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J R Soc Med. 1990 November; 83(11): 724–730.
PMCID: PMC1292923

Epidemiology of mouth cancer in 1989: a review.


The oral cavity and pharynx combined is the sixth commonest site of cancer in both sexes. In many countries the mortality rate is increasing among younger men born since approximately 1910-1920. A causal role in the aetiology of mouth cancer has been established for tobacco use, both smoking and chewing, separately and in conjunction with betel-quid chewing; with alcohol consumption and, less certainly, with other factors such as poor oral hygiene, nutritional factors and certain occupational exposures. In Western countries, there is convincing evidence that a large attributable risk can be ascribed to the joint habits of cigarette smoking and alcohol consumption. In Asian societies, a high attributable risk can be ascribed to cigarette smoking and betel chewing. Mouth cancer is at the same time an important form of cancer, and one for which practical prospects for prevention already exist. Against this background of a continually increasing trend among younger persons, it seems essential to engage upon programmes of prevention, including increasing awareness for early detection, against mouth cancer at the present time.

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Selected References

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  • Parkin DM, Lärä E, Muir CS. Estimates of the worldwide frequency of sixteen major cancers in 1980. Int J Cancer. 1988 Feb 15;41(2):184–197. [PubMed]
  • Easson EC, Palmer MK. Prognostic factors in oral cancer. Clin Oncol. 1976 Sep;2(3):191–202. [PubMed]
  • WYNDER EL, BROSS IJ, FELDMAN RM. A study of the etiological factors in cancer of the mouth. Cancer. 1957 Nov-Dec;10(6):1300–1323. [PubMed]
  • Tan KN. Oral cancer in Australia. Aust Dent J. 1969 Feb;14(1):50–56. [PubMed]
  • Svejda J, Kosut V. Epidemiology of malignant tumours with special regards to the orofacial region. Neoplasma. 1971;18(2):193–196. [PubMed]
  • Szpak CA, Stone MJ, Frenkel EP. Some observations concerning the demographic and geographic incidence of carcinoma of the lip and buccal cavity. Cancer. 1977 Jul;40(1):343–348. [PubMed]
  • Hakulinen T, Andersen A, Malker B, Pukkala E, Schou G, Tulinius H. Trends in cancer incidence in the Nordic countries. A collaborative study of the five Nordic Cancer Registries. Acta Pathol Microbiol Immunol Scand Suppl. 1986;288:1–151. [PubMed]
  • Krolls SO, Hoffman S. Squamous cell carcinoma of the oral soft tissues: a statistical analysis of 14,253 cases by age, sex, and race of patients. J Am Dent Assoc. 1976 Mar;92(3):571–574. [PubMed]
  • MILLS CA, PORTER MM. Tobacco smoking habits and cancer of the mouth and respiratory system. Cancer Res. 1950 Sep;10(9):539–542. [PubMed]
  • VOGLER WR, LLOYD JW, MILMORE BK. A retrospective study of etiological factors in cancer of the mouth, pharynx, and larynx. Cancer. 1962 Mar-Apr;15:246–258. [PubMed]
  • Keller AZ, Terris M. The association of alcohol and tobacco with cancer of the mouth and pharynx. Am J Public Health Nations Health. 1965 Oct;55(10):1578–1585. [PubMed]
  • Rothman K, Keller A. The effect of joint exposure to alcohol and tobacco on risk of cancer of the mouth and pharynx. J Chronic Dis. 1972 Dec;25(12):711–716. [PubMed]
  • Graham S, Dayal H, Rohrer T, Swanson M, Sultz H, Shedd D, Fischman S. Dentition, diet, tobacco, and alcohol in the epidemiology of oral cancer. J Natl Cancer Inst. 1977 Dec;59(6):1611–1618. [PubMed]
  • Brugere J, Guenel P, Leclerc A, Rodriguez J. Differential effects of tobacco and alcohol in cancer of the larynx, pharynx, and mouth. Cancer. 1986 Jan 15;57(2):391–395. [PubMed]
