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J R Soc Med. 1996 December; 89(12): 694–698.
PMCID: PMC1296033

Anogenital lichen sclerosus in women.

Abstract

A study of 350 women with lichen sclerosus, originally made to elucidate the relationship between lichen sclerosus and autoimmunity, led to the amassing of a considerable amount of clinical material. Our review is confined to those with anogenital lesions (342), supplemented by some new cases (15), giving a total of 357 women with biopsy proven lichen sclerosus. It demonstrates the wide age range of the condition, the association with morphoea and lichen planus and the occurrence of squamous cell carcinoma in some cases. It also shows that inappropriate surgery has continued to be carried out for benign disease.

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Selected References

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  • Meyrick Thomas RH, Ridley CM, McGibbon DH, Black MM. Lichen sclerosus et atrophicus and autoimmunity--a study of 350 women. Br J Dermatol. 1988 Jan;118(1):41–46. [PubMed]
  • Wallace HJ. Lichen sclerosus et atrophicus. Trans St Johns Hosp Dermatol Soc. 1971;57(1):9–30. [PubMed]
  • Ridley CM. Genital lichen sclerosus (lichen sclerosus et atrophicus) in childhood and adolescence. J R Soc Med. 1993 Feb;86(2):69–75. [PMC free article] [PubMed]
  • Meyrick Thomas RH, Kennedy CT. The development of lichen sclerosus et atrophicus in monozygotic twin girls. Br J Dermatol. 1986 Mar;114(3):377–379. [PubMed]
  • Marren P, Yell J, Charnock FM, Bunce M, Welsh K, Wojnarowska F. The association between lichen sclerosus and antigens of the HLA system. Br J Dermatol. 1995 Feb;132(2):197–203. [PubMed]
  • Marren P, Millard P, Chia Y, Wojnarowska F. Mucosal lichen sclerosus/lichen planus overlap syndromes. Br J Dermatol. 1994 Jul;131(1):118–123. [PubMed]
  • Connelly MG, Winkelmann RK. Coexistence of lichen sclerosus, morphea, and lichen planus. Report of four cases and review of the literature. J Am Acad Dermatol. 1985 May;12(5 Pt 1):844–851. [PubMed]
  • Patterson JA, Ackerman AB. Lichen sclerosus et atrophicus is not related to morphea. A clinical and histologic study of 24 patients in whom both conditions were reputed to be present simultaneously. Am J Dermatopathol. 1984 Aug;6(4):323–335. [PubMed]
  • Stiller M, Klein W, Dorman R, Albom M. Bilateral vulvar basal cell carcinomata. J Am Acad Dermatol. 1993 May;28(5 Pt 2):836–838. [PubMed]
  • Thomas RH, McGibbon DH, Munro DD. Basal cell carcinoma of the vulva in association with vulval lichen sclerosus et atrophicus. J R Soc Med. 1985;78 (Suppl 11):16–18. [PMC free article] [PubMed]
  • Leibowitch M, Neill S, Pelisse M, Moyal-Baracco M. The epithelial changes associated with squamous cell carcinoma of the vulva: a review of the clinical, histological and viral findings in 78 women. Br J Obstet Gynaecol. 1990 Dec;97(12):1135–1139. [PubMed]
  • Ridley CM. The aetiology of vulval neoplasia. Br J Obstet Gynaecol. 1994 Aug;101(8):655–657. [PubMed]
  • Crum CP. Carcinoma of the vulva: epidemiology and pathogenesis. Obstet Gynecol. 1992 Mar;79(3):448–454. [PubMed]
  • Haefner HK, Tate JE, McLachlin CM, Crum CP. Vulvar intraepithelial neoplasia: age, morphological phenotype, papillomavirus DNA, and coexisting invasive carcinoma. Hum Pathol. 1995 Feb;26(2):147–154. [PubMed]
  • Tan SH, Derrick E, McKee PH, Hobbs C, Ridley M, Neill S. Altered p53 expression and epidermal cell proliferation is seen in vulval lichen sclerosus. J Cutan Pathol. 1994 Aug;21(4):316–323. [PubMed]
  • Newton JA, Camplejohn RS, McGibbon DH. A flow cytometric study of the significance of DNA aneuploidy in cutaneous lesions. Br J Dermatol. 1987 Aug;117(2):169–174. [PubMed]
  • Meffert JJ, Davis BM, Grimwood RE. Lichen sclerosus. J Am Acad Dermatol. 1995 Mar;32(3):393–418. [PubMed]

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