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J R Soc Med. 1991 May; 84(5): 261–263.
PMCID: PMC1293220

Vasomotion in venous disease.

Abstract

Abnormalities of the capillary microcirculation may be important in the pathogenesis of venous ulceration. In this study the characteristics of capillary vasomotion in venous disease have been studied using laser Doppler flowmetry. The amplitude and frequency of vasomotion in the skin microcirculation as measured by laser Doppler flowmetry was determined in 101 subjects. These comprised 43 subjects with venous disease and lipodermatosclerosis (LDS), 14 subjects with uncomplicated varicose veins (VV), and 44 normal controls. In 43 of these 101 limbs, vasomotion was also measured after heating the skin to 43 degrees C. The resting laser Doppler flux was significantly higher in the LDS group compared to the other two groups (LDS median = 76, VV median = 47 (P less than 0.04), controls median = 49 (P less than 0.003]. The amplitude of vasomotive waves was significantly higher in the LDS group compared to controls (LDS median = 20, VV median = 8.3 (P less than 0.007), controls median = 14 (P less than 0.007), as was the frequency of vasomotion (LDS median = 3.3 waves/min, VV median = 2.5 (P = ns), controls median = 2.7 (P less than 0.007]. On heating the skin to 43 degrees C the frequency of the vasomotion increased significantly in the control (P less than 0.004) and VV (P less than 0.04) groups but not in the LDS group. The amplitude of the vaso-motion also increased significantly in the control (P less than 0.01) and VV (P less than 0.002) groups but not in the LDS group.(ABSTRACT TRUNCATED AT 250 WORDS)

Full text

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Browse NL, Burnand KG. The cause of venous ulceration. Lancet. 1982 Jul 31;2(8292):243–245. [PubMed]
  • Kastrup J, Nørgaard T, Parving HH, Lassen NA. Increased minimal vascular resistance and arteriolar hyalinosis in skin on the leg in insulin-dependent diabetic patients. Scand J Clin Lab Invest. 1987 Sep;47(5):475–482. [PubMed]
  • Coleridge Smith PD, Thomas P, Scurr JH, Dormandy JA. Causes of venous ulceration: a new hypothesis. Br Med J (Clin Res Ed) 1988 Jun 18;296(6638):1726–1727. [PMC free article] [PubMed]
  • Rayman G, Williams SA, Spencer PD, Smaje LH, Wise PH, Tooke JE. Impaired microvascular hyperaemic response to minor skin trauma in type I diabetes. Br Med J (Clin Res Ed) 1986 May 17;292(6531):1295–1298. [PMC free article] [PubMed]
  • Slaaf DW, Tangelder GJ, Teirlinck HC, Reneman RS. Arteriolar vasomotion and arterial pressure reduction in rabbit tenuissimus muscle. Microvasc Res. 1987 Jan;33(1):71–80. [PubMed]
  • Johnson PC, Wayland H. Regulation of blood flow in single capillaries. Am J Physiol. 1967 Jun;212(6):1405–1415. [PubMed]
  • Damber JE, Lindahl O, Selstam G, Tenland T. Rhythmical oscillations in rat testicular microcirculation as recorded by laser Doppler flowmetry. Acta Physiol Scand. 1983 Jun;118(2):117–123. [PubMed]
  • Christensen NJ. Spontaneous variations in resting blood flow, postischaemic peak flow and vibratory perception in the feet of diabetics. Diabetologia. 1969 Jun;5(3):171–178. [PubMed]
  • Salerud EG, Tenland T, Nilsson GE, Oberg PA. Rhythmical variations in human skin blood flow. Int J Microcirc Clin Exp. 1983;2(2):91–102. [PubMed]
  • Moyses C, Cederholm-Williams SA, Michel CC. Haemoconcentration and accumulation of white cells in the feet during venous stasis. Int J Microcirc Clin Exp. 1987;5(4):311–320. [PubMed]
  • Myers RR, Murakami H, Powell HC. Reduced nerve blood flow in edematous neuropathies: a biomechanical mechanism. Microvasc Res. 1986 Sep;32(2):145–151. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press