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J R Soc Med. 1993; 86(Suppl 20): 11–18.
PMCID: PMC1293798

Microbiology of cystic fibrosis lung infections: themes and issues.

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Selected References

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  • Høiby N, Koch C. Cystic fibrosis. 1. Pseudomonas aeruginosa infection in cystic fibrosis and its management. Thorax. 1990 Nov;45(11):881–884. [PMC free article] [PubMed]
  • Gilligan PH. Microbiology of airway disease in patients with cystic fibrosis. Clin Microbiol Rev. 1991 Jan;4(1):35–51. [PMC free article] [PubMed]
  • Govan JR, Nelson JW. Microbiology of lung infection in cystic fibrosis. Br Med Bull. 1992 Oct;48(4):912–930. [PubMed]
  • Tsang V, Hodson ME, Yacoub MH. Lung transplantation for cystic fibrosis. Br Med Bull. 1992 Oct;48(4):949–971. [PubMed]
  • Høiby N, Döring G, Schiøtz PO. The role of immune complexes in the pathogenesis of bacterial infections. Annu Rev Microbiol. 1986;40:29–53. [PubMed]
  • Dasgupta MK, Lam J, Döring G, Harley FL, Zuberbuhler P, Lam K, Reichert A, Costerton JW, Dossetor JB. Prognostic implications of circulating immune complexes and Pseudomonas aeruginosa-specific antibodies in cystic fibrosis. J Clin Lab Immunol. 1987 May;23(1):25–30. [PubMed]
  • Warner JO. Immunology of cystic fibrosis. Br Med Bull. 1992 Oct;48(4):893–911. [PubMed]
  • Moss RB, Lewiston NJ. Immune complexes and humoral response to Pseudomonas aeruginosa in cystic fibrosis. Am Rev Respir Dis. 1980 Jan;121(1):23–29. [PubMed]
  • Cukor G, Blacklow NR, Nowak NA, Rich CM, Braverman LE, Fischer RA. Comparative analysis of serum antibody responses to Pseudomonas aeruginosa exotoxin A by cystic fibrosis and intensive care unit patients. J Clin Microbiol. 1983 Sep;18(3):457–462. [PMC free article] [PubMed]
  • Wheeler WB, Williams M, Matthews WJ, Jr, Colten HR. Progression of cystic fibrosis lung disease as a function of serum immunoglobulin G levels: a 5-year longitudinal study. J Pediatr. 1984 May;104(5):695–699. [PubMed]
  • Pedersen SS, Høiby N, Shand GH, Pressler T. Antibody response to Pseudomonas aeruginosa antigens in cystic fibrosis. Antibiot Chemother (1971) 1989;42:130–153. [PubMed]
  • Döring G, Høiby N. Longitudinal study of immune response to Pseudomonas aeruginosa antigens in cystic fibrosis. Infect Immun. 1983 Oct;42(1):197–201. [PMC free article] [PubMed]
  • Döring G, Goldstein W, Röll A, Schiøtz PO, Høiby N, Botzenhart K. Role of Pseudomonas aeruginosa exoenzymes in lung infections of patients with cystic fibrosis. Infect Immun. 1985 Sep;49(3):557–562. [PMC free article] [PubMed]
  • Hollsing AE, Granström M, Vasil ML, Wretlind B, Strandvik B. Prospective study of serum antibodies to Pseudomonas aeruginosa exoproteins in cystic fibrosis. J Clin Microbiol. 1987 Oct;25(10):1868–1874. [PMC free article] [PubMed]
  • Pier GB, Saunders JM, Ames P, Edwards MS, Auerbach H, Goldfarb J, Speert DP, Hurwitch S. Opsonophagocytic killing antibody to Pseudomonas aeruginosa mucoid exopolysaccharide in older noncolonized patients with cystic fibrosis. N Engl J Med. 1987 Sep 24;317(13):793–798. [PubMed]
  • Fomsgaard A, Høiby N, Shand GH, Conrad RS, Galanos C. Longitudinal study of antibody response to lipopolysaccharides during chronic Pseudomonas aeruginosa lung infection in cystic fibrosis. Infect Immun. 1988 Sep;56(9):2270–2278. [PMC free article] [PubMed]
  • Hancock RE, Mouat EC, Speert DP. Quantitation and identification of antibodies to outer-membrane proteins of Pseudomonas aeruginosa in sera of patients with cystic fibrosis. J Infect Dis. 1984 Feb;149(2):220–226. [PubMed]
