PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jrsocmedLink to Publisher's site
 
J R Soc Med. 1993 April; 86(4): 219–224.
PMCID: PMC1293954

Uses and limitations of monoclonal antibodies (MoAbs) in the treatment of malignant disease: a review.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.5M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Hamilton RG. Monoclonal antibodies in the diagnosis and treatment of human diseases. Ann Biol Clin (Paris) 1989;47(10):575–581. [PubMed]
  • Jansen FK, Blythman HE, Carrière D, Casellas P, Gros O, Gros P, Laurent JC, Paolucci F, Pau B, Poncelet P, et al. Immunotoxins: hybrid molecules combining high specificity and potent cytotoxicity. Immunol Rev. 1982;62:185–216. [PubMed]
  • Jones DH, Goldman A, Gordon I, Pritchard J, Gregory BJ, Kemshead JT. Therapeutic application of a radiolabelled monoclonal antibody in nude mice xenografted with human neuroblastoma: tumoricidal effects and distribution studies. Int J Cancer. 1985 Jun 15;35(6):715–720. [PubMed]
  • Colcher D, Keenan AM, Larson SM, Schlom J. Prolonged binding of a radiolabeled monoclonal antibody (B72.3) used for the in situ radioimmunodetection of human colon carcinoma xenografts. Cancer Res. 1984 Dec;44(12 Pt 1):5744–5751. [PubMed]
  • Esteban JM, Colcher D, Sugarbaker P, Carrasquillo JA, Bryant G, Thor A, Reynolds JC, Larson SM, Schlom J. Quantitative and qualitative aspects of radiolocalization in colon cancer patients of intravenously administered MAb B72.3. Int J Cancer. 1987 Jan 15;39(1):50–59. [PubMed]
  • Jain RK. Transport of molecules across tumor vasculature. Cancer Metastasis Rev. 1987;6(4):559–593. [PubMed]
  • Zalutsky MR, Noska MA, Colapinto EV, Garg PK, Bigner DD. Enhanced tumor localization and in vivo stability of a monoclonal antibody radioiodinated using N-succinimidyl 3-(tri-n-butylstannyl)benzoate. Cancer Res. 1989 Oct 15;49(20):5543–5549. [PubMed]
  • Lashford LS, Hancock JP, Kemshead JT. Meta-iodobenzylguanidine (mIBG) uptake and storage in the human neuroblastoma cell line SK-N-BE(2C). Int J Cancer. 1991 Jan 2;47(1):105–109. [PubMed]
  • Shapiro B, Copp JE, Sisson JC, Eyre PL, Wallis J, Beierwaltes WH. Iodine-131 metaiodobenzylguanidine for the locating of suspected pheochromocytoma: experience in 400 cases. J Nucl Med. 1985 Jun;26(6):576–585. [PubMed]
  • Lewis IJ, Lashford LS, Fielding S, Flower MA, Ackery D, Kemshead J. A phase I/II study of 131I mIBG in chemo-resistant neuroblastoma. The United Kingdom Children's Cancer Study Group (UKCCSG). Prog Clin Biol Res. 1991;366:463–469. [PubMed]
  • Lee YS, Bullard DE, Wikstrand CJ, Zalutsky MR, Muhlbaier LH, Bigner DD. Comparison of monoclonal antibody delivery to intracranial glioma xenografts by intravenous and intracarotid administration. Cancer Res. 1987 Apr 1;47(7):1941–1946. [PubMed]
  • Kemshead JT, Jones DH, Lashford L, Prichard J, Gordon I, Breatnach F, Coakham HB. 131-I coupled to monoclonal antibodies as therapeutic agents for neuroectodermally derived tumors: fact or fiction? Cancer Drug Deliv. 1986 Winter;3(1):25–43. [PubMed]
  • Hertler AA, Frankel AE. Immunotoxins: a clinical review of their use in the treatment of malignancies. J Clin Oncol. 1989 Dec;7(12):1932–1942. [PubMed]
  • Engert A, Martin G, Amlot P, Wijdenes J, Diehl V, Thorpe P. Immunotoxins constructed with anti-CD25 monoclonal antibodies and deglycosylated ricin A-chain have potent anti-tumour effects against human Hodgkin cells in vitro and solid Hodgkin tumours in mice. Int J Cancer. 1991 Sep 30;49(3):450–456. [PubMed]
  • Press OW, Eary JF, Badger CC, Martin PJ, Appelbaum FR, Nelp WB, Krohn KA, Fisher D, Porter B, Thomas ED, et al. High-dose radioimmunotherapy of B cell lymphomas. Front Radiat Ther Oncol. 1990;24:204–227. [PubMed]
  • Dillman RO, Shawler DL, Sobol RE, Collins HA, Beauregard JC, Wormsley SB, Royston I. Murine monoclonal antibody therapy in two patients with chronic lymphocytic leukemia. Blood. 1982 May;59(5):1036–1045. [PubMed]
  • Epenetos AA, Munro AJ, Stewart S, Rampling R, Lambert HE, McKenzie CG, Soutter P, Rahemtulla A, Hooker G, Sivolapenko GB, et al. Antibody-guided irradiation of advanced ovarian cancer with intraperitoneally administered radiolabeled monoclonal antibodies. J Clin Oncol. 1987 Dec;5(12):1890–1899. [PubMed]
  • Hird V, Stewart JS, Snook D, Dhokia B, Coulter C, Lambert HE, Mason WP, Soutter WP, Epenetos AA. Intraperitoneally administered 90Y-labelled monoclonal antibodies as a third line of treatment in ovarian cancer. A phase 1-2 trial: problems encountered and possible solutions. Br J Cancer Suppl. 1990 Jul;10:48–51. [PubMed]
  • Moseley RP, Davies AG, Richardson RB, Zalutsky M, Carrell S, Fabre J, Slack N, Bullimore J, Pizer B, Papanastassiou V, et al. Intrathecal administration of 131I radiolabelled monoclonal antibody as a treatment for neoplastic meningitis. Br J Cancer. 1990 Oct;62(4):637–642. [PMC free article] [PubMed]
  • Pizer B, Papanastassiou V, Hancock J, Cassano W, Coakham H, Kemshead J. A pilot study of monoclonal antibody targeted radiotherapy in the treatment of central nervous system leukaemia in children. Br J Haematol. 1991 Apr;77(4):466–472. [PubMed]
  • Brady LW, Markoe AM, Woo DV, Amendola BE, Karlsson UL, Rackover MA, Koprowski H, Steplewski Z, Peyster RG. Iodine-125-labeled anti-epidermal growth factor receptor-425 in the treatment of glioblastoma multiforme. A pilot study. Front Radiat Ther Oncol. 1990;24:151–165. [PubMed]
  • Brady LW, Markoe AM, Woo DV, Rackover MA, Koprowski H, Steplewski Z, Peyster RG. Iodine125 labeled anti-epidermal growth factor receptor-425 in the treatment of malignant astrocytomas. A pilot study. J Neurosurg Sci. 1990 Jul-Dec;34(3-4):243–249. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press