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J R Soc Med. 1995 February; 88(2): 108P–109P.
PMCID: PMC1295111

Semen contact urticaria.


An allergic reaction to human seminal fluid was first reported by Halpern et al. 1967. Since then there have been more than 30 cases recorded in the literature but it remains a rare cause of dyspareunia.

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Selected References

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  • Halpern BN, Ky T, Robert B. Clinical and immunological study of an exceptional case of reaginic type sensitization to human seminal fluid. Immunology. 1967 Mar;12(3):247–258. [PubMed]
  • Jones WR. Allergy to coitus. Aust N Z J Obstet Gynaecol. 1991 May;31(2):137–141. [PubMed]
  • Mathias CG, Frick OL, Caldwell TM, Yunginger JW, Maibach HI. Immediate hypersensitivity to seminal fluid and atopic dermatitis. Arch Dermatol. 1980 Feb;116(2):209–212. [PubMed]
  • Presti ME, Druce HM. Hypersensitivity reactions to human seminal plasma. Ann Allergy. 1989 Dec;63(6 Pt 1):477–481. [PubMed]
  • Schulz KH, Schirren C, Kueppers F. Letter: Allergy to seminal fluid. N Engl J Med. 1974 Apr 18;290(16):916–916. [PubMed]
  • Holden TE, Sherline DM. Bestiality, with sensitization and anaphylactic reaction. Obstet Gynecol. 1973 Jul;42(1):138–140. [PubMed]
  • Boom BW, van Toorenenbergen AW, Nierop G, van der Schroeff JG. A case of seminal fluid allergy successfully treated with immunotherapy in a one-day rush procedure. J Dermatol. 1991 Apr;18(4):206–210. [PubMed]
  • Mikkelsen EJ, Henderson LL, Leiferman KM, Gleich GJ. Allergy to human seminal fluid. Ann Allergy. 1975 Apr;34(4):239–243. [PubMed]
  • Bosso JV, Aiken MJ, Simon RA. Successful prevention of local and cutaneous hypersensitivity reactions to seminal fluid with intravaginal cromolyn. Allergy Proc. 1991 Mar-Apr;12(2):113–116. [PubMed]
  • Matloff SM. Local intravaginal desensitization to seminal fluid. J Allergy Clin Immunol. 1993 Jun;91(6):1230–1231. [PubMed]

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