PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of jrsocmedLink to Publisher's site
 
J R Soc Med. 1990 May; 83(5): 308–311.
PMCID: PMC1292650

Lymphoproliferative responses in recrudescent orofacial herpetic infections.

Abstract

The relationship between antibody (Ab) and lympho-proliferative responses to herpes simplex virus (HSV) and recrudescent orofacial HSV lesions were investigated in 65 patients. All had HSV-specific Ab and cell mediated immune responses (CMIR) demonstrated by ELISA and in vitro lymphoproliferation respectively. Thirteen control subjects were negative in both tests. Thirty-three patients were repeatedly investigated for 6-38 months during which time they suffered 1-8 recrudescences. HSV-induced lymphoproliferation was depressed during recrudescences, rose to a peak several weeks later, and declined slowly to a background level. However, ELISA titres and lymphoproliferative responses to Concanavalin A (Con A) were high throughout and circulating peripheral blood mononuclear cell (PBMC) subsets did not change. Depressed lymphoproliferative responses to HSV antigen (Ag) during recrudescences were enhanced by removal of CD8+ cells from PBMC using either a panning technique or cell sorting; reconstitution of CD8+ cells suppressed the HSV-specific lymphoproliferative response. CD8+ cell depletion affected neither HSV-induced lymphoproliferation recrudescence, nor lymphoproliferative responses to another Ag (PPD) during recrudescence. Depressed HSV-induced lymphoproliferation during recrudescences might thus be due to CD8+ suppressor T cell (Ts) function rather than low numbers of circulating lymphocytes. Suppression or delay of normal CMIR to asymptomatic recurrent epidermal HSV infection by Ts might allow development of recrudescent HSV lesions.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (875K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Wildy P, Gell PG. The host response to herpes simplex virus. Br Med Bull. 1985 Jan;41(1):86–91. [PubMed]
  • Corey L, Spear PG. Infections with herpes simplex viruses (1). N Engl J Med. 1986 Mar 13;314(11):686–691. [PubMed]
  • El Araby II, Chernesky MA, Rawls WE, Dent PB. Depressed herpes simplex virus-induced lymphocyte blastogenesis in individuals with severe recurrent herpes infections. Clin Immunol Immunopathol. 1978 Feb;9(2):253–263. [PubMed]
  • Corey L, Reeves WC, Holmes KK. Cellular immune response in genital herpes simplex virus infection. N Engl J Med. 1978 Nov 2;299(18):986–991. [PubMed]
  • Kalimo KO, Joronen IA, Havu VK. Cell-mediated immunity against herpes simplex virus envelope, capsid, excreted, and crude antigens. Infect Immun. 1983 Jan;39(1):24–28. [PMC free article] [PubMed]
  • Cauda R, Laghi V, Tumbarello M, Ortona L, Whitley RJ. Immunological alterations associated with recurrent herpes simplex genitalis. Clin Immunol Immunopathol. 1989 May;51(2):294–302. [PubMed]
  • Tsutsumi H, Bernstein JM, Riepenhoff-Talty M, Cohen E, Orsini F, Ogra PL. Immune responses to herpes simplex virus in patients with recurrent herpes labialis: I. Development of cell-mediated cytotoxic responses. Clin Exp Immunol. 1986 Dec;66(3):507–515. [PubMed]
  • Sheridan JF, Donnenberg AD, Aurelian L, Elpern DJ. Immunity to herpes simplex virus type 2. IV. Impaired lymphokine production during recrudescence correlates with an imbalance in T lymphocyte subsets. J Immunol. 1982 Jul;129(1):326–331. [PubMed]
  • Sheridan JF, Beck M, Aurelian L, Radowsky M. Immunity to herpes simplex virus: virus reactivation modulates lymphokine activity. J Infect Dis. 1985 Sep;152(3):449–456. [PubMed]
  • Sheridan JF, Beck M, Smith CC, Aurelian L. Reactivation of herpes simplex virus is associated with production of a low molecular weight factor that inhibits lymphokine activity in vitro. J Immunol. 1987 Feb 15;138(4):1234–1239. [PubMed]
  • Vestey JP, Howie SE, Norval M, Maingay JP, Neill WA. Immune responses to herpes simplex virus in patients with facial herpes simplex and those with eczema herpeticum. Br J Dermatol. 1988 Jun;118(6):775–782. [PubMed]
  • Vestey JP, Norval M, Howie S, Maingay J, Neill WA. Variation in lymphoproliferative responses during recrudescent orofacial herpes simplex virus infections. Clin Exp Immunol. 1989 Sep;77(3):384–390. [PubMed]
  • Wainberg MA, Portnoy JD, Clecner B, Hubschman S, Lagacé-Simard J, Rabinovitch N, Remer Z, Mendelson J. Viral inhibition of lymphocyte proliferative responsiveness in patients suffering from recurrent lesions caused by herpes simplex virus. J Infect Dis. 1985 Sep;152(3):441–448. [PubMed]
  • Rüdlinger R, Norval M. Herpes simplex virus infections: new concepts in an old disease. Dermatologica. 1989;178(1):1–5. [PubMed]

Articles from Journal of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press