PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jrsocmedLink to Publisher's site
 
J R Soc Med. 1994 June; 87(6): 323–326.
PMCID: PMC1294559

Biopsy proven polymyositis in Victoria 1982-1987: analysis of prognostic factors.

Abstract

Prognostic factors were analysed in 77 patients with idiopathic inflammatory myopathy identified over a 5 year period. Formal statistical tests did not differentiate useful prognostic indices and a polymyositis disability score was devised in an attempt to gain some prognostic information. Partial (47%) or full (31%) recovery were seen in most cases with no recovery of strength (9%) and death (11%) being less common outcomes. Onset before the age of 50 and duration of symptoms of less than 12 months prior to presentation were favourable prognostic features, and treatment with regimes other than steroid therapy alone a probable favourable indicator. Level of creatine kinase (CK) at presentation and histopathological separation of dermatomyositis or polymyositis failed to alter prognosis. Most patients who died did so within the initial 6 months of treatment. Four of five patients < 50 years old with either a fatal outcome or no improvement were treated with steroids alone. Large multi-centre studies are required to provide reliable data about prognostic factors in idiopathic inflammatory myopathies and the methodology used in this study can only be regarded as providing pointers towards possible prognostic factors rather than being definitive.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (878K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Carpenter JR, Bunch TW, Engel AG, O'Brien PC. Survival in polymyositis: corticosteroids and risk factors. J Rheumatol. 1977 Summer;4(2):207–214. [PubMed]
  • Benbassat J, Gefel D, Larholt K, Sukenik S, Morgenstern V, Zlotnick A. Prognostic factors in polymyositis/dermatomyositis. A computer-assisted analysis of ninety-two cases. Arthritis Rheum. 1985 Mar;28(3):249–255. [PubMed]
  • Hochberg MC, Feldman D, Stevens MB. Adult onset polymyositis/dermatomyositis: an analysis of clinical and laboratory features and survival in 76 patients with a review of the literature. Semin Arthritis Rheum. 1986 Feb;15(3):168–178. [PubMed]
  • Ogle S. Retrospective study of polymyositis in Auckland over 10 years. N Z Med J. 1980 Dec 10;92(673):433–435. [PubMed]
  • Henriksson KG, Sandstedt P. Polymyositis--treatment and prognosis. A study of 107 patients. Acta Neurol Scand. 1982 Apr;65(4):280–300. [PubMed]
  • Tymms KE, Webb J. Dermatopolymyositis and other connective tissue diseases: a review of 105 cases. J Rheumatol. 1985 Dec;12(6):1140–1148. [PubMed]
  • Hoffman GS, Franck WA, Raddatz DA, Stallones L. Presentation, treatment, and prognosis of idiopathic inflammatory muscle disease in a rural hospital. Am J Med. 1983 Sep;75(3):433–438. [PubMed]
  • Bohan A, Peter JB, Bowman RL, Pearson CM. Computer-assisted analysis of 153 patients with polymyositis and dermatomyositis. Medicine (Baltimore) 1977 Jul;56(4):255–286. [PubMed]
  • Edwards RH, Wiles CM, Round JM, Jackson MJ, Young A. Muscle breakdown and repair in polymyositis: a case study. Muscle Nerve. 1979 May-Jun;2(3):223–228. [PubMed]
  • Granit R. The functional role of the muscle spindles--facts and hypotheses. Brain. 1975 Dec;98(4):531–556. [PubMed]
  • Henriksson KG. Recent advances in investigation of polymyositis. Acta Neurol Scand Suppl. 1980;78:60–67. [PubMed]
  • Callen JP, Hyla JF, Bole GG, Jr, Kay DR. The relationship of dermatomyositis and polymyositis to internal malignancy. Arch Dermatol. 1980 Mar;116(3):295–298. [PubMed]
  • Coleman RA, Stajich JM, Pact VW, Pericak-Vance MA. The ischemic exercise test in normal adults and in patients with weakness and cramps. Muscle Nerve. 1986 Mar-Apr;9(3):216–221. [PubMed]
  • Barnes BE, Mawr B. Dermatomyositis and malignancy. A review of the literature. Ann Intern Med. 1976 Jan;84(1):68–76. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press