PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jrsocmedLink to Publisher's site
 
J R Soc Med. 1990 November; 83(11): 693–695.
PMCID: PMC1292914

Survival in acute non-lymphocytic leukaemia following breast cancer.

Abstract

Acute non-lymphocytic leukaemia (ANLL) occurs with increased frequency in women with previously diagnosed breast cancer. Adjuvant radiotherapy and chemotherapy are related to this increase. We studied the interrelationships among age at breast cancer diagnosis, interval to ANLL diagnosis, and survival in 54 women of whom 11 were from Kansas and 43 were from two other published series. Median age at breast cancer diagnosis was 50.5 years, median interval to ANLL diagnosis was 4.8 years, and median survival after ANLL diagnosis was 2.2 months. Increasing age was associated with a decrease of the interval to ANLL diagnosis just short of statistical significance (P = 0.0591). There was no association of survival with either age or the interval to ANLL diagnosis. With an increase in the use of adjuvant therapy in breast cancer there is a need to identify women at greatest risk of subsequently developing ANLL, at present not possible.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (558K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Carey RW, Holland JF, Sheehe PR, Graham S. Association of cancer of the breast and acute myelocytic leukemia. Cancer. 1967 Jul;20(7):1080–1088. [PubMed]
  • Haas JF, Kittelmann B, Mehnert WH, Staneczek W, Möhner M, Kaldor JM, Day NE. Risk of leukaemia in ovarian tumour and breast cancer patients following treatment by cyclophosphamide. Br J Cancer. 1987 Feb;55(2):213–218. [PMC free article] [PubMed]
  • Fisher B, Rockette H, Fisher ER, Wickerham DL, Redmond C, Brown A. Leukemia in breast cancer patients following adjuvant chemotherapy or postoperative radiation: the NSABP experience. J Clin Oncol. 1985 Dec;3(12):1640–1658. [PubMed]
  • Rosner F, Carey RW, Zarrabi MH. Breast cancer and acute leukemia: report of 24 cases and review of the literature. Am J Hematol. 1978;4(2):151–172. [PubMed]
  • Mehnert WH, Haas JF, Kittelmann B, Staneczek W, Möhner M, Kaldor JM, Day NE. A case-control study of leukaemia as a second primary malignancy following ovarian and breast neoplasms. IARC Sci Publ. 1986;(78):203–221. [PubMed]
  • Herring MK, Buzdar AU, Smith TL, Hortobagyi GN, Blumenschein GR. Second neoplasms after adjuvant chemotherapy for operable breast cancer. Am J Clin Oncol. 1986 Jun;9(3):269–275. [PubMed]
  • Ershler WB, Robins HI, Davis HL, Hafez GR, Meisner LF, Dahlberg S, Arndt C. Emergence of acute non-lymphocytic leukemia in breast cancer patients. Am J Med Sci. 1982 Sep-Oct;284(2):23–31. [PubMed]
  • Coleman CN, Williams CJ, Flint A, Glatstein EJ, Rosenberg SA, Kaplan HS. Hematologic neoplasia in patients treated for Hodgkin's disease. N Engl J Med. 1977 Dec 8;297(23):1249–1252. [PubMed]
  • Cadman EC, Capizzi RL, Bertino JR. Acute nonlymphocytic leukemia: a delayed complication of Hodgkin's disease therapy: analysis of 109 cases. Cancer. 1977 Sep;40(3):1280–1296. [PubMed]
  • Foucar K, McKenna RW, Bloomfield CD, Bowers TK, Brunning RD. Therapy-related leukemia: a panmyelosis. Cancer. 1979 Apr;43(4):1285–1296. [PubMed]
  • Gale RP. Advances in the treatment of acute myelogenous leukemia. N Engl J Med. 1979 May 24;300(21):1189–1199. [PubMed]
  • Kingsley EC, Durie BG. Prolonged survival in patients with treatment-related leukemia. Scand J Haematol. 1986 Aug;37(2):103–105. [PubMed]
  • Brenner B, Carter A, Sharon R, Tatarsky I. Acute leukemia following chemotherapy and radiation therapy--a report of 15 cases. Oncology. 1984;41(2):83–87. [PubMed]
  • Lerner HJ. Acute myelogenous leukemia in patients receiving chlorambucil as long-term adjuvant chemotherapy for stage II breast cancer. Cancer Treat Rep. 1978 Aug;62(8):1135–1138. [PubMed]
  • Portugal MA, Falkson HC, Stevens K, Falkson G. Acute leukemia as a complication of long-term treatment of advanced breast cancer. Cancer Treat Rep. 1979 Feb;63(2):177–181. [PubMed]
  • Mansour EG, Gray R, Shatila AH, Osborne CK, Tormey DC, Gilchrist KW, Cooper MR, Falkson G. Efficacy of adjuvant chemotherapy in high-risk node-negative breast cancer. An intergroup study. N Engl J Med. 1989 Feb 23;320(8):485–490. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press