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J R Soc Med. 1994 April; 87(4): 200–202.
PMCID: PMC1294440

Pathogenesis of vertebral crush fractures in women.

Abstract

In a series of 214 women with vertebral crush fractures, 119 (55.6%) were found to have either an underlying secondary cause of osteoporosis or an early menopause before the age of 45 or both. A secondary cause of osteoporosis was present in 65 women (30.4%), the most common of which was corticosteroid therapy (13.6%) followed by previous or present hyperthyroidism (7.5%). Seventy-eight women (36.4%) had undergone menopause before the age of 45, occurring naturally in 55 (25.7%) and after surgery in 23 women (10.7%). We conclude that secondary osteoporosis and early menopause are major causes of vertebral crush fractures in women. We suggest that wider use of hormone replacement therapy following early menopause and prompt recognition and treatment of secondary causes of osteoporosis may reduce the risk of vertebral crush fractures in women.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Riggs BL, Melton LJ., 3rd Involutional osteoporosis. N Engl J Med. 1986 Jun 26;314(26):1676–1686. [PubMed]
  • Seeman E, Melton LJ, 3rd, O'Fallon WM, Riggs BL. Risk factors for spinal osteoporosis in men. Am J Med. 1983 Dec;75(6):977–983. [PubMed]
  • Francis RM, Peacock M, Marshall DH, Horsman A, Aaron JE. Spinal osteoporosis in men. Bone Miner. 1989 Mar;5(3):347–357. [PubMed]
  • Baillie SP, Davison CE, Johnson FJ, Francis RM. Pathogenesis of vertebral crush fractures in men. Age Ageing. 1992 Mar;21(2):139–141. [PubMed]
  • Bungay GT, Vessey MP, McPherson CK. Study of symptoms in middle life with special reference to the menopause. Br Med J. 1980 Jul 19;281(6234):181–183. [PMC free article] [PubMed]
  • Beard CM, Melton LJ, 3rd, Cedel SL, Richelson LS, Riggs BL. Ascertainment of risk factors for osteoporosis: comparison of interview data with medical record review. J Bone Miner Res. 1990 Jul;5(7):691–699. [PubMed]
  • Johnson BE, Lucasey B, Robinson RG, Lukert BP. Contributing diagnoses in osteoporosis. The value of a complete medical evaluation. Arch Intern Med. 1989 May;149(5):1069–1072. [PubMed]
  • Khaw KT. Epidemiology of the menopause. Br Med Bull. 1992 Apr;48(2):249–261. [PubMed]
  • Aloia JF, Cohn SH, Vaswani A, Yeh JK, Yuen K, Ellis K. Risk factors for postmenopausal osteoporosis. Am J Med. 1985 Jan;78(1):95–100. [PubMed]
  • Kleerekoper M, Peterson E, Nelson D, Tilley B, Phillips E, Schork MA, Kuder J. Identification of women at risk for developing postmenopausal osteoporosis with vertebral fractures: role of history and single photon absorptiometry. Bone Miner. 1989 Sep;7(2):171–186. [PubMed]
  • Elders PJ, Netelenbos JC, Lips P, Khoe E, van Ginkel FC, Hulshof KF, van der Stelt PF. Perimenopausal bone mass and risk factors. Bone Miner. 1989 Nov;7(3):289–299. [PubMed]
  • Slemenda CW, Hui SL, Longcope C, Wellman H, Johnston CC., Jr Predictors of bone mass in perimenopausal women. A prospective study of clinical data using photon absorptiometry. Ann Intern Med. 1990 Jan 15;112(2):96–101. [PubMed]
  • Hansen MA, Overgaard K, Riis BJ, Christiansen C. Potential risk factors for development of postmenopausal osteoporosis--examined over a 12-year period. Osteoporos Int. 1991 Feb;1(2):95–102. [PubMed]
  • Ribot C, Pouilles JM, Bonneu M, Tremollieres F. Assessment of the risk of post-menopausal osteoporosis using clinical factors. Clin Endocrinol (Oxf) 1992 Mar;36(3):225–228. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press