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J R Soc Med. 1994 August; 87(8): 445–447.
PMCID: PMC1294682

Psychiatric morbidity in adults with hypopituitarism.


Forty-one adults with established hypopituitarism and deficiency of growth hormone (GHD) were compared to an age and sex-matched group with another chronic metabolic disorder (diabetes mellitus) using standardized psychiatric rating and diagnostic measures. Nineteen (46%) of the GHD group were identified as definite psychiatric cases compared with 10 (24%) of the diabetics (odds ratio 1:9:1). The most frequent DSM III-R axis I psychiatric diagnoses were major depression (32% GHD patients and 10% of diabetic patients) and dysthymia. The risk of being a psychiatric case showed an association with duration of illness in the diabetic group, but not in the GHD group. Biochemical indices were not related to the risk of being a case in either group. Hypopituitarism is associated with a higher prevalence of psychiatric disturbance than can be attributed solely to the presence of a chronic disorder.

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Selected References

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  • Säf M, Thorén M, Bergstrand CG, Norén G, Rähn T, Tallstedt L, Backlund EO. Treatment of craniopharyngiomas--the stereotactic approach in a ten to twenty-three years' perspective. II. Psychosocial situation and pituitary function. Acta Neurochir (Wien) 1989;99(3-4):97–103. [PubMed]
  • Rotnem D, Cohen DJ, Hintz R, Genel M. Psychological sequelae of relative "treatment failure" for children receiving human growth hormone replacement. J Am Acad Child Psychiatry. 1979 Summer;18(3):505–520. [PubMed]
  • Dean HJ, McTaggart TL, Fish DG, Friesen HG. The educational, vocational, and marital status of growth hormone-deficient adults treated with growth hormone during childhood. Am J Dis Child. 1985 Nov;139(11):1105–1110. [PubMed]
  • Almqvist O, Thorén M, Säf M, Eriksson O. Effects of growth hormone substitution on mental performance in adults with growth hormone deficiency: a pilot study. Psychoneuroendocrinology. 1986;11(3):347–352. [PubMed]
  • McGauley GA, Cuneo RC, Salomon F, Sönksen PH. Psychological well-being before and after growth hormone treatment in adults with growth hormone deficiency. Horm Res. 1990;33 (Suppl 4):52–54. [PubMed]
  • Wilkinson G, Borsey DQ, Leslie P, Newton RW, Lind C, Ballinger CB. Psychiatric morbidity and social problems in patients with insulin-dependent diabetes mellitus. Br J Psychiatry. 1988 Jul;153:38–43. [PubMed]
  • Goldberg DP, Cooper B, Eastwood MR, Kedward HB, Shepherd M. A standardized psychiatric interview for use in community surveys. Br J Prev Soc Med. 1970 Feb;24(1):18–23. [PMC free article] [PubMed]
  • Tyrer P, Owen RT, Cicchetti DV. The brief scale for anxiety: a subdivision of the comprehensive psychopathological rating scale. J Neurol Neurosurg Psychiatry. 1984 Sep;47(9):970–975. [PMC free article] [PubMed]
  • Thorén P, Asberg M, Cronholm B, Jörnestedt L, Träskman L. Clomipramine treatment of obsessive-compulsive disorder. I. A controlled clinical trial. Arch Gen Psychiatry. 1980 Nov;37(11):1281–1285. [PubMed]
  • Katona CL, Theodorou AE, Horton RW. Alpha 2-adrenoceptors in depression. Psychiatr Dev. 1987 Summer;5(2):129–149. [PubMed]
  • Dinan TG, Barry S. Responses of growth hormone to desipramine in endogenous and non-endogenous depression. Br J Psychiatry. 1990 May;156:680–684. [PubMed]
  • Mitchell PB, Bearn JA, Corn TH, Checkley SA. Growth hormone response to clonidine after recovery in patients with endogenous depression. Br J Psychiatry. 1988 Jan;152:34–38. [PubMed]
  • Lesch KP, Laux G, Erb A, Pfüller H, Beckmann H. Attenuated growth hormone response to growth hormone-releasing hormone in major depressive disorder. Biol Psychiatry. 1987 Dec;22(12):1495–1499. [PubMed]
  • Jarrett DB, Miewald JM, Kupfer DJ. Recurrent depression is associated with a persistent reduction in sleep-related growth hormone secretion. Arch Gen Psychiatry. 1990 Feb;47(2):113–118. [PubMed]

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