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J R Soc Med. 1995 November; 88(11): 637–638.
PMCID: PMC1295388

Depressive disorder due to craniopharyngioma.


Secondary causes of depression are legion, and must always be considered in patients presenting with features atypical of primary idiopathic depressive disorder. The case described is that of a middle-aged woman presenting initially with a major depressive disorder who was subsequently found to have a craniopharyngioma, leading to a revised diagnosis of mood disorder due to the tumour. Some features of the presentation might have led to earlier diagnosis had their localizing significance been recognized. Diencephalic lesions should always be considered in patients presenting with the hypersomnic-hyperphagic variant of depressive disorder.

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Selected References

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  • Reeves AG, Plum F. Hyperphagia, rage, and dementia accompanying a ventromedial hypothalamic neoplasm. Arch Neurol. 1969 Jun;20(6):616–624. [PubMed]
  • Burkle FM, Jr, Lipowski ZJ. Colloid cyst of the third ventricle presenting as psychiatric disorder. Am J Psychiatry. 1978 Mar;135(3):373–374. [PubMed]
  • WILLIAMS M, PENNYBACKER J. Memory disturbances in third ventricle tumours. J Neurol Neurosurg Psychiatry. 1954 May;17(2):115–123. [PMC free article] [PubMed]
  • RUSSELL RW, PENNYBACKER JB. Craniopharyngioma in the elderly. J Neurol Neurosurg Psychiatry. 1961 Feb;24:1–13. [PMC free article] [PubMed]

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