improved. Under the pretext of integration, attempts to make hybrid curricula producing inadequately trained graduates remain unacceptable for either modern or traditional systems (41). A paucity of funds is noticeable; ISM&H gets only 2% of the total health budget of the nation. A corrective and promotive policy needs to be initiated for TIM to fully realize its potential and contribute more meaningfully to integrative health services. The industry has not been able to grow and develop optimally during the last few decades. Largely, the achieved growth is owing to industry's own initiatives, in-house research and development. A national organization, Ayurvedic Drugs Manufacturers' Association is taking a proactive role to improve quality and research that needs to be nurtured, stimulated and sustained by providing special funding or incentives. Preparation of formularies and pharmacopoeial standards have been attempted but a lot remains to be done. Numbers of Indian botanical sources and their medicinal uses as in case of turmeric have been patented by claiming innovations that are already in the public domain. Necessary measures to protect such intellectual property are important as the retrieval and contesting of patents is a very costly and time-consuming affair (42). For this purpose, the Government of India has established a Traditional Knowledge Digital Library on traditional medicinal plants, which will also lead to a Traditional Knowledge Resource Classification (43). Linking this to internationally accepted International Patent Classification system will mean building the bridge between the knowledge contained in an old Sanskrit text and a patent examiner. This may control the problem of mistakingly granting patents since the examiner will know the Indian rights to that knowledge. It could integrate widely scattered and distributed references on TIM in retrievable form and will be a major impetus to modern research in the developing world.
Natural products extracts of therapeutic relevance are of paramount importance as reservoirs of structural and chemical diversity. A recent review on national pharmacopoeias from several countries reveals at least 120 distinct chemical substances from different plants that have utility as lifesaving drugs (44). This has been achieved through chemical and pharmacological screening of only 6% of the total plant species. Untapped, hidden wealth in the flora needs to be unearthed and explored to cure diseases like AIDS, cancer, diabetes, etc. Recently, NIH has started extensive research for anti-inflammatory compounds from turmeric, ginger and boswellia with the aid of Ayurvedic knowledge. Screening of different plants for novel anticancer compounds is also in progress with reference experiential data from traditional systems (45). Botanical immunodrugs from traditional medicine can provide newer opportunities to bioprospect diverse and synergistic chemical moieties, which in combination might act on multiple targets and improve the therapeutic spectrum (46). PUBMED, Google scholar and Science direct are the widely recognized web databases of scientific literature. We have given comparative citations for Indian and Chinese medicine using different key words and also provided the patent data of USPTO. Visibility of Ayurvedic medicine remains much lower as compared with TCM (Table 1).
Chinese medicine became successful in crossing philosophical barriers through constant reworking of the basic system. The first compound derived from Chinese herbal remedies to enter the western market was ephedrine, an amphetamine-like stimulant from ma huang (Ephedra sinica). The next was artimisinin, a potent antimalarial from qinghao (Artemisia annua). In 2003, Chinese researchers launched a phase II trial to test the efficacy of a drug called kanglaite from iijen (Coix lachryma-jobi) for treating non-small-cell lung cancer (47). This is the first drug from TCM to enter clinical trials in the United States. Other drug molecules from TCM are xue baoPG2 (general tonic from Astragalus membracaceus) and camptothecin analogs as CPT11 and topotecan (anticancer from Camptotheca accuminata), which have a huge market. In 2002, 1141 different traditional plant drugs were registered for their therapeutic activities including several new single compounds from plants as arteannuin (antimalarial), indirubin (anticancer), etc. One of the twelve focal points in the current Five-Year Plan of China's Ministry of Science and Technology is to modernize research in TCM. Pharmacopoeia of the People's Republic of China (2000) (48) contains 992 monographs of Chinese crude drugs and traditional Chinese patent medicines in which 76 new admissions and 248 monographs have been revised. Controlled clinical trials have been initiated at several hospitals and research organizations to prove the efficacy and safety of the Chinese medicine (49,50). Recent reports on adverse effects of drug like ma huang (51) and gingko (52) have sounded a cautionary note that promoting traditional medicine from conception to commercialization will not be easy.
