Search tips
Search criteria 


Logo of jrsocmedLink to Publisher's site
J R Soc Med. 1994; 87(Suppl 23): 2–4.
PMCID: PMC1294169

Pharmacokinetics of drugs in the elderly.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (593K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Castleden CM, Pickles H. Suspected adverse drug reactions in elderly patients reported to the Committee on Safety of Medicines. Br J Clin Pharmacol. 1988 Oct;26(4):347–353. [PMC free article] [PubMed]
  • BARON JH. Studies of basal and peak acid output with an augmented histamine test. Gut. 1963 Jun;4:136–144. [PMC free article] [PubMed]
  • Woodhouse KW, Wynne HA. Age-related changes in liver size and hepatic blood flow. The influence on drug metabolism in the elderly. Clin Pharmacokinet. 1988 Nov;15(5):287–294. [PubMed]
  • Cusack B, Kelly J, O'Malley K, Noel J, Lavan J, Horgan J. Digoxin in the elderly: pharmacokinetic consequences of old age. Clin Pharmacol Ther. 1979 Jun;25(6):772–776. [PubMed]
  • Castleden CM, Volans CN, Raymond K. The effect of ageing on drug absorption from the gut. Age Ageing. 1977 Aug;6(3):138–143. [PubMed]
  • Regårdh CG, Landahl S, Larsson M, Lundborg P, Steen B, Hoffmann KJ, Lagerström PO. Pharmacokinetics of metoprolol and its metabolite alpha-OH-metoprolol in healthy, non-smoking, elderly individuals. Eur J Clin Pharmacol. 1983;24(2):221–226. [PubMed]
  • Robertson DR, Waller DG, Renwick AG, George CF. Age-related changes in the pharmacokinetics and pharmacodynamics of nifedipine. Br J Clin Pharmacol. 1988 Mar;25(3):297–305. [PMC free article] [PubMed]
  • EDELMAN IS, LEIBMAN J. Anatomy of body water and electrolytes. Am J Med. 1959 Aug;27:256–277. [PubMed]
  • Vestal RE, McGuire EA, Tobin JD, Andres R, Norris AH, Mezey E. Aging and ethanol metabolism. Clin Pharmacol Ther. 1977 Mar;21(3):343–354. [PubMed]
  • Klotz U, Avant GR, Hoyumpa A, Schenker S, Wilkinson GR. The effects of age and liver disease on the disposition and elimination of diazepam in adult man. J Clin Invest. 1975 Feb;55(2):347–359. [PMC free article] [PubMed]
  • Allen MD, Greenblatt DJ, Harmatz JS, Shader RI. Desmethyldiazepam kinetics in the elderly after oral prazepam. Clin Pharmacol Ther. 1980 Aug;28(2):196–202. [PubMed]
  • Simon JB, Poon RW. Hepatic cholesterol ester hydrolase in human liver disease. Gastroenterology. 1978 Sep;75(3):470–473. [PubMed]
  • Christensen JH, Andreasen F, Jansen JA. Influence of age and sex on the pharmacokinetics of thiopentone. Br J Anaesth. 1981 Nov;53(11):1189–1195. [PubMed]
  • MILLER JH, McDONALD RK, SHOCK NW. Age changes in the maximal rate of renal tubular reabsorption of glucose. J Gerontol. 1952 Apr;7(2):196–200. [PubMed]
  • Lindeman RD, Tobin J, Shock NW. Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc. 1985 Apr;33(4):278–285. [PubMed]
  • Wynne HA, Cope LH, Mutch E, Rawlins MD, Woodhouse KW, James OF. The effect of age upon liver volume and apparent liver blood flow in healthy man. Hepatology. 1989 Feb;9(2):297–301. [PubMed]
  • Schmucker DL. Aging and drug disposition: an update. Pharmacol Rev. 1985 Jun;37(2):133–148. [PubMed]
  • Schmucker DL, Woodhouse KW, Wang RK, Wynne H, James OF, McManus M, Kremers P. Effects of age and gender on in vitro properties of human liver microsomal monooxygenases. Clin Pharmacol Ther. 1990 Oct;48(4):365–374. [PubMed]
  • Herd B, Wynne H, Wright P, James O, Woodhouse K. The effect of age on glucuronidation and sulphation of paracetamol by human liver fractions. Br J Clin Pharmacol. 1991 Dec;32(6):768–770. [PMC free article] [PubMed]
  • Woodhouse K, Herd B. The effect of age and gender on glucuronidation and sulphation in rat liver: a study using paracetamol as a model substrate. Arch Gerontol Geriatr. 1993 Mar-Apr;16(2):111–115. [PubMed]
  • Williams FM, Wynne H, Woodhouse KW, Rawlins MD. Plasma aspirin esterase: the influence of old age and frailty. Age Ageing. 1989 Jan;18(1):39–42. [PubMed]
  • Woodhouse KW, Wynne H, Baillie S, James OF, Rawlins MD. Who are the frail elderly? Q J Med. 1988 Jul;68(255):505–506. [PubMed]
  • Wynne HA, Cope LH, Herd B, Rawlins MD, James OF, Woodhouse KW. The association of age and frailty with paracetamol conjugation in man. Age Ageing. 1990 Nov;19(6):419–424. [PubMed]
  • George G, Wynne HA, Woodhouse KW. The association of age with the induction of drug-metabolizing enzymes in human monocytes. Age Ageing. 1990 Nov;19(6):364–367. [PubMed]
  • George G, Woodhouse K. Dose dependent induction of the microsomal monooxygenase aryl hydrocarbon hydroxylase in isolated peripheral blood monocytes: the influence of age. Pharmacol Toxicol. 1992 Sep;71(3 Pt 1):221–223. [PubMed]
  • George G, Wynne H, Woodhouse K. Age and the rate of induction of aryl hydrocarbon hydroxylase in isolated peripheral blood monocytes. Age Ageing. 1991 Nov;20(6):421–423. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press