Search tips
Search criteria 


Logo of jrsocmedLink to Publisher's site
J R Soc Med. 1995 February; 88(2): 63–66.
PMCID: PMC1295096

Gut permeability measured by polyethylene glycol absorption in abnormal gut fermentation as compared with food intolerance.


Gut permeability has been studied in patients with either food intolerance or abnormal gut fermentation as well as in normal subjects. Permeability was measured by polyethylene glycol absorption, and the reasons for this choice of probe are discussed. Results show that both symptomatic groups have statistically very highly significant deviations from the normal (P < 0.01), consisting of over-adsorption, significant at molecular weights 242, 286, 330 and 374. Whilst both study groups were different from the normal they were not different from each other. The implications for these findings in the diagnosis and management of food intolerance and abnormal gut fermentation are discussed.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (693K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Eaton KK. Gut fermentation: a reappraisal of an old clinical condition with diagnostic tests and management: discussion paper. J R Soc Med. 1991 Nov;84(11):669–671. [PMC free article] [PubMed]
  • Egger J, Carter CM, Wilson J, Turner MW, Soothill JF. Is migraine food allergy? A double-blind controlled trial of oligoantigenic diet treatment. Lancet. 1983 Oct 15;2(8355):865–869. [PubMed]
  • Douglas NJ, Calverley PM, Leggett RJ, Brash HM, Flenley DC, Brezinova V. Transient hypoxaemia during sleep in chronic bronchitis and emphysema. Lancet. 1979 Jan 6;1(8106):1–4. [PubMed]
  • Haeney MR, Culank LS, Montgomery RD, Sammons HG. Evaluation of xylose absorption as measured in blood and urine: a one-hour blood xylose screening test in malabsorption. Gastroenterology. 1978 Sep;75(3):393–400. [PubMed]
  • Chadwick VS, Phillips SF, Hofmann AF. Measurements of intestinal permeability using low molecular weight polyethylene glycols (PEG 400). I. Chemical analysis and biological properties of PEG 400. Gastroenterology. 1977 Aug;73(2):241–246. [PubMed]
  • Chadwick VS, Phillips SF, Hofmann AF. Measurements of intestinal permeability using low molecular weight polyethylene glycols (PEG 400). II. Application to normal and abnormal permeability states in man and animals. Gastroenterology. 1977 Aug;73(2):247–251. [PubMed]
  • MacKie RM. Intestinal permeability and atopic disease. Lancet. 1981 Jul 18;2(8238):155–155. [PubMed]
  • Sagnella GA, Markandu ND, Shore AC, MacGregor GA. Raised circulating levels of atrial natriuretic peptides in essential hypertension. Lancet. 1986 Jan 25;1(8474):179–181. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press