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J R Soc Med. 1999 May; 92(5): 237–238.
PMCID: PMC1297174

No association of Chlamydia with abortion.


Case reports and serological work have raised the possibility that chlamydias can infect the placenta and thus harm the fetus. We investigated the involvement of Chlamydia in a series of 195 unselected cases of spontaneous abortion or miscarriage. Formalin-fixed placental tissues from all cases were examined immunohistochemically, for the presence of chlamydial lipopolysaccharide, as well as histopathologically. A serum sample was collected from 187 of the patients for detection of anti-chlamydial antibodies by microimmunofluorescence. All placental sections were negative for chlamydial antigen. Serological findings indicated that 8 patients had been in contact with C. trachomatis, 15 patients with C. pneumoniae, and none with C. psittaci. A few cases of perivillitis or intervillitis were detected, but none exhibited the intracytoplasmic inclusions typical of C. psittaci. Although these results are negative a search for Chlamydia in abortion materials should be encouraged.

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Selected References

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  • Hyde SR, Benirschke K. Gestational psittacosis: case report and literature review. Mod Pathol. 1997 Jun;10(6):602–607. [PubMed]
  • Gencay M, Puolakkainen M, Wahlström T, Ammälä P, Mannonen L, Vaheri A, Koskiniemi ML. Chlamydia trachomatis detected in human placenta. J Clin Pathol. 1997 Oct;50(10):852–855. [PMC free article] [PubMed]
  • Fejgin MD, Cohen I, Horvat-Kohlmann M, Charles AG, Luzon A, Samra Z. Chlamydia trachomatis infection during pregnancy: can it cause an intrauterine infection? Isr J Med Sci. 1997 Feb;33(2):98–102. [PubMed]
  • Gregory DW, Schaffner W. Psittacosis. Semin Respir Infect. 1997 Mar;12(1):7–11. [PubMed]
  • Wang SP, Grayston JT. Human serology in Chlamydia trachomatis infection with microimmunofluorescence. J Infect Dis. 1974 Oct;130(4):388–397. [PubMed]
  • Smith IW, Morrison CL, Lee RJ, Brown MI, Lowles IE, Helm CW. Serological survey of chlamydial antibody in post-natal sera. J Infect. 1997 Nov;35(3):277–282. [PubMed]
  • McKinlay AW, White N, Buxton D, Inglis JM, Johnson FW, Kurtz JB, Brettle RP. Severe Chlamydia psittaci sepsis in pregnancy. Q J Med. 1985 Oct;57(222):689–696. [PubMed]
  • Wong SY, Gray ES, Buxton D, Finlayson J, Johnson FW. Acute placentitis and spontaneous abortion caused by chlamydia psittaci of sheep origin: a histological and ultrastructural study. J Clin Pathol. 1985 Jun;38(6):707–711. [PMC free article] [PubMed]
  • Buxton D. Potential danger to pregnant women of Chlamydia psittaci from sheep. Vet Rec. 1986 May 3;118(18):510–511. [PubMed]
  • Herring AJ, Anderson IE, McClenaghan M, Inglis NF, Williams H, Matheson BA, West CP, Rodger M, Brettle PP. Restriction endonuclease analysis of DNA from two isolates of Chlamydia psittaci obtained from human abortions. Br Med J (Clin Res Ed) 1987 Nov 14;295(6608):1239–1239. [PMC free article] [PubMed]

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