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J R Soc Med. 1995 March; 88(3): 130–135.
PMCID: PMC1295130

Prospective study of the quality of life in patients assessed for liver transplantation: outcome in transplanted and not transplanted groups.


The quality of life in adult patients with chronic liver disease who were considered for transplantation was assessed prospectively over a 2 year period, for both those who did and did not subsequently receive transplants. The main outcome measures were the Nottingham Health Profile and survival. Of the 109 patients who completed an entry profile, 27 were transplanted, 71 not transplanted during the study period, and 11 rejected for transplant. Quality of life and severity of liver disease at entry was worse for the transplant group, whose survival at 15 months from entry was 81% compared with 78% for those not transplanted. Among transplant survivors there were marked improvements in quality of life, whilst amongst those not receiving transplants there was little change. In conclusion, liver transplantation was effective in improving quality of life in patients with chronic liver disease, but comparison between transplant and non-transplant patients is difficult because of differences between the groups.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Starzl TE, Demetris AJ, Van Thiel D. Liver transplantation (2). N Engl J Med. 1989 Oct 19;321(16):1092–1099. [PubMed]
  • Bonsel GJ, Klompmaker IJ, Essink-Bot ML, Habbema JD, Slooff MJ. Cost-effectiveness analysis of the Dutch liver transplantation programme. Transplant Proc. 1990 Aug;22(4):1481–1484. [PubMed]
  • Tarter RE, Erb S, Biller PA, Switala J, Van Thiel DH. The quality of life following liver transplantation: a preliminary report. Gastroenterol Clin North Am. 1988 Mar;17(1):207–217. [PubMed]
  • Pennington JC., Jr Quality of life following liver transplantation. Transplant Proc. 1989 Jun;21(3):3514–3516. [PubMed]
  • O'Brien BJ, Banner NR, Gibson S, Yacoub MH. The Nottingham Health Profile as a measure of quality of life following combined heart and lung transplantation. J Epidemiol Community Health. 1988 Sep;42(3):232–234. [PMC free article] [PubMed]
  • Lowe D, O'Grady JG, McEwen J, Williams R. Quality of life following liver transplantation: a preliminary report. J R Coll Physicians Lond. 1990 Jan;24(1):43–46. [PubMed]

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