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J R Soc Med. 1995 February; 88(2): 105P–107P.
PMCID: PMC1295110

Induction of labour using prostaglandin E2 gel: the effect of changing the time of first insertion.


This study forms part of an on-going audit into induction of labour using prostaglandin E2 vaginal gel at a district general hospital. It looks at the effect of changing the time of first insertion of the gel from 2200 h to 1400 h in 80 primiparous women between 37 and 42 completed weeks' gestation, booked for induction of labour. Significant reductions in total cost of admission and length of hospital stay were associated with induction at 1400 h, and a trend to shorter time from induction to rupture of membranes and lower Caesarean section rate was also noted. Larger studies are needed.

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Selected References

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  • Shepherd J, Pearce JM, Sims CD. Induction of labour using prostaglandin E2 pessaries. Br Med J. 1979 Jul 14;2(6182):108–110. [PMC free article] [PubMed]
  • Greer IA, McLaren M, Calder AA. Vaginal administration of PGE2 for induction of labor stimulates endogenous PGF2 alpha production. Acta Obstet Gynecol Scand. 1990;69(7-8):621–625. [PubMed]
  • Mahmood TA. A prospective comparative study on the use of prostaglandin E2 gel (2 mg) and prostaglandin E2 tablet (3 mg) for the induction of labour in primigravid women with unfavorable cervices. Eur J Obstet Gynecol Reprod Biol. 1989 Nov;33(2):169–175. [PubMed]

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