Search tips
Search criteria 


Logo of jrsocmedLink to Publisher's site
J R Soc Med. 1992 November; 85(11): 674–678.
PMCID: PMC1293725

Treatment of metastatic testicular tumours with bleomycin, etoposide, cisplatin and vincristine (BEPV).


Between August 1983 and December 1988, 47 patients with metastatic testicular tumours (44 non-seminomatous, three seminomas) were treated with two to six courses of bleomycin, etoposide, cisplatin and vincristine (BEPV). Five stage I tumours were included, three because of raised tumour markers following orchidectomy, one with vascular invasion of spermatic cord vessels and the other with both these features. Forty-four patients (93.6%) are alive and disease free 12-75 months (median 39 months) after completion of BEPV. Further treatment was necessary in 12 of the survivors. Eight had residual disease excised, one of whom received radiotherapy, one additional chemotherapy and one both radiotherapy and chemotherapy. Of the remaining four, two had radiotherapy and two second line chemotherapy. Thirty-one non-seminomatous and the three seminoma patients had small volume disease and all are in complete remission. Ten of the 13 patients with bulky disease are alive. It is concluded that BEPV is a well-tolerated, effective, first line therapy for patients with metastatic testicular tumour.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (869K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Waterhouse JA. Epidemiology of testicular tumours. J R Soc Med. 1985;78 (Suppl 6):3–7. [PMC free article] [PubMed]
  • Einhorn LH, Donohue J. Cis-diamminedichloroplatinum, vinblastine, and bleomycin combination chemotherapy in disseminated testicular cancer. Ann Intern Med. 1977 Sep;87(3):293–298. [PubMed]
  • Einhorn LH, Williams SD. Chemotherapy of disseminated testicular cancer. A random prospective study. Cancer. 1980 Sep 15;46(6):1339–1344. [PubMed]
  • Peckham MJ, McElwain TJ, Barrett A, Hendry WF. Combined management of malignant teratoma of the testis. Lancet. 1979 Aug 11;2(8137):267–270. [PubMed]
  • Peckham MJ, Barrett A, Liew KH, Horwich A, Robinson B, Dobbs HJ, McElwain TJ, Hendry WF. The treatment of metastatic germ-cell testicular tumours with bleomycin, etoposide and cis-platin (BEP). Br J Cancer. 1983 May;47(5):613–619. [PMC free article] [PubMed]
  • Fitzharris BM, Kaye SB, Saverymuttu S, Newlands ES, Barrett A, Peckham MJ, McElwain TJ. VP16-213 as a single agent in advanced testicular tumors. Eur J Cancer. 1980 Sep;16(9):1193–1197. [PubMed]
  • Cavalli F, Klepp O, Renard J, Röhrt M, Alberto P. A phase II study of oral VP-16-213 in non-seminomatous testicular cancer. Eur J Cancer. 1981 Feb;17(2):245–249. [PubMed]
  • Bremer K, Niederle N, Krischke W, Higi M, Scheulen ME, Schmidt CG, Seeber S. Etoposide and etoposide-ifosfamide therapy for refractory testicular tumors. Cancer Treat Rev. 1982 Jun;9 (Suppl):79–84. [PubMed]
  • Williams SD, Einhorn LH. Etoposide salvage therapy for refractory germ cell tumors: an update. Cancer Treat Rev. 1982 Jun;9 (Suppl):67–71. [PubMed]
  • Samuels ML, Howe CD. Vinblastine in the management of testicular cancer. Cancer. 1970 May;25(5):1009–1017. [PubMed]
  • Samuels ML, Holoye PY, Johnson DE. Bleomycin combination chemotherapy in the management of testicular neoplasia. Cancer. 1975 Aug;36(2):318–326. [PubMed]
  • Samuels ML, Johnson DE, Holoye PY. Continuous intravenous bleomycin (NSC-125066) therapy with vinblastine (NSC-49842) in stage III testicular neoplasia. Cancer Chemother Rep. 1975 May-Jun;59(3):563–570. [PubMed]
  • COSTA G, HRESHCHYSHYN MM, HOLLAND JF. Initial clinical studies with vincristine. Cancer Chemother Rep. 1962 Nov;24:39–44. [PubMed]
  • SHAW RK, BRUNER JA. CLINICAL EVALUATION OF VINCRISTINE (NSC-67574). Cancer Chemother Rep. 1964 Nov;42:45–48. [PubMed]
  • Wettlaufer JN, Feiner AS, Robinson WA. Vincristine, cisplatin, and bleomycin with surgery in the management of advanced metastatic nonseminomatous testis tumors. Cancer. 1984 Jan 15;53(2):203–209. [PubMed]
  • Newlands ES, Begent RH, Rustin GJ, Parker D, Bagshawe KD. Further advances in the management of malignant teratomas of the testis and other sites. Lancet. 1983 Apr 30;1(8331):948–951. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press