Search tips
Search criteria 


Logo of jrsocmedLink to Publisher's site
J R Soc Med. 1991 November; 84(11): 646–649.
PMCID: PMC1295464

A novel approach to anxiolytic premedication for day-case patients.


The usefulness of 10 mg timolol orally as a non-sedative anxiolytic premedicant for day-case patients was examined in a double-blind placebo-controlled study. Patients were invited to take part by letter sent the week before gynaecological (n = 40) or oral (n = 60) surgery was scheduled. Indices of anxiety and alertness were obtained prior to administration of the tablet; quality of previous anaesthetic experience was also recorded. In those patients with no previous or unpleasant previous anaesthetic experience a significant reduction in anxiety amongst those given timolol was identified. Haemodynamic differences between the groups were not clinically significant, and return of psychomotor function was not delayed by timolol. Timolol effectively reduces situational anxiety, is non-sedative, and is advocated as a premedicant for anxious day-case patients and others in whom rapid return of psychomotor function is desirable.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (843K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Greenwood BK, Bradshaw EG. Preoperative medication for day-case surgery. A comparison between oxazepam and temazepam. Br J Anaesth. 1983 Oct;55(10):933–937. [PubMed]
  • Beechey AP, Eltringham RJ, Studd C. Temazepam as premedication in day surgery. Anaesthesia. 1981 Jan;36(1):10–15. [PubMed]
  • Thomas D, Tipping T, Halifax R, Blogg CE, Hollands MA. Triazolam premedication. A comparison with lorazepam and placebo in gynaecological patients. Anaesthesia. 1986 Jul;41(7):692–697. [PubMed]
  • Nightingale JJ, Norman J. A comparison of midazolam and temazepam for premedication of day case patients. Anaesthesia. 1988 Feb;43(2):111–113. [PubMed]
  • Raybould D, Bradshaw EG. Premedication for day case surgery. A study of oral midazolam. Anaesthesia. 1987 Jun;42(6):591–595. [PubMed]
  • ZUCKERMAN M. The development of an affect adjective check list for the measurement of anxiety. J Consult Psychol. 1960 Oct;24:457–462. [PubMed]
  • Simpson KH, Stakes AF. Effect of anxiety on gastric emptying in preoperative patients. Br J Anaesth. 1987 May;59(5):540–544. [PubMed]
  • Turner P, Granville-Grossman KL. Effect of adrenergic receptor blockade of the tachycardia of thyrotoxicosis and anxiety state. Lancet. 1965 Dec 25;2(7426):1316–1318. [PubMed]
  • Peet M. Beta-blockade in anxiety. Postgrad Med J. 1984;60 (Suppl 2):16–18. [PubMed]
  • Goldmann L, Ogg TW, Levey AB. Hypnosis and daycase anaesthesia. A study to reduce pre-operative anxiety and intra-operative anaesthetic requirements. Anaesthesia. 1988 Jun;43(6):466–469. [PubMed]
  • deSwiet M. Antihypertensive drugs in pregnancy. Br Med J (Clin Res Ed) 1985 Aug 10;291(6492):365–366. [PMC free article] [PubMed]
  • Edwards IS. Premedication with beta-blocking agents for vasectomy operations. Med J Aust. 1986 Jun 9;144(12):670–670. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press