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J R Soc Med. 1990 August; 83(8): 495–496.
PMCID: PMC1292774

Anorexia nervosa associated with acromegaloid features, onset of acrocyanosis and Raynaud's phenomenon and worsening of chilblains.


Patients with anorexia nervosa may develop many physical and endocrinological complications. We wish to report two patients who developed soft tissue swelling of their hands and worsening of their peripheral vascular disease, evidenced by the appearance of acrocyanosis and Raynaud's phenomenon and more severe perniosis, following the onset of their anorexia nervosa.

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Selected References

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  • Newman MM, Halmi KA. The endocrinology of anorexia nervosa and bulimia nervosa. Endocrinol Metab Clin North Am. 1988 Mar;17(1):195–212. [PubMed]
  • Hall K, Lundin G, Póvoa G. Serum levels of the low molecular weight form of insulin-like growth factor binding protein in healthy subjects and patients with growth hormone deficiency, acromegaly and anorexia nervosa. Acta Endocrinol (Copenh) 1988 Jul;118(3):321–326. [PubMed]
  • Ashcraft MW, Hartzband PI, Van Herle AJ, Bersch N, Golde DW. A unique growth factor in patients with acromegaloidism. J Clin Endocrinol Metab. 1983 Aug;57(2):272–276. [PubMed]
  • Geffner ME, Lippe BM, Bersch N, Van Herle A, Kaplan SA, Elders MJ, Golde DW. Growth without growth hormone: evidence for a potent circulating human growth factor. Lancet. 1986 Feb 15;1(8477):343–347. [PubMed]
  • Luck P, Wakeling A. Increased cutaneous vasoreactivity to cold in anorexia nervosa. Clin Sci (Lond) 1981 Nov;61(5):559–567. [PubMed]

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