Search tips
Search criteria 


Logo of jrsocmedLink to Publisher's site
J R Soc Med. 1992 January; 85(1): 53–57.
PMCID: PMC1293469

Immunological mechanisms of demyelination.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.1M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bradbury MW. The structure and function of the blood-brain barrier. Fed Proc. 1984 Feb;43(2):186–190. [PubMed]
  • Broadwell RD. Transcytosis of macromolecules through the blood-brain barrier: a cell biological perspective and critical appraisal. Acta Neuropathol. 1989;79(2):117–128. [PubMed]
  • Sedgwick JD, Hughes CC, Male DK, MacPhee IA, ter Meulen V. Antigen-specific damage to brain vascular endothelial cells mediated by encephalitogenic and nonencephalitogenic CD4+ T cell lines in vitro. J Immunol. 1990 Oct 15;145(8):2474–2481. [PubMed]
  • Male D, Pyrce G, Hughes C, Lantos P. Lymphocyte migration into brain modelled in vitro: control by lymphocyte activation, cytokines, and antigen. Cell Immunol. 1990 Apr 15;127(1):1–11. [PubMed]
  • Cross AH, Cannella B, Brosnan CF, Raine CS. Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis. Lab Invest. 1990 Aug;63(2):162–170. [PubMed]
  • Schwartz RH. Immune response (Ir) genes of the murine major histocompatibility complex. Adv Immunol. 1986;38:31–201. [PubMed]
  • Wraith DC, McDevitt HO, Steinman L, Acha-Orbea H. T cell recognition as the target for immune intervention in autoimmune disease. Cell. 1989 Jun 2;57(5):709–715. [PubMed]
  • Wraith DC, Smilek DE, Mitchell DJ, Steinman L, McDevitt HO. Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy. Cell. 1989 Oct 20;59(2):247–255. [PubMed]
  • Urban JL, Horvath SJ, Hood L. Autoimmune T cells: immune recognition of normal and variant peptide epitopes and peptide-based therapy. Cell. 1989 Oct 20;59(2):257–271. [PubMed]
  • Lamont AG, Sette A, Fujinami R, Colón SM, Miles C, Grey HM. Inhibition of experimental autoimmune encephalomyelitis induction in SJL/J mice by using a peptide with high affinity for IAs molecules. J Immunol. 1990 Sep 15;145(6):1687–1693. [PubMed]
  • Quarles RH, Ilyas AA, Willison HJ. Antibodies to glycolipids in demyelinating diseases of the human peripheral nervous system. Chem Phys Lipids. 1986 Dec 15;42(1-3):235–248. [PubMed]
  • Gregson NA, Leibowitz S. IgM paraproteinaemia, polyneuropathy and myelin-associated glycoprotein (MAG). Neuropathol Appl Neurobiol. 1985 Sep-Oct;11(5):329–347. [PubMed]
  • Ilyas AA, Willison HJ, Dalakas MC, Whitaker JN, Quarles RH. Identification and characterization of gangliosides reacting with IgM paraproteins in three patients with neuropathy associated with biclonal gammopathy. J Neurochem. 1988 Sep;51(3):851–858. [PubMed]
  • Baba H, Daune GC, Ilyas AA, Pestronk A, Cornblath DR, Chaudhry V, Griffin JW, Quarles RH. Anti-GM1 ganglioside antibodies with differing fine specificities in patients with multifocal motor neuropathy. J Neuroimmunol. 1989 Dec;25(2-3):143–150. [PubMed]
  • Latov N, Hays AP, Donofrio PD, Liao J, Ito H, McGinnis S, Konstadoulakis M, Freddo L, Shy ME, Manoussos K, et al. Monoclonal IgM with unique specificity to gangliosides GM1 and GD1b and to lacto-N-tetraose associated with human motor neuron disease. Neurology. 1988 May;38(5):763–768. [PubMed]
