Search tips
Search criteria 


Logo of jrsocmedLink to Publisher's site
J R Soc Med. 1994 April; 87(4): 203–205.
PMCID: PMC1294441

Cytomegalovirus colitis in patients with acquired immunodeficiency syndrome.


The spectrum of presentation of complications in patients with human immunodeficiency virus (HIV) disease is changing, in line with their improved survival. Infection of the colon with cytomegalovirus (CMV) is now more commonly encountered in clinical practice. We have reviewed the medical records of eleven patients with clinical and pathological evidence of CMV colitis. The clinical presentation, endoscopic and histological findings, and simultaneous infection of other organs with CMV are discussed. Diarrhoea in association with abdominal pain is the most frequent symptom complex in these patients and should raise the clinical index of suspicion for CMV colitis.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (945K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Moore RD, Hidalgo J, Sugland BW, Chaisson RE. Zidovudine and the natural history of the acquired immunodeficiency syndrome. N Engl J Med. 1991 May 16;324(20):1412–1416. [PubMed]
  • Rene E, Marche C, Chevalier T, Rouzioux C, Regnier B, Saimot AG, Negesse Y, Matheron S, Leport C, Wolff B, et al. Cytomegalovirus colitis in patients with acquired immunodeficiency syndrome. Dig Dis Sci. 1988 Jun;33(6):741–750. [PubMed]
  • Jacobson MA, Mills J. Serious cytomegalovirus disease in the acquired immunodeficiency syndrome (AIDS). Clinical findings, diagnosis, and treatment. Ann Intern Med. 1988 Apr;108(4):585–594. [PubMed]
  • Chachoua A, Dieterich D, Krasinski K, Greene J, Laubenstein L, Wernz J, Buhles W, Koretz S. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine (ganciclovir) in the treatment of cytomegalovirus gastrointestinal disease with the acquired immunodeficiency syndrome. Ann Intern Med. 1987 Aug;107(2):133–137. [PubMed]
  • Doskocil M, Med M, Vimmer T. Musculus rectus femoris--zacátecní slacha, její funkcní význam. Acta Chir Orthop Traumatol Cech. 1987 Apr;54(2):99–107. [PubMed]
  • Laskin OL, Stahl-Bayliss CM, Kalman CM, Rosecan LR. Use of ganciclovir to treat serious cytomegalovirus infections in patients with AIDS. J Infect Dis. 1987 Feb;155(2):323–327. [PubMed]
  • Meiselman MS, Cello JP, Margaretten W. Cytomegalovirus colitis. Report of the clinical, endoscopic, and pathologic findings in two patients with the acquired immune deficiency syndrome. Gastroenterology. 1985 Jan;88(1 Pt 1):171–175. [PubMed]
  • Lepinski SM, Hamilton JW. Isolated cytomegalovirus ileitis detected by colonoscopy. Gastroenterology. 1990 Jun;98(6):1704–1706. [PubMed]
  • Guttman D, Raymond A, Gelb A, Ehya H, Mather U, Mildvan D, Spigland I. Virus-associated colitis in homosexual men: two case reports. Am J Gastroenterol. 1983 Mar;78(3):167–169. [PubMed]
  • Orloff JJ, Saito R, Lasky S, Dave H. Toxic megacolon in cytomegalovirus colitis. Am J Gastroenterol. 1989 Jul;84(7):794–797. [PubMed]
  • O'Donnell JJ, Jacobson MA, Mills J. Development of cytomegalovirus (CMV) retinitis in a patient with AIDS during ganciclovir therapy of CMV colitis. N Engl J Med. 1987 Jun 18;316(25):1607–1608. [PubMed]
  • Dieterich DT, Rahmin M. Cytomegalovirus colitis in AIDS: presentation in 44 patients and a review of the literature. J Acquir Immune Defic Syndr. 1991;4 (Suppl 1):S29–S35. [PubMed]
  • Foucar E, Mukai K, Foucar K, Sutherland DE, Van Buren CT. Colon ulceration in lethal cytomegalovirus infection. Am J Clin Pathol. 1981 Dec;76(6):788–801. [PubMed]
  • Henson D. Cytomegalovirus inclusion bodies in the gastrointestinal tract. Arch Pathol. 1972 Jun;93(6):477–482. [PubMed]
  • Thuluvath PJ, Connolly GM, Forbes A, Gazzard BG. Abdominal pain in HIV infection. Q J Med. 1991 Mar;78(287):275–285. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press