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J R Soc Med. 1993 January; 86(1): 24–25.
PMCID: PMC1293818

Venous ulceration in males with sex chromosome abnormalities.


Two patients with Klinefelter's syndrome and three with 47,XYY who had venous ulcers, and one patient with 47,XYY and a post thrombotic limb are described. Sex chromosome abnormalities should be suspected in tall males with leg ulcers, especially those who have no progeny and are relatively young. Venous ulcers may be more common in males with 47,XYY.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Campbell WA, Newton MS, Price WH. Hypostatic leg ulceration and Klinefelter's syndrome. J Ment Defic Res. 1980 Jun;24(2):115–117. [PubMed]
  • Forssman Hans, Wallin Leif. Hypostatic ulceration and male sex chromosomal anomalies. Br Med J. 1978 Aug 05;2(6134):c434–434. [PMC free article]
  • Callam MJ, Ruckley CV, Harper DR, Dale JJ. Chronic ulceration of the leg: extent of the problem and provision of care. Br Med J (Clin Res Ed) 1985 Jun 22;290(6485):1855–1856. [PMC free article] [PubMed]
  • Andersen KE. Sex chromosomal anomalies: a possible association with leg ulcers. Clin Exp Dermatol. 1979 Jun;4(2):223–226. [PubMed]
  • Brown WM, Price WH, Jacobs PA. Further information on the identity of 47,XYY males. Br Med J. 1968 May 11;2(5601):325–328. [PMC free article] [PubMed]
  • SANDBERG AA, KOEPF GF, ISHIHARA T, HAUSCHKA TS. An XYY human male. Lancet. 1961 Aug 26;2(7200):488–489. [PubMed]

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