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J R Soc Med. 1990 March; 83(3): 146–148.
PMCID: PMC1292556

Acute changes in atherogenic and thrombogenic factors with cessation of smoking.


Tobacco smoking is associated with alterations in several factors considered to be important in the atherosclerotic process. Thirty chronic smokers were studied 2 weeks before and 2 weeks after complete tobacco withdrawal. Significant reductions in fibrinogen, haematocrit, plasma viscosity and whole blood viscosity as well as a significant increase in HDL-cholesterol were observed. As these factors are important in both atherogenesis and thrombogenesis, these observations may give insight into tobacco-induced atherosclerotic disease and may be responsible for the more rapid reduction in the incidence of cardiovascular disease that is believed to occur after stopped smoking.

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Selected References

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  • Kannel WB. Hypertension and other risk factors in coronary heart disease. Am Heart J. 1987 Oct;114(4 Pt 2):918–925. [PubMed]
  • Gotto AM., Jr Interactions of the major risk factors for coronary heart disease. Am J Med. 1986 Feb 14;80(2A):48–55. [PubMed]
  • Wilhelmsson C, Vedin JA, Elmfeldt D, Tibblin G, Wilhelmsen L. Smoking and myocardial infarction. Lancet. 1975 Feb 22;1(7904):415–420. [PubMed]
  • Aberg A, Bergstrand R, Johansson S, Ulvenstam G, Vedin A, Wedel H, Wilhelmsson C, Wilhelmsen L. Cessation of smoking after myocardial infarction. Effects on mortality after 10 years. Br Heart J. 1983 May;49(5):416–422. [PMC free article] [PubMed]
  • Mulcahy R. Influence of cigarette smoking on morbidity and mortality after myocardial infarction. Br Heart J. 1983 May;49(5):410–415. [PMC free article] [PubMed]
  • Sparrow D, Dawber TR. The influence of cigarette smoking on prognosis after a first myocardial infarction. A report from the Framingham study. J Chronic Dis. 1978;31(6-7):425–432. [PubMed]
  • Salonen JT. Stopping smoking and long-term mortality after acute myocardial infarction. Br Heart J. 1980 Apr;43(4):463–469. [PMC free article] [PubMed]
  • Smith EB. Fibrinogen, fibrin and fibrin degradation products in relation to atherosclerosis. Clin Haematol. 1986 May;15(2):355–370. [PubMed]
  • Lowe GD, Forbes CD. Blood rheology and thrombosis. Clin Haematol. 1981 Jun;10(2):343–367. [PubMed]
  • Woolf N. Thrombosis and atherosclerosis. Br Med Bull. 1978 May;34(2):137–142. [PubMed]
  • Ernst E, Matrai A, Schmölzl C, Magyarosy I. Dose-effect relationship between smoking and blood rheology. Br J Haematol. 1987 Apr;65(4):485–487. [PubMed]
  • Meade TW, Imeson J, Stirling Y. Effects of changes in smoking and other characteristics on clotting factors and the risk of ischaemic heart disease. Lancet. 1987 Oct 31;2(8566):986–988. [PubMed]
  • MUSTARD JF, MURPHY EA. Effect of smoking on blood coagulation and platelet survival in man. Br Med J. 1963 Mar 30;1(5334):846–849. [PMC free article] [PubMed]
  • Billimoria JD, Pozner H, Metselaar B, Best FW, James DC. Effect of cigarette smoking on lipids, lipoproteins, blood coagulation, fibrinolysis and cellular components of human blood. Atherosclerosis. 1975 Jan-Feb;21(1):61–76. [PubMed]
  • Siess W, Lorenz R, Roth P, Weber PC. Plasma catecholamines, platelet aggregation and associated thromboxane formation after physical exercise, smoking or norepinephrine infusion. Circulation. 1982 Jul;66(1):44–48. [PubMed]
  • Smith JR, Landaw SA. Smokers' polycythemia. N Engl J Med. 1978 Jan 5;298(1):6–10. [PubMed]
  • Richmond W, Seviour PW, Teal TK, Elkeles RS. Impaired intravascular lipolysis with changes in concentrations of high density lipoprotein subclasses in young smokers. Br Med J (Clin Res Ed) 1987 Jul 25;295(6592):246–247. [PMC free article] [PubMed]
  • Topping DL, Dwyer T, Weller RA. Peripheral vascular disease in cigarette smokers and impaired hepatic metabolism of lipoprotein remnants. Lancet. 1977 Dec 24;2(8052-8053):1327–1328. [PubMed]
  • Beckett AH, Triggs EJ. Determination of nicotine and its metabolite, cotinine, in urine by gas chromatography. Nature. 1966 Sep 24;211(5056):1415–1417. [PubMed]
  • Rampling MW, Gaffney PJ. The sulphite precipitation method for fibrinogen measurement; its use on small samples in the presence of fibrinogen degradation products. Clin Chim Acta. 1976 Feb 16;67(1):43–52. [PubMed]
  • De Schepper PJ, Van Hecken A, Daenens P, Van Rossum JM. Kinetics of cotinine after oral and intravenous administration to man. Eur J Clin Pharmacol. 1987;31(5):583–588. [PubMed]
  • Zimmerman M, McGeachie J. The effect of nicotine on aortic endothelium. A quantitative ultrastructural study. Atherosclerosis. 1987 Jan;63(1):33–41. [PubMed]
  • Stone MC, Thorp JM. Plasma fibrinogen--a major coronary risk factor. J R Coll Gen Pract. 1985 Dec;35(281):565–569. [PMC free article] [PubMed]
  • Wilhelmsen L, Svärdsudd K, Korsan-Bengtsen K, Larsson B, Welin L, Tibblin G. Fibrinogen as a risk factor for stroke and myocardial infarction. N Engl J Med. 1984 Aug 23;311(8):501–505. [PubMed]
  • Meade TW, Mellows S, Brozovic M, Miller GJ, Chakrabarti RR, North WR, Haines AP, Stirling Y, Imeson JD, Thompson SG. Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet. 1986 Sep 6;2(8506):533–537. [PubMed]
  • Kannel WB, Wolf PA, Castelli WP, D'Agostino RB. Fibrinogen and risk of cardiovascular disease. The Framingham Study. JAMA. 1987 Sep 4;258(9):1183–1186. [PubMed]
  • Ritchie DG, Fuller GM. Hepatocyte-stimulating factor: a monocyte-derived acute-phase regulatory protein. Ann N Y Acad Sci. 1983 Jun 27;408:490–502. [PubMed]
  • Bennett NB, Ogston CM, McAndrew GM, Ogston D. Studies on the fibrinolytic enzyme system in obesity. J Clin Pathol. 1966 May;19(3):241–243. [PMC free article] [PubMed]
  • Ernst E, Weihmayr T, Schmid M, Baumann M, Matrai A. Cardiovascular risk factors and hemorheology. Physical fitness, stress and obesity. Atherosclerosis. 1986 Mar;59(3):263–269. [PubMed]
  • Wood PD, Stefanick ML, Dreon DM, Frey-Hewitt B, Garay SC, Williams PT, Superko HR, Fortmann SP, Albers JJ, Vranizan KM, et al. Changes in plasma lipids and lipoproteins in overweight men during weight loss through dieting as compared with exercise. N Engl J Med. 1988 Nov 3;319(18):1173–1179. [PubMed]
  • Stubbe I, Eskilsson J, Nilsson-Ehle P. High-density lipoprotein concentrations increase after stopping smoking. Br Med J (Clin Res Ed) 1982 May 22;284(6328):1511–1513. [PMC free article] [PubMed]

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