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J R Soc Med. 1993 April; 86(4): 212–216.
PMCID: PMC1293952

The genetic mosaic.

Abstract

Blaschko's lines are the acknowledged markers which represent the patterns of systematized naevi. Their interpretation has remained mysterious, because certain special features which they exhibit are impossible to reconcile with any known anatomical system in the human body. It is proposed that by changing one's views on the nature and growth of the dermatome, the patterns of zoster, and the behaviour of tissue mosaicism, the major difficulties hitherto experienced will be overcome.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Happle R, Fuhrmann-Rieger A, Fuhrmann W. Wie verlaufen die Blaschko-Linien am behaarten Kopf? Hautarzt. 1984 Jul;35(7):366–369. [PubMed]
  • Happle R. Lyonization and the lines of Blaschko. Hum Genet. 1985;70(3):200–206. [PubMed]
  • Happle R. Lethal genes surviving by mosaicism: a possible explanation for sporadic birth defects involving the skin. J Am Acad Dermatol. 1987 Apr;16(4):899–906. [PubMed]
  • Findlay GH, Moores PP. Pigment anomalies of the skin in the human chimaera: their relation to systematized naevi. Br J Dermatol. 1980 Nov;103(5):489–498. [PubMed]

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