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J R Soc Med. 1993 May; 86(5): 259–260.
PMCID: PMC1293999

Serum alpha interferon in children with right iliac fossa pain.


Serum alpha-interferon levels were analysed in 50 consecutive children admitted with right iliac fossa pain. Serum alpha-interferon levels were significantly raised in 33% of children without acute appendicitis when compared to 5.7% of children with histologically proven acute appendicitis and 9% of normal controls. This interesting phenomenon needs further investigation. A larger series may show it to be of clinical use in non-specific abdominal pain in childhood.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Ho-Yen DO, Carrington D. Alpha-interferon responses in cerebrospinal fluid of patients with suspected meningitis. J Clin Pathol. 1987 Jan;40(1):83–86. [PMC free article] [PubMed]
  • Deutsch AA, Shani N, Reiss R. Are some some appendectomies unnecessary? An analysis of 319 white appendices. J R Coll Surg Edinb. 1983 Jan;28(1):35–40. [PubMed]
  • Hoffmann J, Rasmussen OO. Aids in the diagnosis of acute appendicitis. Br J Surg. 1989 Aug;76(8):774–779. [PubMed]
  • Ingram RR, Mohammed R, Tillman J. C-reactive protein and acute appendicitis. J R Coll Surg Edinb. 1988 Jun;33(3):115–116. [PubMed]
  • Peltola H, Ahlqvist J, Rapola J, Räsänen J, Louhimo I, Saarinen M, Eskola J. C-reactive protein compared with white blood cell count and erythrocyte sedimentation rate in the diagnosis of acute appendicitis in children. Acta Chir Scand. 1986 Jan;152:55–58. [PubMed]
  • Davies AH, Bernau F, Salisbury A, Souter RG. C-reactive protein in right iliac fossa pain. J R Coll Surg Edinb. 1991 Aug;36(4):242–244. [PubMed]

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