Search tips
Search criteria 


Logo of jrsocmedLink to Publisher's site
J R Soc Med. 1995 March; 88(3): 161P–165P.
PMCID: PMC1295141

Screening tests for growth hormone deficiency.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (774K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bercu BB, Shulman D, Root AW, Spiliotis BE. Growth hormone (GH) provocative testing frequently does not reflect endogenous GH secretion. J Clin Endocrinol Metab. 1986 Sep;63(3):709–716. [PubMed]
  • Spiliotis BE, August GP, Hung W, Sonis W, Mendelson W, Bercu BB. Growth hormone neurosecretory dysfunction. A treatable cause of short stature. JAMA. 1984 May 4;251(17):2223–2230. [PubMed]
  • Zadik Z, Chalew SA, Gilula Z, Kowarski AA. Reproducibility of growth hormone testing procedures: a comparison between 24-hour integrated concentration and pharmacological stimulation. J Clin Endocrinol Metab. 1990 Nov;71(5):1127–1130. [PubMed]
  • Rose SR, Ross JL, Uriarte M, Barnes KM, Cassorla FG, Cutler GB., Jr The advantage of measuring stimulated as compared with spontaneous growth hormone levels in the diagnosis of growth hormone deficiency. N Engl J Med. 1988 Jul 28;319(4):201–207. [PubMed]
  • Lacey KA, Hewison A, Parkin JM. Exercise as a screening test for growth hormone deficiency in children. Arch Dis Child. 1973 Jul;48(7):508–512. [PMC free article] [PubMed]
  • Nicoll AG, Smail PJ, Forsyth CC. Exercise test for growth hormone deficiency. Arch Dis Child. 1984 Dec;59(12):1177–1178. [PMC free article] [PubMed]
  • Mace JW, Gotlin RW, Beck P. Sleep related human growth hormone (GH) release: a test of physiologic growth hormone secretion in children. J Clin Endocrinol Metab. 1972 Feb;34(2):339–341. [PubMed]
  • King JM, Price DA. Sleep-induced growth hormone release--evaluation of a simple test for clinical use. Arch Dis Child. 1983 Mar;58(3):220–222. [PMC free article] [PubMed]
  • Hindmarsh PC, Smith PJ, Taylor BJ, Pringle PJ, Brook CG. Comparison between a physiological and a pharmacological stimulus of growth hormone secretion: response to stage IV sleep and insulin-induced hypoglycaemia. Lancet. 1985 Nov 9;2(8463):1033–1035. [PubMed]
  • Girard J, Erb T, Pampalone A, Eberle AN, Baumann JB. Growth hormone in urine: development of an ultrasensitive assay applicable to plasma and urine. Horm Res. 1987;28(1):71–80. [PubMed]
  • Albini CH, Sotos J, Sherman B, Johanson A, Celniker A, Hopwood N, Quattrin T, Mills BJ, MacGillivray MH. Diagnostic significance of urinary growth hormone measurements in children with growth failure: correlation between serum and urine growth hormone. Pediatr Res. 1991 Jun;29(6):619–622. [PubMed]
  • Edge JA, Hourd P, Edwards R, Dunger DB. Urinary growth hormone during puberty in normal and diabetic children. Clin Endocrinol (Oxf) 1989 Apr;30(4):413–420. [PubMed]
  • Okuno A, Yano K, Itoh Y, Hashida S, Ishikawa E, Mohri Z, Murakami Y. Urine growth hormone determinations compared with other methods in the assessment of growth hormone secretion. Acta Paediatr Scand Suppl. 1987;337:74–81. [PubMed]
  • Sukegawa I, Hizuka N, Takano K, Asakawa K, Horikawa R, Hashida S, Ishikawa E, Mohri Z, Murakami Y, Shizume K. Measurement of nocturnal urinary growth hormone values. Acta Endocrinol (Copenh) 1989 Aug;121(2):290–296. [PubMed]
  • Evans AJ, Wood PJ. Development of an assay for human growth hormone in urine using commercially available reagents. Ann Clin Biochem. 1989 Jul;26(Pt 4):353–357. [PubMed]
  • Hourd P, Edwards R. Measurement of human growth hormone in urine: development and validation of a sensitive and specific assay. J Endocrinol. 1989 Apr;121(1):167–175. [PubMed]
  • Hashida S, Ishikawa E, Kato Y, Imura H, Mohri Z, Murakami Y. Human growth hormone (hGH) in urine and its correlation to serum hGH examined by a highly sensitive sandwich enzyme immunoassay. Clin Chim Acta. 1987 Jan 30;162(2):229–235. [PubMed]
  • Girard J, Fischer-Wasels T. Measurement of urinary growth hormone. A noninvasive method to assess the 'growth hormone status'. Horm Res. 1990;33 (Suppl 4):12–18. [PubMed]
  • Evans AJ, Willis DS, Wood PJ. The assay of urinary growth hormone in normal and acromegalic adults. Clin Endocrinol (Oxf) 1991 Nov;35(5):413–418. [PubMed]
