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J R Soc Med. 1996 March; 89(3): 153P–154P.
PMCID: PMC1295701

The Canadian Familial Adenomatous Polyposis Registry: past, present and future.


The advent of the molecular world opening up for familial adenomatous polyposis and other genetically predisposed cancers has now provided us with wonderful tools to study these diseases. The challenges, however, clearly remain to transfer discoveries in the laboratory to improvements in the care of these patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bapat B, Odze R, Mitri A, Berk T, Ward M, Gallinger S. Identification of somatic APC gene mutations in periampullary adenomas in a patient with familial adenomatous polyposis (FAP). Hum Mol Genet. 1993 Nov;2(11):1957–1959. [PubMed]
  • Bapat BV, Parker JA, Berk T, Cohen Z, McLeod RS, Ray PN, Stern HS. Combined use of molecular and biomarkers for presymptomatic carrier risk assessment in familial adenomatous polyposis: implications for screening guidelines. Dis Colon Rectum. 1994 Feb;37(2):165–171. [PubMed]
  • Berk T, Cohen Z, Cullen JB. Familial polyposis and the role of the preventive registry. Can Med Assoc J. 1981 Jun 1;124(11):1427–1428. [PMC free article] [PubMed]
  • Parker JA, Kalnins VI, Deck JH, Cohen Z, Berk T, Cullen JB, Kiskis AA, Ke WJ. Histopathological features of congenital fundus lesions in familial adenomatous polyposis. Can J Ophthalmol. 1990 Apr;25(3):159–163. [PubMed]
  • Levitt AJ, Rodin G, Cohen Z, Berk T. Coping styles, psychopathology and intellectual performance in patients with familial adenomatous polyposis. Gen Hosp Psychiatry. 1992 Jan;14(1):61–68. [PubMed]
  • Berk T, Cohen Z, McLeod RS, Stern HS. Management of mesenteric desmoid tumours in familial adenomatous polyposis. Can J Surg. 1992 Aug;35(4):393–395. [PubMed]
  • Fishel R, Lescoe MK, Rao MR, Copeland NG, Jenkins NA, Garber J, Kane M, Kolodner R. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell. 1993 Dec 3;75(5):1027–1038. [PubMed]

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