  • Anderson TR, Montie TC, Murphy MD, McCarthy VP. Pseudomonas aeruginosa flagellar antibodies in patients with cystic fibrosis. J Clin Microbiol. 1989 Dec;27(12):2789–2793. [PMC free article] [PubMed]
  • Shand GH, Pedersen SS, Lam K, Høiby N. Iron-regulated outer membrane proteins and virulence in Pseudomonas aeruginosa. Antibiot Chemother (1971) 1989;42:15–26. [PubMed]
  • Brett MM, Ghoneim AT, Littlewood JM, Losowsky MS. Development of enzyme linked immunosorbent assay (ELISA) to detect antibodies to Pseudomonas aeruginosa cell surface antigens in sera of patients with cystic fibrosis. J Clin Pathol. 1986 Oct;39(10):1124–1129. [PMC free article] [PubMed]
  • Pedersen SS, Espersen F, Høiby N. Diagnosis of chronic Pseudomonas aeruginosa infection in cystic fibrosis by enzyme-linked immunosorbent assay. J Clin Microbiol. 1987 Oct;25(10):1830–1836. [PMC free article] [PubMed]
  • Brett MM, Ghoneim AT, Littlewood JM. Prediction and diagnosis of early Pseudomonas aeruginosa infection in cystic fibrosis: a follow-up study. J Clin Microbiol. 1988 Aug;26(8):1565–1570. [PMC free article] [PubMed]
  • Shand GH, Pedersen SS, Tilling R, Brown MR, Høiby N. Use of immunoblot detection of serum antibodies in the diagnosis of chronic Pseudomonas aeruginosa lung infection in cystic fibrosis. J Med Microbiol. 1988 Nov;27(3):169–177. [PubMed]
  • Brett MM, Ghoneim AT, Littlewood JM. Serum IgA antibodies against Pseudomonas aeruginosa in cystic fibrosis. Arch Dis Child. 1990 Mar;65(3):259–263. [PMC free article] [PubMed]
  • Cordon SM, Elborn JS, Rayner RJ, Hiller EJ, Shale DJ. IgG antibodies in early Pseudomonas aeruginosa infection in cystic fibrosis. Arch Dis Child. 1992 Jun;67(6):737–740. [PMC free article] [PubMed]
  • Schiøtz PO, Høiby N, Permin H, Wiik A. IgA and IgG antibodies against surface antigens of Pseudomonas aeruginosa in sputum and serum from patients with cystic fibrosis. Acta Pathol Microbiol Scand C. 1979 Jun;87C(3):229–233. [PubMed]
  • Przyklenk B, Bauernfeind A. Significance of immunologic factors in cystic fibrosis. Scand J Gastroenterol Suppl. 1988;143:103–109. [PubMed]
  • Finlay BB, Falkow S. Common themes in microbial pathogenicity. Microbiol Rev. 1989 Jun;53(2):210–230. [PMC free article] [PubMed]
  • Woods DE, Straus DC, Johanson WG, Jr, Berry VK, Bass JA. Role of pili in adherence of Pseudomonas aeruginosa to mammalian buccal epithelial cells. Infect Immun. 1980 Sep;29(3):1146–1151. [PMC free article] [PubMed]
  • Baltimore RS, Christie CD, Smith GJ. Immunohistopathologic localization of Pseudomonas aeruginosa in lungs from patients with cystic fibrosis. Implications for the pathogenesis of progressive lung deterioration. Am Rev Respir Dis. 1989 Dec;140(6):1650–1661. [PubMed]
  • Jeffery PK, Brain AP. Surface morphology of human airway mucosa: normal, carcinoma or cystic fibrosis. Scanning Microsc. 1988 Mar;2(1):553–560. [PubMed]
  • Plotkowski MC, Chevillard M, Pierrot D, Altemayer D, Zahm JM, Colliot G, Puchelle E. Differential adhesion of Pseudomonas aeruginosa to human respiratory epithelial cells in primary culture. J Clin Invest. 1991 Jun;87(6):2018–2028. [PMC free article] [PubMed]
  • Vishwanath S, Ramphal R. Adherence of Pseudomonas aeruginosa to human tracheobronchial mucin. Infect Immun. 1984 Jul;45(1):197–202. [PMC free article] [PubMed]
  • Vishwanath S, Ramphal R. Tracheobronchial mucin receptor for Pseudomonas aeruginosa: predominance of amino sugars in binding sites. Infect Immun. 1985 May;48(2):331–335. [PMC free article] [PubMed]
  • Nelson JW, Tredgett MW, Sheehan JK, Thornton DJ, Notman D, Govan JR. Mucinophilic and chemotactic properties of Pseudomonas aeruginosa in relation to pulmonary colonization in cystic fibrosis. Infect Immun. 1990 Jun;58(6):1489–1495. [PMC free article] [PubMed]
