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J R Soc Med. 1995 October; 88(10): 597P–598P.
PMCID: PMC1295367

Ocular and renal sarcoidosis.


Sarcoidosis commonly presents in young adults with bilateral hilar lymphadenopathy, lung parenchymal disease and/or skin lesions. Ocular symptoms are the presenting feature in up to 10% of cases, but eye involvement can be demonstrated in around a quarter of all patients. Renal disease is much rarer, and may manifest with hypercalcaemic nephropathy, granulomatous interstitial nephritis, tubular dysfunction or glomerulonephritis. Eye and renal involvement are rarely found together, and may be confused with Wegener's granulomatosis or polyarteritis. We report a case of a young man who developed renal failure due to sarcoidosis soon after presenting with uveitis. The case illustrates an unusual combination of systemic features that may not be widely recognized.

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  • Siltzbach LE, James DG, Neville E, Turiaf J, Battesti JP, Sharma OP, Hosoda Y, Mikami R, Odaka M. Course and prognosis of sarcoidosis around the world. Am J Med. 1974 Dec;57(6):847–852. [PubMed]
  • Karma A, Huhti E, Poukkula A. Course and outcome of ocular sarcoidosis. Am J Ophthalmol. 1988 Oct 15;106(4):467–472. [PubMed]
  • Rosenbaum JT. Bilateral anterior uveitis and interstitial nephritis. Am J Ophthalmol. 1988 May 15;105(5):534–537. [PubMed]
  • Stavrou P, Deutsch J, Rene C, Laws DE, Luqmani RA, Murray PI. Ocular manifestations of classical and limited Wegener's granulomatosis. Q J Med. 1993 Nov;86(11):719–725. [PubMed]
  • Cook JR, Brubaker RF, Savell J, Sheagren J. Lacrimal sarcoidosis treated with corticosteroids. Arch Ophthalmol. 1972 Nov;88(5):513–517. [PubMed]
  • Sanders MD, Shilling JS. Retinal, choroidal, and optic disc involvement in sarcoidosis. Trans Ophthalmol Soc U K. 1976 Apr;96(1):140–144. [PubMed]
  • Spalton DJ. Fundus changes in sarcoidosis. Review of 33 patients with histological confirmation. Trans Ophthalmol Soc U K. 1979 Apr;99(1):167–169. [PubMed]
  • Lebacq E, Desmet V, Verhaegen H. Renal involvement in sarcoidosis. Postgrad Med J. 1970 Aug;46(538):526–529. [PMC free article] [PubMed]
  • MacSearraigh ET, Doyle CT, Twomey M, O'Sullivan DJ. Sarcoidosis with renal involvement. Postgrad Med J. 1978 Aug;54(634):528–532. [PMC free article] [PubMed]
  • Allegri L, Olivetti G, David S, Concari GM, Dascola G, Savazzi G. Sarcoid granulomatous nephritis with isolated and reversible renal failure. A case report. Nephron. 1980;25(4):207–208. [PubMed]
  • Korzets Z, Schneider M, Taragan R, Bernheim J, Bernheim J. Acute renal failure due to sarcoid granulomatous infiltration of the renal parenchyma. Am J Kidney Dis. 1985 Oct;6(4):250–253. [PubMed]
  • Matsuo N, Yu K, Hasegawa O, Takasugi M, Kuroiwa A, Kajiki A, Miyazaki N, Kido M. [A case of sarcoid granulomatous interstitial nephritis improved by steroid therapy]. Nihon Jinzo Gakkai Shi. 1991 Jul;33(7):703–708. [PubMed]
  • McCurley T, Salter J, Glick A. Renal insufficiency in sarcoidosis. A clinical and pathologic study. Arch Pathol Lab Med. 1990 May;114(5):488–492. [PubMed]
  • Baarsma GS, La Hey E, Glasius E, de Vries J, Kijlstra A. The predictive value of serum angiotensin converting enzyme and lysozyme levels in the diagnosis of ocular sarcoidosis. Am J Ophthalmol. 1987 Sep 15;104(3):211–217. [PubMed]

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