Search tips
Search criteria 


Logo of jrsocmedLink to Publisher's site
J R Soc Med. 1993 April; 86(4): 212–216.
PMCID: PMC1293952

The genetic mosaic.


Blaschko's lines are the acknowledged markers which represent the patterns of systematized naevi. Their interpretation has remained mysterious, because certain special features which they exhibit are impossible to reconcile with any known anatomical system in the human body. It is proposed that by changing one's views on the nature and growth of the dermatome, the patterns of zoster, and the behaviour of tissue mosaicism, the major difficulties hitherto experienced will be overcome.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (2.8M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Happle R, Fuhrmann-Rieger A, Fuhrmann W. Wie verlaufen die Blaschko-Linien am behaarten Kopf? Hautarzt. 1984 Jul;35(7):366–369. [PubMed]
  • Happle R. Lyonization and the lines of Blaschko. Hum Genet. 1985;70(3):200–206. [PubMed]
  • Happle R. Lethal genes surviving by mosaicism: a possible explanation for sporadic birth defects involving the skin. J Am Acad Dermatol. 1987 Apr;16(4):899–906. [PubMed]
  • Findlay GH, Moores PP. Pigment anomalies of the skin in the human chimaera: their relation to systematized naevi. Br J Dermatol. 1980 Nov;103(5):489–498. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press