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J R Soc Med. 1995 September; 88(9): 528P–529P.
PMCID: PMC1295336

O'Brien's actinic granuloma: response to isotretinoin.

Abstract

We describe a 75-year-old man demonstrating the florid clinical features of actinic granuloma of O'Brien. This rare disfiguring condition is believed to result from a granulomatous reaction of the dermis to solar-induced elastosis and is poorly responsive to topical steroids. Twelve weeks' treatment with isotretinoin prevented the development of new granulomata and produced almost complete resolution of established lesions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • O'Brien JP. Actinic granuloma. An annular connective tissue disorder affecting sun- and heat-damaged (elastotic) skin. Arch Dermatol. 1975 Apr;111(4):460–466. [PubMed]
  • Steffen C. Actinic granuloma (O'Brien). J Cutan Pathol. 1988 Apr;15(2):66–74. [PubMed]
  • Ragaz A, Ackerman AB. Is actinic granuloma a specific condition? Am J Dermatopathol. 1979 Spring;1(1):43–50. [PubMed]
  • Mehregan AH, Altman J. Miescher's granuloma of the face. A variant of the necrobiosis lipoidica-granuloma annulare spectrum. Arch Dermatol. 1973 Jan;107(1):62–64. [PubMed]
  • Jones EW. Necrobiosis lipoidica presenting on the face and scalp. An account of 29 patients and a detailed consideration of recent histochemical findings. Trans St Johns Hosp Dermatol Soc. 1971;57(1):202–220. [PubMed]
  • Allenby CF, Jones EW. Granuloma multiforme. Trans St Johns Hosp Dermatol Soc. 1969;55(1):88–98. [PubMed]
  • Schleicher SM, Milstein HJ, Lim SJ, Stanton CD. Resolution of disseminated granuloma annulare with isotretinoin. Int J Dermatol. 1992 May;31(5):371–372. [PubMed]
  • Griffiths CE, Russman AN, Majmudar G, Singer RS, Hamilton TA, Voorhees JJ. Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid) N Engl J Med. 1993 Aug 19;329(8):530–535. [PubMed]

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