  • Walker JM, Wood PJ, Williamson S, Betts PR, Evans AJ. Urinary growth hormone excretion as a screening test for growth hormone deficiency. Arch Dis Child. 1990 Jan;65(1):89–92. [PMC free article] [PubMed]
  • Tomita H, Ogawa M, Kamijo T, Mori O, Ishikawa E, Mohri Z, Murakami Y. A highly sensitive sandwich enzyme immunoassay of urinary growth hormone in children with short stature, Turner's syndrome, and simple obesity. Acta Endocrinol (Copenh) 1989 Oct;121(4):513–519. [PubMed]
  • Crowne EC, Wallace WH, Shalet SM, Addison GM, Price DA. Relationship between urinary and serum growth hormone and pubertal status. Arch Dis Child. 1992 Jan;67(1):91–95. [PMC free article] [PubMed]
  • Price DA, Addison GM, Herbert ED. Increase in urinary growth hormone excretion in puberty. Arch Dis Child. 1990 Nov;65(11):1203–1204. [PMC free article] [PubMed]
  • Pan FP, Stevenson JL, Donaldson DL, Levy J, Wiegmann T, Moore WV. Correlation of urinary albumin and beta-2-microglobulin and growth hormone excretion in patients with diabetes mellitus and short stature. J Clin Endocrinol Metab. 1990 Sep;71(3):611–617. [PubMed]
  • Hattori N, Kato Y, Murakami Y, Hashida S, Ishikawa E, Mohri Z, Imura H. Urinary growth hormone levels measured by ultrasensitive enzyme immunoassay in patients with renal insufficiency. J Clin Endocrinol Metab. 1988 Apr;66(4):727–732. [PubMed]
  • Tassoni P, Cacciari E, Cau M, Colli C, Tosi M, Zucchini S, Cicognani A, Pirazzoli P, Salardi S, Balsamo A, et al. Variability of growth hormone response to pharmacological and sleep tests performed twice in short children. J Clin Endocrinol Metab. 1990 Jul;71(1):230–234. [PubMed]
  • Hoehe M, Valido G, Matussek N. Growth hormone, noradrenaline, blood pressure and cortisol responses to clonidine in healthy male volunteers: dose-response relations and reproducibility. Psychoneuroendocrinology. 1988;13(5):409–418. [PubMed]
  • Laron Z, Klinger B, Erster B, Silbergeld A. Serum GH binding protein activities identifies the heterozygous carriers for Laron type dwarfism. Acta Endocrinol (Copenh) 1989 Oct;121(4):603–608. [PubMed]
  • Merimee TJ, Baumann G, Daughaday W. Growth hormone-binding protein: II. Studies in pygmies and normal statured subjects. J Clin Endocrinol Metab. 1990 Nov;71(5):1183–1188. [PubMed]
  • Rudman D, Kutner MH, Chawla RK. The short child with subnormal plasma somatomedin C. Pediatr Res. 1985 Oct;19(10):975–980. [PubMed]
  • Rosenfeld RG, Wilson DM, Lee PD, Hintz RL. Insulin-like growth factors I and II in evaluation of growth retardation. J Pediatr. 1986 Sep;109(3):428–433. [PubMed]
  • Dean HJ, Kellett JG, Bala RM, Guyda HJ, Bhaumick B, Posner BI, Friesen HG. The effect of growth hormone treatment on somatomedin levels in growth hormone-deficient children. J Clin Endocrinol Metab. 1982 Dec;55(6):1167–1173. [PubMed]
  • Luna AM, Wilson DM, Wibbelsman CJ, Brown RC, Nagashima RJ, Hintz RL, Rosenfeld RG. Somatomedins in adolescence: a cross-sectional study of the effect of puberty on plasma insulin-like growth factor I and II levels. J Clin Endocrinol Metab. 1983 Aug;57(2):268–271. [PubMed]
  • Moore DC, Ruvalcaba RH, Smith EK, Kelley VC. Plasma somatomedin-C as a screening test for growth hormone deficiency in children and adolescents. Horm Res. 1982;16(1):49–55. [PubMed]
  • Ranke MB, Blum WF, Bierich JR. Clinical relevance of serum measurements of insulin-like growth factors and somatomedin binding proteins. Acta Paediatr Scand Suppl. 1988;347:114–126. [PubMed]
  • Park MS, Kim DH. Diagnostic value of insulin-like growth factor-I in short stature. Yonsei Med J. 1989 Dec;30(4):367–375. [PubMed]
  • Isley WL, Underwood LE, Clemmons DR. Dietary components that regulate serum somatomedin-C concentrations in humans. J Clin Invest. 1983 Feb;71(2):175–182. [PMC free article] [PubMed]
  • Merimee TJ, Zapf J, Froesch ER. Insulin-like growth factors in the fed and fasted states. J Clin Endocrinol Metab. 1982 Nov;55(5):999–1002. [PubMed]
  • Blum WF, Ranke MB. Use of insulin-like growth factor-binding protein 3 for the evaluation of growth disorders. Horm Res. 1990;33 (Suppl 4):31–37. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press