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J R Soc Med. 1991 March; 84(3): 140–143.
PMCID: PMC1293132

Non-secretory adenomas of the pituitary treated by trans-ethmoidal sellotomy.


A consecutive series of 35 clinically non-secretory pituitary adenomas treated surgically by the transethmodial approach is presented. Mean age at presentation was 60 years, with a male-to-female ratio of 2:1. These tumours present later than hormone secreting tumours: 90% were over 2 cm in diameter at operation. Seventy-one per cent of patients had impaired vision and 89% had hypopituitarism. Surgical treatment relieved or significantly improved visual fields in 79% of patients with impaired vision. Ninety-one per cent required permanent hormone replacement. Mean follow-up was for 4.4 years. Five tumours recurred, causing recurrent visual symptoms. No tumours recurred in those patients treated with postoperative radiotherapy, but follow-up in this group was only for a mean of 2.7 years.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Klibanski A. Nonsecreting pituitary tumors. Endocrinol Metab Clin North Am. 1987 Sep;16(3):793–804. [PubMed]
  • Scanlon MF, Peters JR, Thomas JP, Richards SH, Morton WH, Howell S, Williams ED, Hourihan M, Hall R. Management of selected patients with hyperprolactinaemia by partial hypophysectomy. Br Med J (Clin Res Ed) 1985 Nov 30;291(6508):1547–1550. [PMC free article] [PubMed]
  • Ebersold MJ, Quast LM, Laws ER, Jr, Scheithauer B, Randall RV. Long-term results in transsphenoidal removal of nonfunctioning pituitary adenomas. J Neurosurg. 1986 May;64(5):713–719. [PubMed]
  • Bevan JS, Adams CB, Burke CW, Morton KE, Molyneux AJ, Moore RA, Esiri MM. Factors in the outcome of transsphenoidal surgery for prolactinoma and non-functioning pituitary tumour, including pre-operative bromocriptine therapy. Clin Endocrinol (Oxf) 1987 May;26(5):541–556. [PubMed]
  • Arafah BM. Reversible hypopituitarism in patients with large nonfunctioning pituitary adenomas. J Clin Endocrinol Metab. 1986 Jun;62(6):1173–1179. [PubMed]

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