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J R Soc Med. 1995 September; 88(9): 528P–529P.
PMCID: PMC1295336

O'Brien's actinic granuloma: response to isotretinoin.


We describe a 75-year-old man demonstrating the florid clinical features of actinic granuloma of O'Brien. This rare disfiguring condition is believed to result from a granulomatous reaction of the dermis to solar-induced elastosis and is poorly responsive to topical steroids. Twelve weeks' treatment with isotretinoin prevented the development of new granulomata and produced almost complete resolution of established lesions.

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Selected References

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  • O'Brien JP. Actinic granuloma. An annular connective tissue disorder affecting sun- and heat-damaged (elastotic) skin. Arch Dermatol. 1975 Apr;111(4):460–466. [PubMed]
  • Steffen C. Actinic granuloma (O'Brien). J Cutan Pathol. 1988 Apr;15(2):66–74. [PubMed]
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  • Schleicher SM, Milstein HJ, Lim SJ, Stanton CD. Resolution of disseminated granuloma annulare with isotretinoin. Int J Dermatol. 1992 May;31(5):371–372. [PubMed]
  • Griffiths CE, Russman AN, Majmudar G, Singer RS, Hamilton TA, Voorhees JJ. Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid) N Engl J Med. 1993 Aug 19;329(8):530–535. [PubMed]

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