Search tips
Search criteria 


Logo of jrsocmedLink to Publisher's site
J R Soc Med. 1992 January; 85(1): 12–15.
PMCID: PMC1293453

Drug treatments for mastalgia: 17 years experience in the Cardiff Mastalgia Clinic.


Mastalgia commonly presents to medical practitioners. The majority of patients can be managed by exclusion of cancer and reassurance. In some the severity of pain affects the quality of life and drug treatment should be considered. Since its inception 324 patients with cyclical mastalgia and 90 with non-cyclical mastalgia have received a therapeutic trial of drug treatment in the Cardiff Mastalgia Clinic. Overall 92% of those with cyclical mastalgia and 64% with non-cyclical mastalgia obtained a clinically useful response to therapy. Danazol was the most effective drug, with bromocriptine and evening primrose oil having equivalent efficacy. Many fewer adverse events were complained of by patients treated with evening primrose oil than danazol or bromocriptine.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (653K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Maddox PR, Mansel RE. Management of breast pain and nodularity. World J Surg. 1989 Nov-Dec;13(6):699–705. [PubMed]
  • Pye JK, Mansel RE, Hughes LE. Clinical experience of drug treatments for mastalgia. Lancet. 1985 Aug 17;2(8451):373–377. [PubMed]
  • Preece PE, Mansel RE, Bolton PM, Hughes LM, Baum M, Gravelle IH. Clinical syndromes of mastalgia. Lancet. 1976 Sep 25;2(7987):670–673. [PubMed]
  • Maddox PR, Harrison BJ, Mansel RE, Hughes LE. Non-cyclical mastalgia: an improved classification and treatment. Br J Surg. 1989 Sep;76(9):901–904. [PubMed]
  • Harrison BJ, Maddox PR, Mansel RE. Maintenance therapy of cyclical mastalgia using low-dose danazol. J R Coll Surg Edinb. 1989 Apr;34(2):79–81. [PubMed]
  • Gateley CA, Maddox PR, Mansel RE, Hughes LE. Mastalgia refractory to drug treatment. Br J Surg. 1990 Oct;77(10):1110–1112. [PubMed]
  • Fentiman IS, Caleffi M, Hamed H, Chaudary MA. Studies of tamoxifen in women with mastalgia. Br J Clin Pract Suppl. 1989 Nov;68:34–53. [PubMed]
  • Hamed H, Caleffi M, Chaudary MA, Fentiman IS. LHRH analogue for treatment of recurrent and refractory mastalgia. Ann R Coll Surg Engl. 1990 Jul;72(4):221–224. [PMC free article] [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press