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J R Soc Med. 1995 March; 88(3): 174P–175P.
PMCID: PMC1295145

Cushing's syndrome: still a potential killing disease.


When Harvey Cushing described his syndrome in 1932 he named it the killing disease because of its cardiovascular complications. Heart failure is rarely reported as a presenting feature. We report a case in which left ventricular failure (LVF) was the predominant feature, associated with gross left ventricular hypertrophy (LVH) which regressed after treatment.

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Selected References

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  • PLOTZ CM, KNOWLTON AI, RAGAN C. The natural history of Cushing's syndrome. Am J Med. 1952 Nov;13(5):597–614. [PubMed]
  • Welbourn RB, Montgomery DA, Kennedy TL. The natural history of treated Cushing's syndrome. Br J Surg. 1971 Jan;58(1):1–16. [PubMed]
  • Ross EJ, Linch DC. Cushing's syndrome--killing disease: discriminatory value of signs and symptoms aiding early diagnosis. Lancet. 1982 Sep 18;2(8299):646–649. [PubMed]
  • Sugihara N, Shimizu M, Kita Y, Shimizu K, Ino H, Miyamori I, Nakabayashi H, Takeda R. Cardiac characteristics and postoperative courses in Cushing's syndrome. Am J Cardiol. 1992 Jun 1;69(17):1475–1480. [PubMed]
  • White WB, Schulman P, Karimeddini MK, Smith VE. Regression of left ventricular mass is accompanied by improvement in rapid left ventricular filling following antihypertensive therapy with metoprolol. Am Heart J. 1989 Jan;117(1):145–150. [PubMed]
  • Asmar RG, Pannier B, Santoni JP, Laurent S, London GM, Levy BI, Safar ME. Reversion of cardiac hypertrophy and reduced arterial compliance after converting enzyme inhibition in essential hypertension. Circulation. 1988 Oct;78(4):941–950. [PubMed]
  • Saruta T, Suzuki H, Handa M, Igarashi Y, Kondo K, Senba S. Multiple factors contribute to the pathogenesis of hypertension in Cushing's syndrome. J Clin Endocrinol Metab. 1986 Feb;62(2):275–279. [PubMed]

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