  • Sajjan US, Corey M, Karmali MA, Forstner JF. Binding of Pseudomonas cepacia to normal human intestinal mucin and respiratory mucin from patients with cystic fibrosis. J Clin Invest. 1992 Feb;89(2):648–656. [PMC free article] [PubMed]
  • Ramphal R. The role of bacterial adhesion in cystic fibrosis including the staphylococcal aspect. Infection. 1990 Jan-Feb;18(1):61–64. [PubMed]
  • Ramphal R, Carnoy C, Fievre S, Michalski JC, Houdret N, Lamblin G, Strecker G, Roussel P. Pseudomonas aeruginosa recognizes carbohydrate chains containing type 1 (Gal beta 1-3GlcNAc) or type 2 (Gal beta 1-4GlcNAc) disaccharide units. Infect Immun. 1991 Feb;59(2):700–704. [PMC free article] [PubMed]
  • Ramphal R, Guay C, Pier GB. Pseudomonas aeruginosa adhesins for tracheobronchial mucin. Infect Immun. 1987 Mar;55(3):600–603. [PMC free article] [PubMed]
  • Reddy MS. Human tracheobronchial mucin: purification and binding to Pseudomonas aeruginosa. Infect Immun. 1992 Apr;60(4):1530–1535. [PMC free article] [PubMed]
  • Langford DT, Hiller J. Prospective, controlled study of a polyvalent pseudomonas vaccine in cystic fibrosis--three year results. Arch Dis Child. 1984 Dec;59(12):1131–1134. [PMC free article] [PubMed]
  • Schaad UB, Lang AB, Wedgwood J, Ruedeberg A, Que JU, Fürer E, Cryz SJ., Jr Safety and immunogenicity of Pseudomonas aeruginosa conjugate A vaccine in cystic fibrosis. Lancet. 1991 Nov 16;338(8777):1236–1237. [PubMed]
  • Pier GB, Small GJ, Warren HB. Protection against mucoid Pseudomonas aeruginosa in rodent models of endobronchial infections. Science. 1990 Aug 3;249(4968):537–540. [PubMed]
  • Govan JR, Fyfe JA. Mucoid Pseudomonas aeruginosa and cystic fibrosis: resistance of the mucoid from to carbenicillin, flucloxacillin and tobramycin and the isolation of mucoid variants in vitro. J Antimicrob Chemother. 1978 May;4(3):233–240. [PubMed]
  • Govan JR, Doherty C, Glass S. Rational parameters for antibiotic therapy in patients with cystic fibrosis. Infection. 1987 Jul-Aug;15(4):300–307. [PubMed]
  • Littlewood JM, Miller MG, Ghoneim AT, Ramsden CH. Nebulised colomycin for early pseudomonas colonisation in cystic fibrosis. Lancet. 1985 Apr 13;1(8433):865–865. [PubMed]
  • Valerius NH, Koch C, Høiby N. Prevention of chronic Pseudomonas aeruginosa colonisation in cystic fibrosis by early treatment. Lancet. 1991 Sep 21;338(8769):725–726. [PubMed]
  • Glass S, Hayward C, Govan JR. Serum C-reactive protein in assessment of pulmonary exacerbations and antimicrobial therapy in cystic fibrosis. J Pediatr. 1988 Jul;113(1 Pt 1):76–79. [PubMed]
  • Rayner RJ, Wiseman MS, Cordon SM, Norman D, Hiller EJ, Shale DJ. Inflammatory markers in cystic fibrosis. Respir Med. 1991 Mar;85(2):139–145. [PubMed]
  • Vishwanath S, Guay CM, Ramphal R. Effects of subminimal inhibitory concentrations of antibiotics on the adherence of Pseudomonas aeruginosa to tracheobronchial mucin. J Antimicrob Chemother. 1987 May;19(5):579–583. [PubMed]
  • Geers TA, Baker NR. The effect of sublethal levels of antibiotics on the pathogenicity of Pseudomonas aeruginosa for tracheal tissue. J Antimicrob Chemother. 1987 May;19(5):569–578. [PubMed]
  • Isles A, Maclusky I, Corey M, Gold R, Prober C, Fleming P, Levison H. Pseudomonas cepacia infection in cystic fibrosis: an emerging problem. J Pediatr. 1984 Feb;104(2):206–210. [PubMed]
  • Thomassen MJ, Demko CA, Klinger JD, Stern RC. Pseudomonas cepacia colonization among patients with cystic fibrosis. A new opportunist. Am Rev Respir Dis. 1985 May;131(5):791–796. [PubMed]