  • Jussawalla DJ, Deshpande VA. Evaluation of cancer risk in tobacco chewers and smokers: an epidemiologic assessment. Cancer. 1971 Jul;28(1):244–252. [PubMed]
  • Burton-Bradley BG. Is "betel chewing" carcinogenic? Lancet. 1979 Oct 27;2(8148):903–903. [PubMed]
  • SHANTA V, KRISHNAMURTHI S. A study of aetiological factors in oral squamous cell carcinoma. Br J Cancer. 1959 Sep;13:381–388. [PMC free article] [PubMed]
  • Schmidt W, Popham RE. The role of drinking and smoking in mortality from cancer and other causes in male alcoholics. Cancer. 1981 Mar 1;47(5):1031–1041. [PubMed]
  • Monson RR, Lyon JL. Proportional mortality among alcoholics. Cancer. 1975 Sep;36(3):1077–1079. [PubMed]
  • Robinette CD, Hrubec Z, Fraumeni JF., Jr Chronic alcoholism and subsequent mortality in World War II veterans. Am J Epidemiol. 1979 Jun;109(6):687–700. [PubMed]
  • Klatsky AL, Friedman GD, Siegelaub AB. Alcohol and mortality. A ten-year Kaiser-Permanente experience. Ann Intern Med. 1981 Aug;95(2):139–145. [PubMed]
  • Kono S, Ikeda M, Tokudome S, Nishizumi M, Kuratsune M. Alcohol and mortality: a cohort study of male Japanese physicians. Int J Epidemiol. 1986 Dec;15(4):527–532. [PubMed]
  • Phillips RL, Garfinkel L, Kuzma JW, Beeson WL, Lotz T, Brin B. Mortality among California Seventh-Day Adventists for selected cancer sites. J Natl Cancer Inst. 1980 Nov;65(5):1097–1107. [PubMed]
  • WYNDER EL, FRYER JH. Etiologic considerations of Plummer-Vinson (Patterson-Kelly) syndrome. Ann Intern Med. 1958 Nov;49(5):1106–1128. [PubMed]
  • Larsson LG, Sandström A, Westling P. Relationship of Plummer-Vinson disease to cancer of the upper alimentary tract in Sweden. Cancer Res. 1975 Nov;35(11 Pt 2):3308–3316. [PubMed]
  • Marshall J, Graham S, Mettlin C, Shedd D, Swanson M. Diet in the epidemiology of oral cancer. Nutr Cancer. 1982;3(3):145–149. [PubMed]
  • Winn DM, Ziegler RG, Pickle LW, Gridley G, Blot WJ, Hoover RN. Diet in the etiology of oral and pharyngeal cancer among women from the southern United States. Cancer Res. 1984 Mar;44(3):1216–1222. [PubMed]
  • McLaughlin JK, Gridley G, Block G, Winn DM, Preston-Martin S, Schoenberg JB, Greenberg RS, Stemhagen A, Austin DF, Ershow AG, et al. Dietary factors in oral and pharyngeal cancer. J Natl Cancer Inst. 1988 Oct 5;80(15):1237–1243. [PubMed]
  • Winn DM, Blot WJ, Shy CM, Pickle LW, Toledo A, Fraumeni JF., Jr Snuff dipping and oral cancer among women in the southern United States. N Engl J Med. 1981 Mar 26;304(13):745–749. [PubMed]
  • Dean G, MacLennan R, McLoughlin H, Shelley E. Causes of death of blue-collar workers at a Dublin brewery, 1954--73. Br J Cancer. 1979 Oct;40(4):581–589. [PMC free article] [PubMed]
  • Moss E, Lee WR. Occurrence of oral and pharyngeal cancers in textile workers. Br J Ind Med. 1974 Jul;31(3):224–232. [PMC free article] [PubMed]
  • Lloyd JW, Decoufle P, Salvin LG. Unusual mortality experience of printing pressmen. J Occup Med. 1977 Aug;19(8):543–550. [PubMed]
  • Greene MH, Hoover RN, Eck RL, Fraumeni JF., Jr Cancer mortality among printing plant workers. Environ Res. 1979 Oct;20(1):66–73. [PubMed]
  • Weaver A, Fleming SM, Smith DB. Mouthwash and oral cancer: carcinogen or coincidence? J Oral Surg. 1979 Apr;37(4):250–253. [PubMed]
  • Blot WJ, Winn DM, Fraumeni JF., Jr Oral cancer and mouthwash. J Natl Cancer Inst. 1983 Feb;70(2):251–253. [PubMed]
  • Wynder EL, Stellman SD. Comparative epidemiology of tobacco-related cancers. Cancer Res. 1977 Dec;37(12):4608–4622. [PubMed]
  • Boyle P, Zheng T, Macfarlane GJ, McGinn R, Maisonneuve P, LaVecchia C, Scully C. Recent advances in the etiology and epidemiology of head and neck cancer. Curr Opin Oncol. 1990 Jun;2(3):539–545. [PubMed]

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