PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jrsocmedLink to Publisher's site
 
J R Soc Med. 1994 October; 87(10): 608–609.
PMCID: PMC1294853

Glucose tolerance and ageing.

Abstract

Hyperglycaemia, impaired glucose tolerance and noninsulin dependent diabetes become progressively more common with advancing age. The mechanism is insensitivity to the actions of insulin at the postreceptor level. Inadequate secretion of insulin and decreased hepatic sensitivity to insulin's action in suppressing glucose output also occur. The age-related changes may be made worse by obesity, renal failure or the ingestion of certain drugs, or may be lessened by increased physical activity.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (445K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.
 
 

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Laakso M, Pyörälä K. Age of onset and type of diabetes. Diabetes Care. 1985 Mar-Apr;8(2):114–117. [PubMed]
  • Neil HA, Thompson AV, Thorogood M, Fowler GH, Mann JI. Diabetes in the elderly: the Oxford Community Diabetes Study. Diabet Med. 1989 Sep-Oct;6(7):608–613. [PubMed]
  • Harris MI, Hadden WC, Knowler WC, Bennett PH. Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in U.S. population aged 20-74 yr. Diabetes. 1987 Apr;36(4):523–534. [PubMed]
  • Stengård JH, Pekkanen J, Tuomilehto J, Kivinen P, Kaarsalo E, Tamminen M, Nissinen A, Karvonen MJ. Changes in glucose tolerance among elderly Finnish men during a five-year follow-up: the Finnish cohorts of the Seven Countries Study. Diabete Metab. 1993;19(1 Pt 2):121–129. [PubMed]
  • Gale EA, Dornan TL, Tattersall RB. Severely uncontrolled diabetes in the over-fifties. Diabetologia. 1981 Jul;21(1):25–28. [PubMed]
  • McConnell JG, Buchanan KD, Ardill J, Stout RW. Glucose tolerance in the elderly: the role of insulin and its receptor. Eur J Clin Invest. 1982 Feb;12(1):55–61. [PubMed]
  • Fink RI, Kolterman OG, Griffin J, Olefsky JM. Mechanisms of insulin resistance in aging. J Clin Invest. 1983 Jun;71(6):1523–1535. [PMC free article] [PubMed]
  • Rowe JW, Minaker KL, Pallotta JA, Flier JS. Characterization of the insulin resistance of aging. J Clin Invest. 1983 Jun;71(6):1581–1587. [PMC free article] [PubMed]
  • Minaker KL, Rowe JW, Tonino R, Pallotta JA. Influence of age on clearance of insulin in man. Diabetes. 1982 Oct;31(10):851–855. [PubMed]
  • Paolisso G, D'Amore A, Di Maro G, Galzerano D, Tesauro P, Varricchio M, D'Onofrio F. Evidence for a relationship between free radicals and insulin action in the elderly. Metabolism. 1993 May;42(5):659–663. [PubMed]
  • Chen M, Bergman RN, Pacini G, Porte D., Jr Pathogenesis of age-related glucose intolerance in man: insulin resistance and decreased beta-cell function. J Clin Endocrinol Metab. 1985 Jan;60(1):13–20. [PubMed]
  • Jackson RA, Blix PM, Matthews JA, Hamling JB, Din BM, Brown DC, Belin J, Rubenstein AH, Nabarro JD. Influence of ageing on glucose homeostasis. J Clin Endocrinol Metab. 1982 Nov;55(5):840–848. [PubMed]
  • McConnell JG, Alam MJ, O'Hare MM, Buchanan KD, Stout RW. The effect of age and sex on the response of enteropancreatic polypeptides to oral glucose. Age Ageing. 1983 Feb;12(1):54–62. [PubMed]
  • Cameron CM, Kostyo JL. Influence of age on responsiveness to diabetogenic action of growth hormone. Diabetes. 1987 Jan;36(1):88–92. [PubMed]
  • Chen M, Halter JB, Porte D., Jr Plasma catecholamines, dietary carbohydrate, and glucose intolerance: a comparison between young and old men. J Clin Endocrinol Metab. 1986 Jun;62(6):1193–1198. [PubMed]
  • Kohrt WM, Kirwan JP, Staten MA, Bourey RE, King DS, Holloszy JO. Insulin resistance in aging is related to abdominal obesity. Diabetes. 1993 Feb;42(2):273–281. [PubMed]
  • Dallosso HM, Morgan K, Bassey EJ, Ebrahim SB, Fentem PH, Arie TH. Levels of customary physical activity among the old and the very old living at home. J Epidemiol Community Health. 1988 Jun;42(2):121–127. [PMC free article] [PubMed]
  • Seals DR, Hagberg JM, Allen WK, Hurley BF, Dalsky GP, Ehsani AA, Holloszy JO. Glucose tolerance in young and older athletes and sedentary men. J Appl Physiol Respir Environ Exerc Physiol. 1984 Jun;56(6):1521–1525. [PubMed]
  • Coon PJ, Bleecker ER, Drinkwater DT, Meyers DA, Goldberg AP. Effects of body composition and exercise capacity on glucose tolerance, insulin, and lipoprotein lipids in healthy older men: a cross-sectional and longitudinal intervention study. Metabolism. 1989 Dec;38(12):1201–1209. [PubMed]
  • Pollare T, Lithell H, Berne C. A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension. N Engl J Med. 1989 Sep 28;321(13):868–873. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press