  • Tablan OC, Carson LA, Cusick LB, Bland LA, Martone WJ, Jarvis WR. Laboratory proficiency test results on use of selective media for isolating Pseudomonas cepacia from simulated sputum specimens of patients with cystic fibrosis. J Clin Microbiol. 1987 Mar;25(3):485–487. [PMC free article] [PubMed]
  • Nelson JW, Doherty CJ, Brown PH, Greening AP, Kaufmann ME, Govan JR. Pseudomonas cepacia in inpatients with cystic fibrosis. Lancet. 1991 Dec 14;338(8781):1525–1525. [PubMed]
  • Beckman W, Lessie TG. Response of Pseudomonas cepacia to beta-Lactam antibiotics: utilization of penicillin G as the carbon source. J Bacteriol. 1979 Dec;140(3):1126–1128. [PMC free article] [PubMed]
  • Taylor RF, Gaya H, Hodson ME. Temocillin and cystic fibrosis: outcome of intravenous administration in patients infected with Pseudomonas cepacia. J Antimicrob Chemother. 1992 Mar;29(3):341–344. [PubMed]
  • LiPuma JJ, Dasen SE, Nielson DW, Stern RC, Stull TL. Person-to-person transmission of Pseudomonas cepacia between patients with cystic fibrosis. Lancet. 1990 Nov 3;336(8723):1094–1096. [PubMed]
  • Smith DL, Smith EG, Gumery LB, Stableforth DE. Pseudomonas cepacia infection in cystic fibrosis. Lancet. 1992 Jan 25;339(8787):252–252. [PubMed]
  • Gladman G, Connor PJ, Williams RF, David TJ. Controlled study of Pseudomonas cepacia and Pseudomonas maltophilia in cystic fibrosis. Arch Dis Child. 1992 Feb;67(2):192–195. [PMC free article] [PubMed]
  • Lonon MK, Woods DE, Straus DC. Production of lipase by clinical isolates of Pseudomonas cepacia. J Clin Microbiol. 1988 May;26(5):979–984. [PMC free article] [PubMed]
  • Gessner AR, Mortensen JE. Pathogenic factors of Pseudomonas cepacia isolates from patients with cystic fibrosis. J Med Microbiol. 1990 Oct;33(2):115–120. [PubMed]
  • Vasil ML, Krieg DP, Kuhns JS, Ogle JW, Shortridge VD, Ostroff RM, Vasil AI. Molecular analysis of hemolytic and phospholipase C activities of Pseudomonas cepacia. Infect Immun. 1990 Dec;58(12):4020–4029. [PMC free article] [PubMed]
  • Straus DC, Woods DE, Lonon MK, Garner CW. The importance of extracellular antigens in Pseudomonas cepacia infections. J Med Microbiol. 1988 Aug;26(4):269–280. [PubMed]
  • Aronoff SC, Stern RC. Serum IgG antibody to outer membrane antigens of Pseudomonas cepacia and Pseudomonas aeruginosa in cystic fibrosis. J Infect Dis. 1988 May;157(5):934–940. [PubMed]
  • Aronoff SC, Quinn FJ, Jr, Stern RC. Longitudinal serum IgG response to Pseudomonas cepacia surface antigens in cystic fibrosis. Pediatr Pulmonol. 1991;11(4):289–293. [PubMed]
  • Tablan OC, Martone WJ, Doershuk CF, Stern RC, Thomassen MJ, Klinger JD, White JW, Carson LA, Jarvis WR. Colonization of the respiratory tract with Pseudomonas cepacia in cystic fibrosis. Risk factors and outcomes. Chest. 1987 Apr;91(4):527–532. [PubMed]
  • Simmonds EJ, Conway SP, Ghoneim AT, Ross H, Littlewood JM. Pseudomonas cepacia: a new pathogen in patients with cystic fibrosis referred to a large centre in the United Kingdom. Arch Dis Child. 1990 Aug;65(8):874–877. [PMC free article] [PubMed]
  • Deretic V, Mohr CD, Martin DW. Mucoid Pseudomonas aeruginosa in cystic fibrosis: signal transduction and histone-like elements in the regulation of bacterial virulence. Mol Microbiol. 1991 Jul;5(7):1577–1583. [PubMed]
  • Dorin JR, Dickinson P, Alton EW, Smith SN, Geddes DM, Stevenson BJ, Kimber WL, Fleming S, Clarke AR, Hooper ML, et al. Cystic fibrosis in the mouse by targeted insertional mutagenesis. Nature. 1992 Sep 17;359(6392):211–215. [PubMed]
  • Pier GB, Meluleni G, Neuger E. A murine model of chronic mucosal colonization by Pseudomonas aeruginosa. Infect Immun. 1992 Nov;60(11):4768–4776. [PMC free article] [PubMed]

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