Search tips
Search criteria 


Logo of jrsocmedLink to Publisher's site
J R Soc Med. 1994 January; 87(1): 9–12.
PMCID: PMC1294271

Susceptibility of Helicobacter pylori to the antibacterial activity of manuka honey.


Honey is a traditional remedy for dyspepsia, and is still used for this by some medical practitioners although there is no rational basis for its use. The finding that Helicobacter pylori is probably the causative agent in many cases of dyspepsia has raised the possibility that the therapeutic action of honey may be due to its antibacterial properties. Consequently, the sensitivity of Helicobacter pylori to honey was tested, using isolates from biopsies of gastric ulcers. It was found that all five isolates tested were sensitive to a 20% (v/v) solution of manuka honey in an agar well diffusion assay, but none showed sensitivity to a 40% solution of a honey in which the antibacterial activity was due primarily to its content of hydrogen peroxide. Assessment of the minimum inhibitory concentration by inclusion of manuka honey in the agar showed that all seven isolates tested had visible growth over the incubation period of 72 h prevented completely by the presence of 5% (v/v) honey.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (809K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Zumla A, Lulat A. Honey--a remedy rediscovered. J R Soc Med. 1989 Jul;82(7):384–385. [PMC free article] [PubMed]
  • Bardhan KD, Cole DS, Hawkins BW, Franks CR. Does treatment with cimetidine extended beyond initial healing of duodenal ulcer reduce the subsequent relapse rate? Br Med J (Clin Res Ed) 1982 Feb 27;284(6316):621–623. [PMC free article] [PubMed]
  • Boyd EJ, Penston JG, Johnston DA, Wormsley KG. Does maintenance therapy keep duodenal ulcers healed? Lancet. 1988 Jun 11;1(8598):1324–1327. [PubMed]
  • Wade AG, Rowley-Jones D. Long term management of duodenal ulcer in general practice: how best to use cimetidine? Br Med J (Clin Res Ed) 1988 Apr 2;296(6627):971–974. [PMC free article] [PubMed]
  • Dooley CP, Cohen H. The clinical significance of Campylobacter pylori. Ann Intern Med. 1988 Jan;108(1):70–79. [PubMed]
  • Mégraud F, Lamouliatte H. Helicobacter pylori and duodenal ulcer. Evidence suggesting causation. Dig Dis Sci. 1992 May;37(5):769–772. [PubMed]
  • Rauws EA, Tytgat GN. Cure of duodenal ulcer associated with eradication of Helicobacter pylori. Lancet. 1990 May 26;335(8700):1233–1235. [PubMed]
  • Hentschel E, Nemec H, Schütze K, Hirschl A, Dragosics B, Brandstätter G, Taufer M. Duodenal ulcer recurrence and Helicobacter pylori. Lancet. 1991 Aug 31;338(8766):569–569. [PubMed]
  • Morris A, Lane M, Hamilton I, Samarasinghe D, Ali MR, Brown P, Nicholson G. Duodenal ulcer relapse after eradication of Helicobacter pylori. N Z Med J. 1991 Aug 14;104(917):329–331. [PubMed]
  • Moss S, Calam J. Helicobacter pylori and peptic ulcers: the present position. Gut. 1992 Mar;33(3):289–292. [PMC free article] [PubMed]
  • Allen KL, Molan PC, Reid GM. A survey of the antibacterial activity of some New Zealand honeys. J Pharm Pharmacol. 1991 Dec;43(12):817–822. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press