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J R Soc Med. 1995 May; 88(5): 294P–295P.
PMCID: PMC1295211

Cold urticaria, raised IgE and HIV infection.


We present a patient with cold urticaria as an unusual and late cutaneous manifestation of acquired immunodeficiency syndrome. The severe CD4 cell depletion and markedly elevated serum IgE levels in our patient provide some insights into certain aspects of immune regulatory mechanisms.

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Selected References

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  • Lawlor F, Kobza Black A, Breathnach AS, McKee P, Sarathchandra P, Bhogal B, Isaacs JL, Greaves MW, Winkelmann RK. A timed study of the histopathology, direct immunofluorescence and ultrastructural findings in idiopathic cold-contact urticaria over a 24-h period. Clin Exp Dermatol. 1989 Nov;14(6):416–420. [PubMed]
  • Lin RY, Schwartz RA. Cold urticaria and HIV infection. Br J Dermatol. 1993 Oct;129(4):465–467. [PubMed]
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  • Rossol S, Voth R, Laubenstein HP, Müller WE, Schröder HC, Meyer zum Büschenfelde KH, Hess G. Interferon production in patients infected with HIV-1. J Infect Dis. 1989 May;159(5):815–821. [PubMed]
  • Romagnani S, Del Prete G, Maggi E, Parronchi P, Tiri A, Macchia D, Giudizi MG, Almerigogna F, Ricci M. Role of interleukins in induction and regulation of human IgE synthesis. Clin Immunol Immunopathol. 1989 Jan;50(1 Pt 2):S13–S23. [PubMed]

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