  • Pestronk A, Cornblath DR, Ilyas AA, Baba H, Quarles RH, Griffin JW, Alderson K, Adams RN. A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside. Ann Neurol. 1988 Jul;24(1):73–78. [PubMed]
  • Pestronk A, Adams RN, Clawson L, Cornblath D, Kuncl RW, Griffin D, Drachman DB. Serum antibodies to GM1 ganglioside in amyotrophic lateral sclerosis. Neurology. 1988 Sep;38(9):1457–1461. [PubMed]
  • Marcus DM, Latov N, Hsi BP, Gillard BK. Measurement and significance of antibodies against GM1 ganglioside. Report of a workshop, 18 April 1989, Chicago, IL, U.S.A. J Neuroimmunol. 1989 Dec;25(2-3):255–259. [PubMed]
  • Ilyas AA, Willison HJ, Quarles RH, Jungalwala FB, Cornblath DR, Trapp BD, Griffin DE, Griffin JW, McKhann GM. Serum antibodies to gangliosides in Guillain-Barré syndrome. Ann Neurol. 1988 May;23(5):440–447. [PubMed]
  • Koski CL, Chou DK, Jungalwala FB. Anti-peripheral nerve myelin antibodies in Guillain-Barre syndrome bind a neutral glycolipid of peripheral myelin and cross-react with Forssman antigen. J Clin Invest. 1989 Jul;84(1):280–287. [PMC free article] [PubMed]
  • Ilyas AA, Mithen FA, Chen ZW, Cook SD. Search for antibodies to neutral glycolipids in sera of patients with Guillain-Barré syndrome. J Neurol Sci. 1991 Mar;102(1):67–75. [PubMed]
  • Compston A, Scolding N, Wren D, Noble M. The pathogenesis of demyelinating disease: insights from cell biology. Trends Neurosci. 1991 May;14(5):175–182. [PubMed]
  • Scolding NJ, Morgan BP, Houston WA, Linington C, Campbell AK, Compston DA. Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement. Nature. 1989 Jun 22;339(6226):620–622. [PubMed]
  • Scolding NJ, Compston DA. Oligodendrocyte-macrophage interactions in vitro triggered by specific antibodies. Immunology. 1991 Jan;72(1):127–132. [PubMed]
  • Gay D, Esiri M. Blood-brain barrier damage in acute multiple sclerosis plaques. An immunocytological study. Brain. 1991 Feb;114(Pt 1B):557–572. [PubMed]
  • Sobue G, Yamoto S, Hirayama M, Matsuoka Y, Uematsu H, Sobue I. The role of macrophages in demyelination in experimental allergic neuritis. J Neurol Sci. 1982 Oct;56(1):75–87. [PubMed]
  • Trotter J, Smith ME. The role of phospholipases from inflammatory macrophages in demyelination. Neurochem Res. 1986 Mar;11(3):349–361. [PubMed]
  • Hartung HP, Schäfer B, Heininger K, Toyka KV. Suppression of experimental autoimmune neuritis by the oxygen radical scavengers superoxide dismutase and catalase. Ann Neurol. 1988 May;23(5):453–460. [PubMed]
  • Hartung HP, Schäfer B, Heininger K, Stoll G, Toyka KV. The role of macrophages and eicosanoids in the pathogenesis of experimental allergic neuritis. Serial clinical, electrophysiological, biochemical and morphological observations. Brain. 1988 Oct;111(Pt 5):1039–1059. [PubMed]
  • Stoll G, Schmidt B, Jander S, Toyka KV, Hartung HP. Presence of the terminal complement complex (C5b-9) precedes myelin degradation in immune-mediated demyelination of the rat peripheral nervous system. Ann Neurol. 1991 Aug;30(2):147–155. [PubMed]
  • Hartung HP, Schäfer B, van der Meide PH, Fierz W, Heininger K, Toyka KV. The role of interferon-gamma in the pathogenesis of experimental autoimmune disease of the peripheral nervous system. Ann Neurol. 1990 Mar;27(3):247–257. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press