India has world-class expertise and facilities for organic synthesis, isolation and structure elucidation, biological screening, toxicological testing and pharmacokinetics. This is supplemented by the expertise for development of agro-technology for cultivation of medicinal plants. Industry participation to ensure successful upscaling and implementation of technology is increasing. Generation of leads with structural diversities through creation of natural product libraries, identification of proper targets and their proper validation and optimization is of paramount importance (53). India has progressive research institutes like Central Drug Research Institute (CDRI), Central Institute of Medicinal and Aromatic Plants and National Botanical Research Institute at Lucknow, Regional Research Laboratories (RRL), at Jammu, Bhubaneshwar and Jorhat, National Chemical Laboratory at Pune, which routinely undertake research on medicinal plants. Most of them are involved in standardizing the herbal medicines and isolating active compounds. Few selected crops have been taken for improvement yet there is a need for research on quality planting materials for farmers, conservation of endangered species and to prevent exploitation of the natural resources. Reserpine (antihypertensive from rauwolfia) is an extremely valuable contribution from Ayurvedic systems. Curcumin (54) (anti-inflammatory from turmeric), withaferin A (55) (anti-inflammatory from ashwagandha), kutkoside (56) (hepatoprotective from kutki), andrographolide (57) (hepatoprotective from andrographis) and vasicine (58) (bronchodilator and expectorant from vasaka) are chemical entities with attractive scaffolds for drug discovery.
Controlled clinical trials are important to develop evidence for safety and efficacy. Results from clinical trials are encouraging (59), but lot more clinical research is required to establish validity of the system. Ayurvedic preparations have been successfully evaluated for treatment of bronchial asthma (60,61), rheumatoid arthritis (62), ischaemic heart disease (63,64). Piperine from pipali has come out as a bioenhancer in recent clinical evaluation (65,66). Botanicals like Withania somnifera (67); Asparagus racemosus (68) have exhibited significant vaccine adjuvant activity in experimental systems, which have valuable applications in immunobiological industry. An IND application of Lupin Ltd. is in process and a US patent has been granted for development of herbal-based antipsoriatic composition containing Argemone mexicana (69). Standardized fraction of gugulipid from Commiphora wightii developed by CDRI has been marketed (Guglip®, Cipla Ltd) for treating hyperlipidemia and atheriosclerosis (70). RRL Jammu has commercialized Boswellia serrata gum resin as NSAID (Non-Steroidal Anti-Inflammatory Drug) (Sallaki® Gufic). It is also hypolipidemic.
A multicentric study by the Indian Council of Medical Research (ICMR) showed promising results that a preparation from Pterocarpus marsupium was effective in reducing levels of blood glucose and glycosylated haemoglobin in patients with non-insulin-dependent diabetes mellitus (71). Analysis of most frequently used plant based therapies in Ayurvedic system revealed that 43% of them have been tested on humans while 62% have been the subject of one or more animal studies. Among these drugs having sufficient clinical data are guggul, brahmi, ashwagandha, amlaki, guduchi, kutki, shatavari and shunthi (72) Pharmacopoeia of India (1996) (73) covers few botanical monographs like clove, guggul, opium, mentha, senna, and ashwagandha. The Ayurvedic Pharmacopoeia of India gives monographs for 258 different Ayurvedic drugs. The standards mentioned are quite inadequate to build quality of the botanical materials (74). Indian Drug Manufacturers Association has published Indian Herbal Pharmacopoeia (2002) (75) with 52 monographs on widely used medicinal plants growing in India where scientific data have been incorporated.
Harmonization and validation of the complex process of Ayurvedic therapeutics remain important. Novel efforts like Ayugenomics (76) aim to understand Ayurvedic concept of Prakruti from pharmcogenomics perspective to provide a base for human classification, diagnostics and customized medicine (77). Projects like AyuSoft (78) aim to develop intelligent and interactive software based on Ayurvedic classics as a decision support system. New analytical approaches like Herboprint (79) use three-dimensional HPLC and attempt to develop tools for activity-based standardization of botanicals.
