Search tips
Search criteria 


Logo of jrsocmedLink to Publisher's site
J R Soc Med. 1990 September; 83(9): 554–556.
PMCID: PMC1292812

Comparison of a dimethicone/antacid (Asilone gel) with an alginate/antacid (Gaviscon liquid) in the management of reflux oesophagitis.


Fifty-three patients with symptomatic reflux oesophagitis were entered into a single centre randomized study comparing the effects of a dimethicone/antacid (Asilone Gel) and an alginate/antacid (Gaviscon liquid) on symptoms and endoscopic changes over an 8-week period. Both treatments significantly improved heartburn, acid regurgitation and flatulence. Dimethicone/antacid but not alginate/antacid, produced a significant improvement in oesophagitis, oesophageal ulceration and histological grade of inflammation over the 8-week treatment period so that 14 patients treated with dimethicone/antacid and 10 with alginate/antacid had normal endoscopic oesophageal appearances at the end of the study. The difference in improvement between the two patient groups did not reach significance however, except for dimethicone/antacid improving histological changes (P less than 0.05). These findings suggest that dimethicone/antacid and alginate/antacid are equally effective in treating symptomatic reflux oesophagitis although dimethicone/antacid may have an advantage in improving oesophageal histological appearances.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (548K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Castell DO. Medical therapy for reflux esophagitis: 1986 and beyond. Ann Intern Med. 1986 Jan;104(1):112–114. [PubMed]
  • Stanciu C, Bennett JR. Alginate-antacid in the reduction of gastro-oesophageal reflux. Lancet. 1974 Jan 26;1(7848):109–111. [PubMed]
  • McHardy G. A multicentric, randomized clinical trial of Gaviscon in reflux esophagitis. South Med J. 1978 Jan;71 (Suppl 1):16–21. [PubMed]
  • Ogilvie AL, Atkinson M. Does dimethicone increase the efficacy of antacids in the treatment of reflux oesophagitis? J R Soc Med. 1986 Oct;79(10):584–587. [PMC free article] [PubMed]
  • Rokkas T, Sladen GE. Ambulatory esophageal pH recording in gastroesophageal reflux: relevance to the development of esophagitis. Am J Gastroenterol. 1988 Jun;83(6):629–632. [PubMed]
  • Birtley RD, Burton JS, Kellett DN, Oswald BJ, Pennington JC. The effect of free silica on the mucosal protective and antiflatulent properties of polydimethylsiloxane. J Pharm Pharmacol. 1973 Nov;25(11):859–863. [PubMed]
  • Klinkenberg-Knol EC, Jansen JM, Festen HP, Meuwissen SG, Lamers CB. Double-blind multicentre comparison of omeprazole and ranitidine in the treatment of reflux oesophagitis. Lancet. 1987 Feb 14;1(8529):349–351. [PubMed]
  • Johnson LF, DeMeester TR. Evaluation of elevation of the head of the bed, bethanechol, and antacid form tablets on gastroesophageal reflux. Dig Dis Sci. 1981 Aug;26(8):673–680. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press