Apart from the drug manufacturer, many other supporting industries play important roles in commerce of traditional medicine. The whole pipeline covers collectors and breeders, dealers of the plant materials, processing and manufacturing industry, practitioners of traditional medicine and finally the consumers. Presently, Indian systems of medicine use more than 1100 medicinal plants of which most are collected from the wild. More than 60 species are in great demand (80). The tribal belt of India is rich in these plants and the tribes mainly depend on this trade for livelihood. There are ample of opportunities for adulteration and contamination in the process. Thus, the adequate availability of quality raw materials free from adulterants at reasonable prices have become a big problem for industry and the demand is increasing every year. However, very few efforts have been made either by government or by industry to seriously study the supply and demand. Similar to China, India needs to follow GAPs to ensure the use of correct raw materials and cover the entire life cycle including the harvesting, processing, transportation and storage. Chinese government has developed more than 100 research units and encouraged private enterprises to build over 600 standard planting bases for herbs in great demand. Selection of the correct germplasm using modern DNA fingerprinting and chemoprofiling techniques is also a priority (81). India is emerging as a leader in generic drugs and is exporting them to developed countries. This is a result of adopting standard guidelines and GMPs. However, TIM has yet to capitalize on the quality herbal medicine where GAPs are.
New experiments are beginning to emerge on benefit sharing models for indigenous innovation. For example, Trichopus zeylanicus, found in the tropical forests of southwestern India was collected by the ‘Kani’ tribal people (a traditionally nomadic community from the forests of the Agasthyamalai hills in the Thiruvananthapuram district of Kerala, India). Scientists at the Tropical Botanic Garden and Research Institute (TBGRI) in Kerala discovered uses of this plant that are claimed to boost the immune system. Chemical and pharmacological investigations carried out initially at RRL, Jammu and later at TBGRI showed that the leaves of the plant contained various glycolipids and some other non-steroidal compounds with profound adaptogenic and immune-enhancing properties (82,83). The fruits showed mainly antifatigue properties. TBGRI was successful in developing a scientifically validated and standardized herbal drug, based on the tribal lead (84). The drug was named ‘Jeevani’ and Arya Vaidya Pharmacy released it for commercial production in 1995 (85). TBGRI agreed to equally share the royalty with the tribal community. This experiment was acknowledged by UNDP by conferring a special award to the concerned scientists (86).
Numerous drugs have entered the international market through exploration of ethnopharmacology and traditional medicine. Progress in genomics and proteomics has opened new gateways in therapeutics and drug discovery and development. Better understanding of the human genome has helped in understanding scientific basis of individual variation. Drug targets have evolved during the last decade, but the industry remains target-rich and lead-poor trapped in the old mindset and strategies. TIM and TCM, carry many generations' observations that have well-organized and documented data (87). Although scientific studies have been done on a large number of Indian botanicals, a considerably smaller number of marketable drugs or phytochemical entities have entered the evidence-based therapeutics. China has successfully promoted its own therapies and drugs like ginseng, ma huang and gingko with scientific evidences acceptable for the global community. Approach of integrative medicine by selective incorporation of elements of TCM alongside the modern methods of diagnosis has achieved a great success in China (88).
India needs a clear policy for such integration without compromise on the strategies that are science-based. Efforts are needed to establish and validate pharmacoepidemiological evidence regarding safety and practice of Ayurvedic medicines (89). Pharmacoeconomic studies on TIM and TCM are rare, but can help in understanding cost-effectiveness and cost-benefit of traditional medicine. In all such attempts, TCM examples would help India at various levels including policies, quality standards, integration practices, research models and the complementary integration where public health is kept at the central position. Both TIM and TCM are great traditions with strong philosophical basis and could play an important role in new therapies, drug discovery and development processes.
We thank Council for Scientific and Industrial Research, New Millennium Indian Technology Leadership Initiative Herbal Drug Development Group for discussions. Financial assistance from the University Grants Commission to one of the authors (D.W.) is also gratefully acknowledged.